Keywords: immune system, immunomodulators, poultry, heat stress, vitamins, hematological indicators.


Our purpose was to determine the effectiveness of supplementing the rations of chickens with vitamins contained in the preparation "Incombivit", namely: vitamin A – 15,000 IU, vitamin D3 – 7,500 IU, vitamin B1 – 10 mg, vitamin E – 20 mg, vitamin B3 (nicotinamide) – 50 mg, vitamin B2 – 5 mg, vitamin B4 (choline chloride) – 12.5 mg, vitamin B5 (D-panthenol) – 25 mg, vitamin B6 – 3 mg, vitamin B7 (biotin) – 0.125 mg, vitamin B9 (folic acid) – 0.15 mg, vitamin B12 – 0.05 mg, in combination with "Aspir-35" – a preparation containing: acetylsalicylic acid – 350 mg, succinic acid – 90 mg and citric acid – 160 mg. on the productivity, quality of eggs, hematological indicators of the serum of laying hens, when they are used during the summer season, namely for the purpose of preventing heat stress. "Incombivit" is a combined drug, which, in addition to fat- and water-soluble vitamins, contains microelements and amino acids, which have the ability to normalize metabolism, affect the increase of general resistance. All three organic acids contained in the drug "Aspir-35" (salicylic, succinic and citric) take part in the regulation of redox processes, protein, carbohydrate and mineral metabolism, stimulate the liver, affect blood clotting, permeability of capillaries and the formation of steroid hormones. Being antioxidants and antihypoxanthemia, they undergo transformation in the Krebs cycle and provide cells with carbon dioxide and energy due to the accumulation of ATP and NADPH. Organic acids contained in Aspir-35 direct the thermal energy of the body to the synthesis of glycogen, ATP and NADP, which reduces overheating of the bird. Parallel cooling of the body occurs due to the expansion of skin capillaries, which is provided by acetylsalicylic acid. A total of 150 Leghorn laying hens were used for the study. The birds were divided into control and experimental groups with identical feeding conditions. The first group was the control (group I), the control group was given only the basic diet. Group (II) is an experimental group that was given "Incombivit". Group (ІІІ) is an experimental group that was given "Incombivit" in combination with "Aspir-35". The experimental drugs were drunk through the water supply system after filling the poultry house in the summer. Laboratory tests of blood serum samples were carried out. According the results we can conclude that the combined use of both experimental drugs in the hot summer period of "Incombivit" and "Aspir-35" had a good result in reducing the harmful effects of high ambient temperature on laying hens.


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