CONSEQUENCES OF BACTERICIDAL EFFECT OF DIOLIDE DISINFECTANT ON TEST OBJECTS WITH SIMULATION OF PROTEIN CONTAMINATION
Keywords:
«Diolaid» disinfectant, imitation of protein contamination, test objects, bactericidal efficacy, Pseudomonas aeruginosa ATCC 15442, Staphylococcus aureus ATCC 25923
Abstract
The poultry industry of Ukraine needs rapid modernization to reduce the cost of production in compliance with high standards of its quality. The set of measures required for this includes the introduction of the latest environmental technologies and environmental protection of birds, animals, humans and the environment, which can be ensured by quality disinfection using new effective, safe and cheap disinfectants. The new Disinfectant disinfectant is able to meet the following requirements, according to the results of laboratory tests to determine its optimal concentrations in the simulation of protein contamination using test objects in the form of tiles, which were applied daily test cultures separately Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 15442 and sterile inactivated bovine serum as a protein contaminant. Investigation of working solutions «Diolide» 0.04 % (100 mg / dm3 for chlorine dioxide); 0.06 % (150 mg / dm3); 0.1 % (250 mg / dm3) and 0.16 % (400 mg / dm3) were similarly performed three times at exposures of 20, 30 and 60 minutes. After sowing and incubation, the effectiveness of different concentrations of the new disinfectant «Diolaid» was determined by its ability to ensure 99.99 % of the death of treated test bacteria. The results of the experiments showed the ineffectiveness of all working solutions of the new disinfectant at an exposure of 20 min, which was confirmed by the growth of test cultures in all crops. The use of exposure at 30 min was effective, because the action of working solutions, starting from 0.06 % and higher concentrations of disinfectant «Diolaid» was observed complete neutralization of test bacteria, as evidenced by the complete absence of their growth in media with intensive growth in controls. According to the analysis of the experiments, the most optimal concentration of the working dilution of the new disinfectant «Diolaid» was set at 0.06 % (150 mg / dm3 for chlorine dioxide), because its action for 30 min and longer in the simulation of protein contamination provided 100.0 % neutralization of test bacteria Pseudomonas aeruginosa ATCC 15442 and Staphylococcus aureus ATCC 25923.
References
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2. Breslavets, V. A., Pavlіchenko, O. V., Stegnіj, O. O. (2018). Suchasnі zasobi dlja dezіnfekcіjnoї obrobki іnkubacіjnih yaiets silskohospodarskoi ptytsi [Modern means for disinfection of hatching eggs of poultry]. Veterinary medicine, 2018, 104, 44–50. [in Ukrainian].
3. Chechet, O.M., Kovalenko, V. L., Harkavenko, T. O. & Horbatiuk, O. I., Kozytska, T. H. (2021). Efektyvnist robochykh rozchyniv dezinfektsiinoho zasobu “Biolaid” za dii na hramnehatyvni ta hrampozytyvni bakterii [The effectiveness of working solutions of disinfectant «Biolaid» for action on gram-negative and gram-positive bacteria]. Biology of creatures, 2021, 23(4), 64–72. DOI:org/10.15407/animbiol23.04.066. [in Ukrainian].
4. Carter, R, Joll, C A. (2017). Occurrence and formation of disinfection by-products in the swimming pool environment: A critical review. Journal of environmental sciences (China), 2017, 58, 19–50. DOI: 0.1016/j.jes.2017.06.013.
5. Du, Y., Lv, X. T., Wu, Q. Y., Zhang, D. Y., Zhou, Y. T., Peng, L., & Hu, H. Y. (2017) Formation and control of disinfection byproducts and toxicity during reclaimed water chlorination: A review. Journal of Environmental Sciences, 2017, 58, 51–63. DOI: 10.1016/j.jes.2017.01.013.
6. DSTU EN 1040:2004 „Zasoby khimichni dezinfektsiini ta antyseptychni. Osnovna bakterytsydna aktyvnist. Chastyna 1. Metod vyprobovuvannia ta vymohy (stadiia 1)”, metodyk YeS, nyni diiuchoho standartu DIN EN 1656:2010-03 «Khimichni dezinfektsiini ta antyseptychni zasoby – kilkisnyi suspenziinyi test dlia vyznachennia bakterytsydnoi aktyvnosti khimichnykh i antyseptychnykh zasobiv, yaki zastosovuiutsia v haluzi veterynarii – Metod vyznachennia ta vymohy (faza 2, krok 1)”. [DSTU EN 1040: 2004 “Chemical disinfectants and antiseptics. The main bactericidal activity. Part 1. Test method and requirements (stage 1) ”, EU methodologies, current standard DIN EN 1656: 2010-03 Chemical disinfectants and antiseptics – quantitative suspension test to determine the bactericidal activity of chemicals and antiseptics used in veterinary medicine – Method of determination and requirements (phase 2, step 1) ”.] [in Ukrainian].
7. Dorozhkin, V. I., Popov, N. I., Prokopenko, A. A. & Bochenin, Ju I. (2018). Jekologicheski bezopasnye dezinficirujushhie preparaty dlja obrabotki pomeshhenij i oborudovanija, kontaminirovannyh mikroorganizmami 2-j gruppy ustojchivosti. [Ecologically safe disinfectants for the treatment of premises and equipment contaminated with microorganisms of the 2nd resistance group]. Veterinarу. 2018, 4, 50–53. DOI: 10.30896/0042-4846.2018.21.4.50-53. [in Ukrainian].
8. Fotіna, G. A., Kovalenko, І. V. (2017). Eksperymentalni doslidzhennia dezinfektsiinoho zasobu SANTIM dlia peredinkubatsiinoi sanatsii yaiets. [Experimental studies of the effectiveness of SANSTIM disinfectant for pre-incubation remediation of eggs]. Biology of creatures, 2017, 103, 276–278. [in Ukrainian].
9. Hernández-Navarrete, M. J., Celorrio-Pascual, J. M., Lapresta Moros, C. & Solano Bernad, V. M. (2014). Fundamentos de antisepsia, desinfección y esterilización. Enfermedades infecciosas y microbiologia clinica, 32 (10), 681–688. https:// DOI:org/10.1016/j.eimc.2014.04.003.
10. Harkavenko, T O, Kovalenko, V L, Horbatiuk, O I, & Pinchuk, NH, Kozytska, T H, Harkavenko, V M, Ordynska, D O. (2020). Metodychni rekomendatsii z vyznachennia bakterytsydnoi aktyvnosti ta kontroliu vidsutnosti bakteriostatychnoho efektu dezinfikuiuchykh zasobiv. [Methodical recommendations for determining the bactericidal activity and control of the absence of bacteriostatic effect of disinfectants]. Kyiv: DNDILDVSE, 2020, 44 р. [in Ukrainian].
11. Iatsiv, S. F. (2021). Stan i perspektyvy rozvytku ptakhivnytstva u silskohospodarskykh pidpryiemstvakh Ukrainy. [Status and prospects of poultry development in agricultural enterprises of Ukraine]. Agrosvit, 2021, 16, 26–33. DOI: 10.32702/2306-6792.2021.16.26. [in Ukrainian].
12. Ivchenko, V. M. (2004). Dovidnyk sanitarno-mikrobiolohichnykh metodiv doslidzhen kharchovykh produktiv ta obiektiv dovkillia [Handbook of sanitary-microbiological methods of research of products and objects of environment]. Bila Church: 2004. 36 р. [in Ukrainian].
13. Iakubyk, O. L., Lytvynova, Z. A. (2022). Mikrobnaya obsemenennost ob’ektov promyishlennogo ptitsevodstva. [Microbial contamination of industrial poultry facilities]. Veterinary, 2022, 2, 44–47. DOI:10.30896/0042-4846.2022.25.2.44-47. [in Russian].
14. Jui-Wen Ma, Bin-Syuan Huang, Chu-Wei Hsu & Chun-Wei Peng, Ming-Long Cheng, Jung-Yie Kao, Tzong-Der Way, Hao-Chang Yin, Shan-Shue Wang. (2017). Efficacy and Safety Evaluation of a Chlorine Dioxide Solution. Int J Environ Res Public Health, 2017, 14(3), 329. DOI: 10.3390/ijerph14030329.
15. Kucheruk, M. D. (2019). Orhanichne ptakhivnytstvo: osnovni vymohy [Organic poultry: basic requirements]. Today’s poultry, 2019, 11/12, 9–10. [in Ukrainian].
16. Kochysh, Y. Y., Smolenskyi, V. Y., Nuralyev, E. R. & Kochysh, O. Y. (2020). Kompleksnaya programma obespecheniya biologicheskoy bezopasnosti promyishlennyih ptitsevodcheskih hozyaystv yaichnogo napravleniya. [A comprehensive program for ensuring the biological safety of industrial poultry farms for egg production]. Veterinary, 2020, 2, 8–13. DOI:10.30896/0042-4846.2020.23.2.08-13. [in Russian].
17. Lahotiuk, V.O. (2020). Osoblyvosti formuvannia stratehii zabezpechennia konkurentospromozhnosti pidpryiemstv haluzi ptakhivnytstva zalezhno vid kupivelnoi spromozhnosti spozhyvachiv [Peculiarities of forming the strategy of ensuring the competitiveness of poultry enterprises depending on the purchasing power of consumers]. Agrosvit, 2020, 1, 77–82. DOI: 10.32702/2306-6792.2020.1.77. [in Ukrainian].
18. Liulin, P. V., Severyn, R. V. , Hontar, A. M. (2021). Doslidzhennia sorbtsiinykh ta dezinfikuiuchykh vlastyvostei osushuvacha pidstylky «Mikadez» [Investigation of sorption and disinfection properties of Mikadez substrate drying]. Veterinary science, animal technology and nature conservation, 2021, (7), 63–67. https://oys.hdzva.edu.ua/doi:10.31890/vttp.2021.07.10. [in Ukrainian].
19. Montagna, M. T., Triggiano, F., Barbuti, G. & Bartolomeo, N., De Giglio, O., Diella, G. (2019). Study on the In Vitro Activity of Five Disinfectants against Nosocomial Bacteria. Int J Environ Res Public Health, 2019, 16 (11), 1895. DOI: 10.3390/ijerph16111895.
20. Nykolaenko, V. P., Shestakov, Y. N., Kononov, A. N. & Ozheredova, N. A., Mykhailova, A. V., Marchenko, V. V. (2019). Preparat Nykosan-aroma dlia dezynfektsyy yayts v ynkubatoryy [Nikosan-aroma preparation for disinfection of eggs in the hatchery]. Veterynary, 2019, 2. 42–44. DOI:10.30896/0042-4846.2019.22.2.42. [in Russian].
21. Paliy, A.P., Rodionova, K. O., Braginec, M. V. & Paliy, A. P., Nalivayko, L. I. (2018). Sanitarno-gigienicheskaya otsenka proizvodstv myasopererabatyivayuschih predpriyatiy i ih sanatsiya. [Sanitary-hygienic evaluation of meat processing enterprises productions and their sanation]. Ukrainian Journal of Ecology, 2018, 8 (2), 81–88. DOI: 10.15421/2018_313. [in Ukrainian].
22. Palii, A. P., Vedmid, O. V., Doletskyi, S. P. & Balym Yu. P. (2015). Poshuk dezinfikuiuchykh preparativ dlia borotby z tuberkulozom silskohospodarskykh tvaryn. [Search for disinfectants to combat tuberculosis in farm animals]. Veterinary medicine, 2015, 100, 109–112. Rezhym dostupu: http://www.jvm.kharkov.ua/sbornik/100/4_28.pdf. [in Ukrainian].
23. Palii. A. P., Stehnii. B. T., Zavhorodnii. A. I. & Huzhvynska. S. O. (2017). Suchasnyi dezinfikuiuchyi preparat dlia veterynarnoi medytsyny, [Modern disinfectant for veterinary medicine]. Veterinary medicine, 2017, 103, 63–65. [in Ukrainian].
24. Polehenka, M.A. (2019). Analiz suchasnoho stanu vyrobnytstva produktsii ptakhivnytstva v Ukraini [Analysis of the current state of production of poultry products in Ukraine]. Economy and power, 2019, 3, 137–143. DOI: 10.32702/2306-6806.2019.3.137. [in Ukrainian].
25. Paquette, C. C., Scheman, K. A., Ward, M. P. (2020). Knowledge and attitudes of Australian livestock producers concerning biosecurity practices. Australian veterinary journal, 98(11), 533–545. https://doi.org/10.1111/avj.13005.
26. Rabenau, H. F., Schwebke, I., Blümel, J. (2020). Guideline for testing chemical disinfectants regarding their virucidal activity within the field of human medicine. Bundesgesundheitsbl, 63, 645–655. https://doi.org/10.1007/s00103-020-03115-w.
27. Rodіonov, K. O. (2016). Znachennia vyrobnychoi sanitarii i systemy upravlinnia bezpechnosti kharchovykh produktiv (KhASSP). [Significance of hygienic sanitation and control systems for the safety of food products (HACCP)]. Veterinary medicine, 2016, 102, 217–219. [in Ukrainian].
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Published
2022-06-29
How to Cite
Chechet, O. M., Kovalenko, V. L., Gorbatyuk, O. I., Gaidei, O. S., Kravtsova, O. L., Andriyashchuk, V. O., Musiets, I. V., & Ordynska, D. O. (2022). CONSEQUENCES OF BACTERICIDAL EFFECT OF DIOLIDE DISINFECTANT ON TEST OBJECTS WITH SIMULATION OF PROTEIN CONTAMINATION. Bulletin of Sumy National Agrarian University. The Series: Veterinary Medicine, (1 (56), 37-44. https://doi.org/10.32845/bsnau.vet.2022.1.6
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