BABESIOSIS OF SHEEP (DISTRIBUTION, COURSE, TREATMENT)
Keywords:
babesiosis, sheep, intensity of invasion, extensiveness of invasion, antiparasitic drugs
Abstract
Livestock is the main and one of the competitive types of agribusiness, the viability and dynamism of which is due to the effective needs of the population in quality and safe food. This article presents the results and analysis of monitoring studies of the incidence of babesiosis in farms in the north-eastern part of Ukraine and the Sekiere region in the Ashant region of the Republic of Ghana (Africa). Experimental studies were performed at the Department of Epizootology and Parasitology of Sumy National Agrarian University, Center for Veterinary Medicine "Health" in Sumy. The prevalence of hemoparasites in sheep is determined. The peculiarities of the course of sheep babesiosis have been studied. The extent of the invasion and the intensity of the invasion have been estimated. The results of pathological anatomical studies of biological material have been presented and the effectiveness of the treatment measures has been scored. Babesia motasi was isolated during the blood test of sick sheep kept in Ukrainian farms. The extent of the invasion was 34,2% during the outbreak of the disease. The intensity of the invasion reached 3-5 specimens in the field of view of the microscope. The acute course of the disease was observed in 16.8% of sheep. In the study of the blood of sick sheep kept in private farms of the population of the Republic of Ghana, isolated Babesia ovis and Babesia motasi; at the outbreak of the disease, the extent of the invasion was 1.2%. The intensity of the invasion reached 1-3 specimens in the field of view of the microscope. In the comparative aspect for the treatment of animals in the farms of the north-eastern part of Ukraine used drugs LLC "Brovapharma", Ukraine; Imkar (active substance: imidocarb dipropinate 120 mg in 1 ml) and the drug Azidin-vet, the active substance of this drug is diminase acetate and phenazone. Antiprotozoal drugs were used in conjunction with symptomatic therapy. The proposed treatment regimens for sick sheep with babesiosis provided high extensefficiency (100%).
References
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5. European convention for the protection of vertebrate animals used for experimental and other scientific purposes. (1986, March).
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8. Habibi, G., Sepahvand-Mohammadi, E., Afshari, A., & Bozorgi, S. (2020). Molecular detection of Theileria spp. and Babesia ovis Infection in Sheep in Baneh, Iran. Arch Razi Inst., 75(2), 289–296. doi: 10.22092/ari.2019.125136.1297.
9. Haghi, M. M., Etemadifar, F., Fakhar, M., Teshnizi, S. H., Soosaraei, M., Shokri, A., Hajihasani, A., & Mashhadi, H. (2017). Status of babesiosis among domestic herbivores in Iran: a systematic review and meta-analysis. Parasitol Res., 116(4), 1101–1109. doi: 10.1007/s00436-016-5368-8
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12. Hasheminasab, S. S., Moradi P., & Wright I. (2018). A four year epidemiological and chemotherapy survey of babesiosis and theileriosis, and tick vectors in sheep, cattle and goats in Dehgolan, Iran. Ann Parasitol., 64(1), 43–48. doi: 10.17420/ap6401.131.
13. Hussain, M. H., Saqib, M., & Raza, F. (2014). Seroprevalence of Babesia caballi and Theileria equi in five draught equine populated metropolises of Punjab, Pakistan. Vet Parasitol., 202, 248–256.
14. European convention for the protection of vertebrate animals used for experimental and other scientific purposes. [Ievropeiska konventsiia pro zakhyst khrebetnykh tvaryn, shcho vykorystovuiutsia dlia doslidnytskykh abo inshykh naukovykh tsilei]. Verkhovna Rada Ukrainy, ofitsiinyi veb-portal: Mizhnarodni dokumenty (Rada Yevropy). Vidnovleno z http://zakon4.rada.gov.ua/laws/main?find=1&sp=i&user=c393&text=%F2%E2%E0 (in Ukrainian).
15. Jafarbekloo, A., Ramzgouyan, M. Ra., Shirian, S., Tajedin, L., Bakhshi, H., F., Sedaghat, M., & Telmadarraiy, Z. (2018). Molecular Characterization and Phylogenetic Analysis of Theileria spp. and Babesia spp. Isolated from Various Ticks in Southeastern and Northwestern Regions of Iran. Vector Borne Zoonotic Dis., 18(11), 595–600. doi: 10.1089/vbz.2018.2271.
16. Kage, S., Mamatha, G. S., Lakkundi, J.N., & D’Souza P. E. (2019). Detection of incidence of Babesia spp. in sheep and goats by parasitological diagnostic techniques. J Parasit Dis., 43(3): 452–457. doi: 10.1007/s12639-019-01109-3
17. Masatani, T., Hayashi, K., & Andoh, M. (2017). Detection and molecular characterization of Babesia, Theileria, and Hepatozoon species in hard ticks collected from Kagoshima, the southern region in Japan. Ticks Tick-borne Dis., 8, 581–587.
18. Mousa M.H., Etemadifar, F., & Mashhadi, H. (2017). Status of babesiosis among domestic herbivores in Iran: a systematic review and meta-analysis. Parasitol Res., 116(4), 1101–1109. doi: 10.1007/s00436-016-5368-8
19. Mushtaq, A., Shoukat, T., & Haroon, A. (2021). Tick-borne Diseases in Sheep and Goats in Pakistan: A Systematic Review and Meta-analysis. Acta Parasitol., 15. doi: 10.1007/s11686-021-00396-2.
20. Naderi, A., Nayebzadeh, H., & Gholami, S. (2017). Detection of Babesia infection among human, goats and sheep using microscopic and molecular methods in the city of Kuhdasht in Lorestan Province, West of Iran. Parasit Dis., 41(3), 837–842. doi: 10.1007/s12639-017-0899-1.
21. Ozubek, S., & Aktas, M. (2017).Molecular and Parasitological Survey of Ovine Piroplasmosis, Including the First Report of Theileria annulata (Apicomplexa: Theileridae) in Sheep and Goats from Turkey. J Med Entomol., 54(1), 212–220. doi: 10.1093/jme/tjw134
22. Pokhyl, S. I., Bodnia, K. I., & Torianyk I. I. Babezioz. Kolektyvna monohrafiia [Babesiosis: A collective monograph]. FOP Brovin O. V., Kharkiv, 204 (in Ukrainian). doi 10.11603/1681-2727.2020.1.11112
23. Poriadok provedennia naukovymy ustanovamy doslidiv, eksperymentiv na tvarynakh. (2012). Ofitsiinyi visnyk Ukrainy, 24, s. 82.
24. QL, Liu Z.J., & Yu P.F. (2015). Genetic characterization and molecular survey of Babesia bovis, Babesia bigemina and Babesia ovata in cattle, dairy cattle and yaks in China. Parasites & Vectors., 8, 518.
25. Rjeibi, M. R, Darghouth, M. A, & Gharbi, M. (2016). Prevalence of Theileria and Babesia species in Tunisian sheep. Onderstepoort J Vet Res., 24;83(1), a1040. doi: 10.4102/ojvr.v83i1.1040.
26. Rouatbi, M., Romdhane, R., Bouaicha, F., Sassi, L., Dhibi, M., Rekik, M., Aynalem, H., Mwacharo J. M., Rischkowsky B., Darghouth M.A., & Gharbi M. (2020). Individual variability among autochthonous sheep in Northern Tunisia to infection by abomasum nematodes and Babesia/Theileria parasites. Vet Med Sci., 6(4), 834–845. doi: 10.1002/vms3.310.
27. Sevinc, F., Turgut, K., Sevinc, M., Ekici, O.D., Coskun, A., Koc, Y., Erol, M., & Ica, A. (2007). Therapeutic and prophylactic efficacy of imidocarb dipropionate on experimental Babesia ovis infection of lambs. Vet Parasitol., 149(1–2), 65–71. doi: 10.1016/j.vetpar.2007.07.014
28. Sevinc, F., Mo, Z., Shinuo, C., Ceylan, O., Aydin, M. F., Mutlu, S., & Xuenan, X. (2018). Haemoparasitic agents associated with ovine babesiosis: A possible negative interaction between Babesia ovis and Theileria ovis. Vet Parasitol., 15(252), 143–147. doi: 10.1016/j.vetpar.2018.02.013.
29. Shayan, P., Hooshmand., E., Nabian, S., & Rahbari, S. (2008). Biometrical and genetical characterization of large Babesia ovis in Iran. Parasitol Res., 103, 217–221. doi.org/10.1007/s00436-008-0960-1
30. Sivakumar, T. Tuvshintulga Bumduuren, Silva Seekkuge S P, Ybañez Adrian P, Ybañez Rochelle H D, Benitez Daniel F, Tayebwa Dickson S, De Macedo Alan C C, Schnittger Leonhard, Yokoyama Naoaki (2020). Host range and geographical distribution of Babesia sp. Mymensingh. Transbound Emerg Dis., 13. doi: 10.1111/tbed.13546.
31. Sivakumar, T., Tuvshintulga, B., Zhyldyz, A., Kothalawala, H., Yapa, P.R., Kanagaratnam, R., Vimalakumar, S.C., Abeysekera, T.S., Weerasingha, A.S., Yamagishi, J., Igarashi, I., Silva, S.S.P. & Yokoyama, N. (2018). Genetic analysis of Babesia isolates from cattle with clinical babesiosis in Sri Lanka. J. Clin. Microbiology, 56(11), e00895–18. doi: 10.1128/JCM.00895-18.
32. Tian, Z., Liu G, Yin, H., & Tian, M. (2013). Discrimination between ovine Babesia and Theileria species in China based on the ribosomal protein S8 (RPS8) gene. Vet. Parasitol., 197 (1–2), 354–359. doi: 10.1016/j.vetpar.2013.04.033.
33. Wang, T., Guan, G., Korhonen, P. K, Koehler, A. V., Young, N. D, Hall, R. S, Yin, H., & Gasser, R. B (2017). Mitochondrial genomes of two Babesia taxa from sheep in China as a foundation for population genetic and epidemiological investigations. Infect Genet Evol., 47, 51–55. doi: 10.1016/j.meegid.2016.11.002.
2. Ali, S. S. S., Khan, M. I., & Rahman, H. U. (2017). Epidemiological and hematological investigations of tick-borne diseases in small ruminants in Peshawar and Khyber Agency, Pakistan. J Adv Parasitol., 4(1), 15.
3. Altay, K., Aktas, M., & Dumanli, N. (2008). Detection of Babesia ovis by PCR in Rhipicephalus bursa collected from naturally infested sheep and goats. Res Vet Sci., 85(1), 116–119. doi: 10.1016/j.rvsc.2007.08.002
4. Barbosaa, A., Reiss, A., & Jackson, B. (2017). Prevalence, genetic diversity and potential clinical impact of bloodborne and enteric protozoan parasites in native mammals from northern Australia. Vet Parasitol., 238, 94–105.
5. European convention for the protection of vertebrate animals used for experimental and other scientific purposes. (1986, March).
6. Friedhoff, K.T. (1997). Tick-borne diseases of sheep and goats caused by Babesia, Theileria or Anaplasma spp. Parassitologia, 39(2), 99–109.
7. Gray, A., Capewell, P., Loney, C., Katzer, F., Shiels, B. R. & Weir, W. (2019). Sheep as Host Species for Zoonotic Babesia venatorum, United Kingdom. Emerg Infect Dis., 25(12), 2257–2260. doi: 10.3201/eid2512.190459.
8. Habibi, G., Sepahvand-Mohammadi, E., Afshari, A., & Bozorgi, S. (2020). Molecular detection of Theileria spp. and Babesia ovis Infection in Sheep in Baneh, Iran. Arch Razi Inst., 75(2), 289–296. doi: 10.22092/ari.2019.125136.1297.
9. Haghi, M. M., Etemadifar, F., Fakhar, M., Teshnizi, S. H., Soosaraei, M., Shokri, A., Hajihasani, A., & Mashhadi, H. (2017). Status of babesiosis among domestic herbivores in Iran: a systematic review and meta-analysis. Parasitol Res., 116(4), 1101–1109. doi: 10.1007/s00436-016-5368-8
10. Halat, V.F., Berezovskyi, A.V., & Halat, M.V. Hlobalna parazytolohiia [Global parasitology]. Diia, Kyiv, 568 (in Ukrainian).
11. Haq, A. U., Tufani, N., Gugjoo, M. B., Nabi, S. U., & Malik, H. U. (2017). Therapeutic amelioration of severely anaemic local Kashmiri goats affected with babesiosis. Adv Anim Vet Sci., 5(11), 463–467.
12. Hasheminasab, S. S., Moradi P., & Wright I. (2018). A four year epidemiological and chemotherapy survey of babesiosis and theileriosis, and tick vectors in sheep, cattle and goats in Dehgolan, Iran. Ann Parasitol., 64(1), 43–48. doi: 10.17420/ap6401.131.
13. Hussain, M. H., Saqib, M., & Raza, F. (2014). Seroprevalence of Babesia caballi and Theileria equi in five draught equine populated metropolises of Punjab, Pakistan. Vet Parasitol., 202, 248–256.
14. European convention for the protection of vertebrate animals used for experimental and other scientific purposes. [Ievropeiska konventsiia pro zakhyst khrebetnykh tvaryn, shcho vykorystovuiutsia dlia doslidnytskykh abo inshykh naukovykh tsilei]. Verkhovna Rada Ukrainy, ofitsiinyi veb-portal: Mizhnarodni dokumenty (Rada Yevropy). Vidnovleno z http://zakon4.rada.gov.ua/laws/main?find=1&sp=i&user=c393&text=%F2%E2%E0 (in Ukrainian).
15. Jafarbekloo, A., Ramzgouyan, M. Ra., Shirian, S., Tajedin, L., Bakhshi, H., F., Sedaghat, M., & Telmadarraiy, Z. (2018). Molecular Characterization and Phylogenetic Analysis of Theileria spp. and Babesia spp. Isolated from Various Ticks in Southeastern and Northwestern Regions of Iran. Vector Borne Zoonotic Dis., 18(11), 595–600. doi: 10.1089/vbz.2018.2271.
16. Kage, S., Mamatha, G. S., Lakkundi, J.N., & D’Souza P. E. (2019). Detection of incidence of Babesia spp. in sheep and goats by parasitological diagnostic techniques. J Parasit Dis., 43(3): 452–457. doi: 10.1007/s12639-019-01109-3
17. Masatani, T., Hayashi, K., & Andoh, M. (2017). Detection and molecular characterization of Babesia, Theileria, and Hepatozoon species in hard ticks collected from Kagoshima, the southern region in Japan. Ticks Tick-borne Dis., 8, 581–587.
18. Mousa M.H., Etemadifar, F., & Mashhadi, H. (2017). Status of babesiosis among domestic herbivores in Iran: a systematic review and meta-analysis. Parasitol Res., 116(4), 1101–1109. doi: 10.1007/s00436-016-5368-8
19. Mushtaq, A., Shoukat, T., & Haroon, A. (2021). Tick-borne Diseases in Sheep and Goats in Pakistan: A Systematic Review and Meta-analysis. Acta Parasitol., 15. doi: 10.1007/s11686-021-00396-2.
20. Naderi, A., Nayebzadeh, H., & Gholami, S. (2017). Detection of Babesia infection among human, goats and sheep using microscopic and molecular methods in the city of Kuhdasht in Lorestan Province, West of Iran. Parasit Dis., 41(3), 837–842. doi: 10.1007/s12639-017-0899-1.
21. Ozubek, S., & Aktas, M. (2017).Molecular and Parasitological Survey of Ovine Piroplasmosis, Including the First Report of Theileria annulata (Apicomplexa: Theileridae) in Sheep and Goats from Turkey. J Med Entomol., 54(1), 212–220. doi: 10.1093/jme/tjw134
22. Pokhyl, S. I., Bodnia, K. I., & Torianyk I. I. Babezioz. Kolektyvna monohrafiia [Babesiosis: A collective monograph]. FOP Brovin O. V., Kharkiv, 204 (in Ukrainian). doi 10.11603/1681-2727.2020.1.11112
23. Poriadok provedennia naukovymy ustanovamy doslidiv, eksperymentiv na tvarynakh. (2012). Ofitsiinyi visnyk Ukrainy, 24, s. 82.
24. QL, Liu Z.J., & Yu P.F. (2015). Genetic characterization and molecular survey of Babesia bovis, Babesia bigemina and Babesia ovata in cattle, dairy cattle and yaks in China. Parasites & Vectors., 8, 518.
25. Rjeibi, M. R, Darghouth, M. A, & Gharbi, M. (2016). Prevalence of Theileria and Babesia species in Tunisian sheep. Onderstepoort J Vet Res., 24;83(1), a1040. doi: 10.4102/ojvr.v83i1.1040.
26. Rouatbi, M., Romdhane, R., Bouaicha, F., Sassi, L., Dhibi, M., Rekik, M., Aynalem, H., Mwacharo J. M., Rischkowsky B., Darghouth M.A., & Gharbi M. (2020). Individual variability among autochthonous sheep in Northern Tunisia to infection by abomasum nematodes and Babesia/Theileria parasites. Vet Med Sci., 6(4), 834–845. doi: 10.1002/vms3.310.
27. Sevinc, F., Turgut, K., Sevinc, M., Ekici, O.D., Coskun, A., Koc, Y., Erol, M., & Ica, A. (2007). Therapeutic and prophylactic efficacy of imidocarb dipropionate on experimental Babesia ovis infection of lambs. Vet Parasitol., 149(1–2), 65–71. doi: 10.1016/j.vetpar.2007.07.014
28. Sevinc, F., Mo, Z., Shinuo, C., Ceylan, O., Aydin, M. F., Mutlu, S., & Xuenan, X. (2018). Haemoparasitic agents associated with ovine babesiosis: A possible negative interaction between Babesia ovis and Theileria ovis. Vet Parasitol., 15(252), 143–147. doi: 10.1016/j.vetpar.2018.02.013.
29. Shayan, P., Hooshmand., E., Nabian, S., & Rahbari, S. (2008). Biometrical and genetical characterization of large Babesia ovis in Iran. Parasitol Res., 103, 217–221. doi.org/10.1007/s00436-008-0960-1
30. Sivakumar, T. Tuvshintulga Bumduuren, Silva Seekkuge S P, Ybañez Adrian P, Ybañez Rochelle H D, Benitez Daniel F, Tayebwa Dickson S, De Macedo Alan C C, Schnittger Leonhard, Yokoyama Naoaki (2020). Host range and geographical distribution of Babesia sp. Mymensingh. Transbound Emerg Dis., 13. doi: 10.1111/tbed.13546.
31. Sivakumar, T., Tuvshintulga, B., Zhyldyz, A., Kothalawala, H., Yapa, P.R., Kanagaratnam, R., Vimalakumar, S.C., Abeysekera, T.S., Weerasingha, A.S., Yamagishi, J., Igarashi, I., Silva, S.S.P. & Yokoyama, N. (2018). Genetic analysis of Babesia isolates from cattle with clinical babesiosis in Sri Lanka. J. Clin. Microbiology, 56(11), e00895–18. doi: 10.1128/JCM.00895-18.
32. Tian, Z., Liu G, Yin, H., & Tian, M. (2013). Discrimination between ovine Babesia and Theileria species in China based on the ribosomal protein S8 (RPS8) gene. Vet. Parasitol., 197 (1–2), 354–359. doi: 10.1016/j.vetpar.2013.04.033.
33. Wang, T., Guan, G., Korhonen, P. K, Koehler, A. V., Young, N. D, Hall, R. S, Yin, H., & Gasser, R. B (2017). Mitochondrial genomes of two Babesia taxa from sheep in China as a foundation for population genetic and epidemiological investigations. Infect Genet Evol., 47, 51–55. doi: 10.1016/j.meegid.2016.11.002.
Published
2021-11-29
How to Cite
Kasianenko, O. I. ., NechyporenkoО. L., Risovaniy, V. I., Rebenko, H. I., Negreba, Y. V., Horodnycha, T. L., & Yeboah, S. O. (2021). BABESIOSIS OF SHEEP (DISTRIBUTION, COURSE, TREATMENT). Bulletin of Sumy National Agrarian University. The Series: Veterinary Medicine, (3 (54), 11-16. https://doi.org/10.32845/bsnau.vet.2021.3.2
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