Keywords: Avizuril, poultry, eimeria, treatment, indicators of homeostasis.


Eimeriosis is one of the main problems of commercial poultry farming. Eimeriosis outbreaks cause great financial losses for poultry farms. Measures aimed at combating poultry eimeria and the cost of anti-eimeria drugs also require financial costs. Therefore, it is very important to develop modern domestic drugs for the fight against eimeria, which can compete with foreign analogues, and to which eimeria has not yet developed resistance. In their experiments, they used Avizuril, a domestic drug produced by NVF "Brovafarma", which contains only one active ingredient – toltrazuril. Two groups of 16 chickens each were used in the experiment. The experimental group was spontaneously invaded by pathogens: E. tenella and E. necatrix. In the control group there was a clinically healthy bird, in the droppings of which Eimeria oocysts were not detected. To determine the morphological and biochemical indicators of blood, it was collected from the sub-pterygoid vein in the morning before feeding on the 1st, 5th and 15th day after the course of drug administration. Studies carried out on the fifth day indicate the continuation of the therapeutic effect of the drug. Eimeria was detected in only 20% of the flock, and the intensity of infestation in sick birds decreased to 900 oocysts in one gram of droppings. When studying the indicators on the 15th day after treatment, it was established that Eimeria was detected in only one bird, which was 6.2% of the total number of experimental objects. In this case, the intensity of infestation was 200 oocysts in one gram of droppings. The use of the drug Avizuril, which has high therapeutic properties, contributed to the reduction of the extensiveness and intensity of the infestation in experimental birds during the entire period of observation during the experiment. The use of the drug Avizuril also had a positive effect on the course of the disease, namely, it contributed to the cessation of diarrhea on the third day after its use in all birds in the experimental group. Studies of the morphological indicators of the blood of the experimental bird established the restoration of the number of erythrocytes, the decrease of the number of leukocytes in the experimental group. The use of the drug Avizuril contributed to a decrease in the number of basophils by 0.8% and eosinophils by 5.2% compared to the indicators of sick birds, an increase in the level of pseudoeosinophils by 7.7% was noted, which indicates the anti-inflammatory effect of the use of the drug Avizuril. The use of Avizuril contributed to the restoration of the state of the liver and the general homeostasis of the bird's body, which was manifested by the restoration of the biochemical indicators of the blood serum of chickens to the indicators of the control group.


1. Adhikari, P., Kiess, A., Adhikari, R., & Jha, R. (2020). An approach to alternative strategies to control avian coccidiosis and necrotic enteritis. Journal of applied poultry research, 29(2), 515-534.
2. Avizuril [Avizuril]. Retrieved from: [in Ukrainian].
3. Barrios, M. A., Da Costa, M., Kimminau, E., Fuller, L., Clark, S., Pesti, G., & Beckstead, R. (2017). Relationship between broiler body weights, Eimeria maxima gross lesion scores, and microscores in three anticoccidial sensitivity tests. Avian diseases, 61(2), 237-241.
4. Blake, D. P., Clark, E. L., Macdonald, S. E., Thenmozhi, V., Kundu, K., Garg, R., ... & Tomley, F. M. (2015). Population, genetic, and antigenic diversity of the apicomplexan Eimeria tenella and their relevance to vaccine development. Proceedings of the National Academy of Sciences, 112(38), E5343-E5350.
5. Blake, D. P., Knox, J., Dehaeck, B., Huntington, B., Rathinam, T., Ravipati, V., ... & Tomley, F. M. (2020). Re-calculating the cost of coccidiosis in chickens. Veterinary Research, 51, 1-14.
6. Blake, D. P., Marugan-Hernandez, V., & Tomley, F. M. (2021). Spotlight on avian pathology: Eimeria and the disease coccidiosis. Avian Pathology, 50(3), 209-213.
7. Carvalho, F. S., Wenceslau, A. A., Teixeira, M., Carneiro, J. A. M., Melo, A. D. B., & Albuquerque, G. R. (2011). Diagnosis of Eimeria species using traditional and molecular methods in field studies. Veterinary Parasitology, 176(2-3), 95-100.
8. Chapman, H. D., Barta, J. R., Blake, D., Gruber, A., Jenkins, M., Smith, N. C., ... & Tomley, F. M. (2013). A selective review of advances in coccidiosis research. Advances in parasitology, 83, 93-171.
9. Chapman, H. D., Jeffers, T. K., & Williams, R. B. (2010). Forty years of monensin for the control of coccidiosis in poultry. Poultry science, 89(9), 1788-1801.
10. Chaudhari, A. A., Lee, Y., & Lillehoj, H. S. (2020). Beneficial effects of dietary supplementation of Bacillus strains on growth performance and gut health in chickens with mixed coccidiosis infection. Veterinary parasitology, 277, 109009.
11. Chaves Hernández A. J. (2014). Poultry and Avian Diseases. Encyclopedia of Agriculture and Food Systems, 504–520.
12. Conway, D. P., & McKenzie, M. E. (2007). Poultry coccidiosis. Diagnostic and Testing Procedures. 2nd ed., Wiley- Blackwell, Ames, IA.
13. Dakhno, I.S., Berezovskyi, A.V., Halat, V.F., Aranchii, S.V. (2001). Atlas helmintiv tvaryn [Atlas of animal helminths] K.: Vetinform, 2001. 117 s. [in Ukrainian].
14. Fatoba, A. J., & Adeleke, M. A. (2018). Diagnosis and control of chicken coccidiosis: a recent update. Journal of Parasitic Diseases, 42, 483-493.
15. Hunko, O., & Fotina, T. (2022). Vyznachennia hostroi toksychnosti protyprotozoinoho preparatu «Avizuryl» [Determination of acute toxicity of antiprotozoal drug «Avizuril»]. Naukovyi visnyk LNU veterynarnoi medytsyny ta biotekhnolohii. Seriia: Veterynarni nauky, 24(106), 136-141. [in Ukrainian].
16. Jang, S. I., Lillehoj, H. S., Lee, S. H., Lee, K. W., Lillehoj, E. P., Hong, Y. H., ... & Chun, J. E. (2013). Relative disease susceptibility and clostridial toxin antibody responses in three commercial broiler lines coinfected with Clostridium perfringens and Eimeria maxima using an experimental model of necrotic enteritis. Avian Diseases, 57(3), 684-687.
17. Jenkins, M. (2004). Control of avian coccidiosis: drugs and vaccines. London: Miscel‑laneous Publishing Information Bulletin, 3.
18. Kadykalo, S., Roberts, T., Thompson, M., Wilson, J., Lang, M., & Espeisse, O. (2018). The value of anticoccidials for sustainable global poultry production. International Journal of Antimicrobial Agents, 51(3), 304-310.
19. Karamon, J., Ziomko, I., Cencek, T., & Sroka, J. (2008). Modified flotation method with the use of Percoll for the detection of Isospora suis oocysts in suckling piglet faeces. Veterinary parasitology, 156(3-4), 324–328. https://doi. org/10.1016/j.vetpar.2008.05.020.
20. Levchenko, V.І., Sokolyuk, V.M., Bezukh, V.M. (2002). Doslіdzhennya krovі tvarin ta klіnіchna іnterpretatsіya otrimanikh rezultatіv [Examination of animal blood and clinical interpretation of the obtained results]. Bіla Tserkva. 56 s. [in Ukrainian].
21. Lillehoj, H. S., Ding, X., Quiroz, M. A., Bevensee, E., & Lillehoj, E. P. (2005). Resistance to intestinal coccidiosis following DNA immunization with the cloned 3-1E Eimeria gene plus IL-2, IL-15, and IFN-γ. Avian diseases, 49(1), 112-117.
22. Lillehoj, H., & Okamura, M. (2003). Host immunity and vaccine development to coccidia and Salmonella infections in chickens. The Journal of Poultry Science, 40(3), 151-193.
23. Park, S. S., Lillehoj, H. S., Allen, P. C., Park, D. W., FitzCoy, S., Bautista, D. A., & Lillehoj, E. P. (2008). Immunopathology and cytokine responses in broiler chickens coinfected with Eimeria maxima and Clostridium perfringens with the use of an animal model of necrotic enteritis. Avian Diseases, 52(1), 14-22.
24. Peek, H. W. (2010). Resistance to anticoccidial drugs: alternative strategies to control coccidiosis in broilers. Utrecht University.
25. Peek, H. W., & Landman, W. J. M. (2011). Coccidiosis in poultry: anticoccidial products, vaccines and other prevention strategies. Veterinary quarterly, 31(3), 143-161.
26. Pellerdy L.P. (1965). Coccidia and coccidiosis. Academia Kiado, Budapest. P. 389-396.
27. Taylor, M. A. (2016). Veterinary Parasitology. Wiley Blackwell, 128–130.
28. Williams, R. B. (1998). Epidemiological aspects of the use of live anticoccidial vaccines for chickens. International journal for parasitology, 28(7), 1089-1098.
29. Williams, R. B. (2005). Intercurrent coccidiosis and necrotic enteritis of chickens: rational, integrated disease management by maintenance of gut integrity. Avian pathology, 34(3), 159-180.
30. Witcombe, D. M., & Smith, N. C. (2014). Strategies for anti-coccidial prophylaxis. Parasitology, 141(11), 1379-1389.
How to Cite
Fotina, T. I., & HunkoО. A. (2023). ASSESSMENT OF THE THERAPEUTIC EFFECTIVENESS OF ANTIPROTOZOIC DRUG AVIZURIL. Bulletin of Sumy National Agrarian University. The Series: Veterinary Medicine, (3(62), 107-112.