DETERMINATION OF THE IMMUNOSTIMULATORY EFFECT OF THE DRUG “INCOMBIVIT”

Abstract

Recently, much attention has been paid to the study of the immune system of animals. In recent years, with immunodeficiency of animals, pharmacological immunocorrection through the use of immunomodulators has become increasingly important. Strong selection in search of higher growth rates of broilers has led to such side effects as metabolic disorders, low reactivity of the immune system. Insufficient supply of nutrients can weaken the immune system. It is safer to increase the immune potential of animals is the use of vitamins, minerals and other adaptogens. The level of acquired immunity depends on many factors, especially at the time of vaccination or infection. Vaccines interact with the immune system, eliciting the same immune response as in natural infection in birds. There are various ways to deliver antigens to chickens for immunization. In recent years, with immunodeficiency in animals, pharmacological immunocorrection has become increasingly important through the use of immunomodulators of various natures, which can increase or decrease the level of immune response. The use of methods of stimulating immune function in animals in veterinary medicine is explained by the fact that in the conditions of industrial animal husbandry, animals often have immunodeficiency, as a result of which they are susceptible to various diseases. Immunomodulation is performed to increase the productivity of chickens, increase the body’s resistance to pathogens. For this purpose, we used the drug "Incombivit". It is a combination drug that contains fat – and water –soluble vitamins, trace elements and amino acids that normalize metabolism, increase overall resistance, improve productivity, safety and reproductive function of animals. The preparation contains only endogenously available biologically active substances that are a natural components of animal feed and are naturally present in animal tissues. Studies of the drug "Incombivit" were conducted in identical conditions of the control and experimental groups. The experimental drug was fed through the water supply system after filling the poultry house, and while vaccinating livestock. Laboratory tests of serum samples were performed. There was an increase in the number of B –, T – lymphocytes, globulins, hemoglobin, total serum protein and other indicators, indicating an enhanced process of antibody production after immunization.