@article{Shkromada_Fotina_Fotina_Nechyporenko_Petrov_Fotin_2022, title={EFFECT OF BACILLUS SUBTILIS ON PIGS ON WEANING}, url={https://snaubulletin.com.ua/index.php/vm/article/view/609}, DOI={10.32845/bsnau.vet.2022.1.8}, abstractNote={<p>Intensive rearing of pigs leads to deterioration of sanitary and hygienic conditions. In addition, industrial stress reduces the resistance of animals. Breakthrough of immunity is reflected in an increase in cases of infectious diseases among young animals. To prevent the unjustified use of antibiotics and improve the immune response in piglets, tests of probiotic strains of Bacillus subtilis were conducted in the pig farm «Institute of Agriculture of the Northeast» NAAS of Ukraine from October to November 2021. The object of research were piglets (up to 30 days) on the rearing of Landrace + Big breed. Probiotic strains of bacteria of the genera Bacillus subtilis Wogene, Bacillus subtilis Hanzhou VEGA, Bacillus subtilis Hansen and Bacillus subtilis Challenge were given to piglets at the rate of 0.3 kg per ton of water. Content of bacteria of the genus Bacillus subtilis CFU / g: 4 – 4,5 × 109 CFU in 1 g. Conditions of keeping and fattening in the control and experimental groups were the same. The adhesive properties of Bacillus subtilis were studied by the method of VI Brillis. For biochemical analysis, blood was obtained from the jugular vein. The content of total protein and its fractions was determined using an automatic biochemical analyzer using appropriate diagnostic systems. Studies have shown that the highest average daily gain was observed in the group of piglets fed B. subtilis Chellenge. The difference between the control and study groups was 2,08 %. Metabolic parameters in piglets in the group with B. subtilis Chellenge had a higher level of lysozyme by 14,7 %; γ-globulin - by 6,9 % and albumin - by 2,9 %, compared with the control group of animals. The strain of B. subtilis Challenge IAM 4,86 ± 0,24 also had the highest adhesion rates. The results of the research established the most effective strain of bacteria for use in this pig farm Bacillus subtilis Challenge, which can be used for piglets as an alternative to antibiotics. It was also found that the use of Bacillus subtilis in the diet of experimental animals improves protein metabolism in the body. The prospect of further research in this direction is to determine the mechanism of action of Bacillus subtilis probiotics on isolates of pathogenic microorganisms and to determine the therapeutic effect in pigs.</p&gt;}, number={1 (56)}, journal={Bulletin of Sumy National Agrarian University. The series: Veterinary Medicine}, author={Shkromada, O. I. and Fotina, T. I. and Fotina, H. A. and Nechyporenko, O. L. and Petrov, R. V. and Fotin, A. I.}, year={2022}, month={Jun.}, pages={51-57} }