THE STATE OF METABOLIC PARAMETERS OF THE BLOOD IN WHITE RATS UNDER CONDITIONS OF LONG-TERM ORAL ADMINISTRATION OF LANTANUM ORTHOVANADATE NANOPARTICLES UNDER FOOD STRESS
Keywords:
lantanum orthovanadate nanoparticles; feed stress; aminotransferases; lipid peroxidation; white rats; cytotoxicity; adaptogenic action
Abstract
Based on the proven protective properties of nanoparticles of lanthanum orthovanadate activated by europium (NP LaVO4:Eu3+), a possible direction of their application is the use as a feed additive, since inorganic (oxides, chlorides, nitrates) and organic (citrates, fodder yeast, enriched) lanthanum is already are used in the world animal husbandry, positively affecting the growth qualities of pigs and broiler chickens, egg productivity of laying hens, improve the daily gain and milk production of cattle, the digestibility of nutrients in the diet of sheep. However, the effectiveness of the feed additive implies a long-term introduction into the body of animals and should be confirmed by an improvement in the state of the body under conditions of a stress factor. Therefore, the purpose of this work was to study the state of metabolic parameters of the blood of rats with subchronic oral intake of lanthanum orthovanadate nanoparticles against the background of feed stress. Experimental samples of NP LaVO4:Eu3+ (rod-shaped geometry; size 8×80 nm; initial concentration 1.0 g/dm3) were used in the work. Experimental studies on rats were carried out on the basis of the vivarium of the NSC «IEKVM». The object of research was 140 mature male Wistar rats with an initial weight of 220–230 g were used as the object of research. Four groups of animals, 35 rats each, were formed according to the principle of analogues. During the experiment, animals of the control group received drinking water without additives; rats of the experimental group I were fed with a solution of NP LaVO4:Eu3+ at a dose of 0.2 mg/dm3 (≈0.03 mg/kg of body weight); II experimental group - at a dose of 1.0 mg/dm3 (≈ 0.15 mg/kg body weight) and rats III experimental group – at a dose of 2.0 mg/dm3 (≈ 0.30 mg/kg body weight). Drinking was carried out for 56 days, then it was completed and the rats were observed for another 14 days. An unbalanced diet for nutrients was used as a stress factor. As a result of the work, it was found that under feed stress NP LaVO4:Eu3+ in doses of 0.2 and 1.0 mg/dm3 of drinking water (≈0.03 and ≈0.15 mg/kg of body weight) have an adaptogenic effect on the body of whites. rats with the optimal period of application – 56 and 28 days, respectively. However, long-term oral administration of NP LaVO4:Eu3+ at a dose of 2.0 mg/dm3 of drinking water (≈0.30 mg/kg of body weight) in rats has a hepato(cyto-)toxic effect, which is irreversible and is accompanied. The prospect of further research in this direction is to determine the distribution of Lanthanum in the body of white rats under food stress.
References
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18. Fang J, Huang Y, & Gong H. (1994). A study of feeding rare earth elements to black-bone silky fowl. Fujian J. Husb. Vet., 3, 28-9.
19. Goc, A. (2006). Biological activity of vanadium compounds. Open Life Sciences, 1(3). 314–332 https://doi.org/10.2478/s11535-006-0029-z
20. Greulich, C., Braun, D., Peetsch, A., Diendorf, J., Siebers, B., Epple, M., & Köller, M. (2012). The toxic effect of silver ions and silver nanoparticles towards bacteria and human cells occurs in the same concentration range. RSC Advances, 2(17), 6981. doi:10.1039/c2ra20684f
21. Grygorova, G. V., Klochkov, V. K., Sedyh, O. O., & Malyukin, Yu. V. (2013). Coagulation of Colloidal Solutions of Rod-Like Luminescent Nanoparticles nLaVO4: Eu3+. Chemistry, Physics and Technology of Surface, 4(2), 202-210.
22. Gruzewska, K., Michno, A., Pawelczyk, T., & Bielarczyk, H. (2014). Essentiality and toxicity of vanadium supplements in health and pathology. J. Physiol. Pharmacol. 65(5), 603-611.
23. Jia, H. Y., Liu, Y., Zhang, X. J., Han, L., Du, L. B., Tian, Q., & Xu, Y. C. (2009). Potential Oxidative Stress of Gold Nanoparticles by Induced-NO Releasing in Serum. Journal of the American Chemical Society, 131(1), 40–41. https://doi.org/10.1021/ja808033w
24. Joshi, M., Sodhi, K. S., & Pandeyetal, R. (2014). Cancer chemotherapy and hepatotoxicity: anupdate. IndoAm J Pharm Res, 4(6), 2976–2984.
25. Klochkov, V. K., Grigorova, A. V., Sedyh, O. O. & Yu.V. Malyukin (2012). Characteristics of nLnVO4 : Eu3+(Ln = La, Gd, Y, Sm) sols with nanoparticles of different shapes and sizes. J. Appl. Spectrosc., 79(5), 726-730. https://doi.org/10.1007/s10812-012-9662-7
26. Klochkov, V. K., Malyshenko, A. I., Sedykh, O. O., & Y. V. Malyukin (2011). Wet chemical synthesis and characterization of luminescent colloidal nanoparticles: ReVO4 : Eu3+(Re = La, Gd, Y) with rodlike and spindlelike shape. Functional materials, 18(1), 111-115. http://dspace.nbuv.gov.ua/handle/123456789/135437
27. Kutsan, O. T., Romanko, M. Ie., Orobchenko, O. L., & Ushkalov, V. O. (2016). Toksyko-biokhimichna otsinka nanometaliv za systemnymy markeramy pry zastosuvanni u veterynarnii medytsyni [Toxico-biochemical assessment of nanometals by systemic markers when used in veterinary medicine]. Kharkiv: NTMT. 328. (in Ukrainian)
28. Liu, Q., Wang, C., Huang, Y. X., Dong, K. H., Yang, W. Z., & Wang, H. (2008). Effects of lanthanum on rumen fermentation, urinary excretion of purine derivatives and digestibility in steers. Animal Feed Science and Technology, 142(1-2), 121–132. https://doi.org/10.1016/j.anifeedsci.2007.08.002
29. Maliukina, M. Iu., Piliai, L. V., Siedykh, O.O., Klochkov, V. K., & Kavok, N.S. (2018). Ahrehatsiina stiikist nanochastynok na osnovi ridkisnozemelnykh elementiv v riznomu mikrootochenni ta biolohichnykh seredovyshchakh [Aggregation stability of nanoparticles based on rare earth elements in various microenvironments and biological environments]. Biofizychnyi visnyk, (40), 5-16. https://doi.org/10.26565/2075-3810-2018-40-01 (in Ukrainian)
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Published
2023-06-06
How to Cite
Masliuk, A. V., Orobchenko, O. L., Romanko, M. Y., Klochkov, V. K., Yefimova, S. L., Kavok, N. S., & Kurbatska, O. V. (2023). THE STATE OF METABOLIC PARAMETERS OF THE BLOOD IN WHITE RATS UNDER CONDITIONS OF LONG-TERM ORAL ADMINISTRATION OF LANTANUM ORTHOVANADATE NANOPARTICLES UNDER FOOD STRESS. Bulletin of Sumy National Agrarian University. The Series: Veterinary Medicine, (1(60), 63-73. https://doi.org/10.32782/bsnau.vet.2023.1.11
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