РHYSIOLOGICAL AND BIOCHEMICAL STATUS OF THE ORGANISM UNDER THE CONDITIONS OF THE DEVELOPMENT OF NEOPLASMS

Abstract

This article presents data from the study of mammary gland neoplasms in 147 small animals. The study was conducted at the Diavet veterinary clinic in Kyiv. Neoplasms were diagnosed on the skin in 47 dogs and 24 cats, on the mammary gland in 38 cats and 17 dogs, in the oral cavity in 10 dogs and 11 cats. The results of the treatment of neoplasms of the skin, mammary glands and oral cavity in small animals show that the period after surgery is an important component of this process. Skin neoplasms were identified in 63.51% of dogs and 32.88% of cats, which is 1.93 times less. We diagnosed mammary gland neoplasms in 22.97% of dogs, and in cats this percentage was 2.27 times higher and amounted to 52.05%. The percentage of neoplasms in the oral cavity of animals of both groups the fluctuated within the limits from 13.52 to 15.07. We found the most significant percentage of neoplasms in dogs on the skin and their location is most often the wall of the abdominal cavity, lateral parts of the thoracic cavity, and the head region. The occurrence of neoplasms on the skin is influenced by the physical activity of animals. It is accompanied by frequent damage to the сommon integument body, while neoplasms continue to grow. Surgical removal of mammary gland and regional lymph node neoplasms in dogs and cats has a positive effect on the clinical blood count. In dogs and cats, the number of leukocytes stabilized on the 14th day after surgery. The number of leukocytes in the blood of dogs was lower by 2.50 times compared to preoperative values, and by 2.49 times in cats (p < 0.001). Thе content of lymphocytes in the blood of animals was significantly higher, by 1.09 (p < 0.05) – 3.35 times (p < 0.001), on day 14 of the study. The number of red blood cells on the 14th day of the study in the blood of dogs was 1.88 (p<0.01), and in cats 1.10 times less (p<0.05). In our opinion, such analysis of blood parameters on the 14th day after surgery indicates the stabilization of hemocytopoiesis in the body of animals. The content of total protein in the blood of animals on the 14th day after removal of tumors increased significantly, 1.20 times in cats and 1.08 times in dogs (p<0.05). The albumin content in the blood of animals after surgerywas 1.48 (p<0.01) to 1.16 times higher (p<0.05). The content of globulins in the blood of animals on the 14th day of the study was significantly higher. A decrease in ALT and glucose activity by 1.97-1.33 times and an increase in alkaline phosphatase activity were found, indicating the restoration of liver function, which is very important in the process of establishing homeostasis.