RELEVANCE OF SPECIFIC IG E ALLERGY MARKER DETERMINATION IN THE DIAGNOSIS OF ATOPIC DERMATITIS IN DOGS

Abstract

In dogs with atopic dermatitis, intradermal testing (IDT) or an allergen-specific serological IgE test is routinely used to identify causative allergens. These allergens can then be used for allergen-specific immunotherapy and allergy treatment. The clinical significance of this testing is influenced by the allergen source, and other biomarkers that are more closely related to specific allergens remain to be determined. The purpose of the study was to examine dogs of five breeds for the diagnosis of atopic dermatitis and to determine the specific IgE allergy marker. The research was conducted in the conditions of a private veterinary clinic. The diagnosis of the nosological form of skin lesions was established based on the results of the anamnesis collection and the clinical manifestation of the disease. In addition, laboratory tests of the blood of sick dogs were carried out. Research has established that allergic dermatitis is more often diagnosed in Sharpei, Great Dane, Pekingese and Chow Chow breeds. Gender dependence of dermatitis cases has not been proven. Atopic dermatitis was diagnosed in males and females aged 5-8 years, which was almost 30%. Atopic dermatitis was diagnosed in 20% of Pekingese and Great Dane breeds in three males and one female, respectively. Among the selected five blood samples, the level of the allergy marker specific IgE was detected in three animals to the dust mite Dermatophagoides farinae, to the mold fungus Malassezia was detected in samples 3 and 4 at the level of the first class, to ambrosia pollen (ragweed) in three samples, Ig E to fleas (flea) was present in four samples. The allergy marker to the barn mite Tyrophagus putrescentiae was detected in only two samples. Research has proven the fact of the occurrence of atopic dermatitis associated with a violation of the integrity of the skin. Markers (Ig E) were absent for pollen of birch, alder, hazel, for pollen of platane, willow, poplar, for pollen of Parietaria, for a mixture of 6 grasses (dactylis , meadow sawdust, ordinary meadow grass, English ryegrass, timothy, velvet grass), to stinging nettle pollen, to lambs quarter pollen, to plantain pollen, to mugwort pollen, to pollen sorrel.The prospect of further research in this direction is the development of drugs capable of restoring the skin barrier and increasing natural protection against pathogenic organisms.