Особливості застосування екстракту glycyrrhiza у птахівництві
Ключові слова:
екстракт гліциризу, фітогенні препарати, антиоксидант, антибактеріальний, противірусний, протипухлинний, протизапальний, продуктивність, птахівництво.
Анотація
У статті наведені дослідження впливу фітогенних препаратів на імунну систему та продуктивність сільськогосподарських тварин. Аналізуючи світову тенденцію щодо зацікавленості фітогенними рослинними препаратами, в статті представлені дослідження найбільш популярного препарату - glycyrrhiza. Даний препарат - це один з компонентів традиційних китайських лікувальних засобів. Glycyrrhiza має властивості бадьорості ци, використовується для профілактики роботи селезінки, має відхарклювальні властивості та сприяє полегшенню кашлю, діє як жарознижуюче, використовується при детоксикації, при цьому сумісний з багатьма лікарськими препаратами. Традиційно даний препарат використовували для профілактики й лікування людини - як протипухлинні, протизапальні, противірусні засоби, також використовували для догляду за шкірою. Відомо, що залишки glycyrrhiza в продуктах тваринного походження не мають побічної дії на організм людини, і цей факт ще більше привертає увагу до більш широкого використання glycyrrhiza в сучасному тваринництві. Однак, деякі активні компоненти glycyrrhiza, на цей час вивчені не до кінця. Також вивчається процес екстракції. Механізм стійкості до хвороб і лікування даним препаратом, на сьогоднішній день, не дуже зрозумілі. Внаслідок чого, препарат не отримав широкого поширення в тваринництві та птахівництві. Glycyrrhiza містить тритерпенові сапоніни, флавоноїди, полісахариди та інші корисні для організму біологічно активні речовини. Має унікальний комплекс властивостей, таких як: антиоксидантної, антибактеріальної, противірусної, протипухлинної, протизапальної, а також має здатність до регуляції імунної та біологічної активності організму, контроль рівня цукру в крові - все це і привертає увагу до себе. У статті розглядається хімічний склад, механізм дії і застосування glycyrrhiza в птахівництві. Основна мета дослідження - сформулювати рекомендації щодо застосування екстракту glycyrrhiza в птахівництві.
Посилання
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2. Xiang Jing. Research on the effect of glycyrrhiza miRNA on gene expression profile of human immune cells[D]. Guangdong Pharmaceutical University, 2017.
3. Deng Taomei, Peng Can, Peng Daiyin, Yu Nianjun, Chen Weidong, Wang Lei. Research progress on the chemical constituents and pharmacological effects of glycyrrhiza and discussion of quality markers [J]. Chinese Journal of Chinese Materia Medica, online first, 2021-03-08
4. Tian Wusheng. The chemical composition and clinical research overview of glycyrrhiza [J]. Clinical Research of Traditional Chinese Medicine, 2012, 4(16): 31-32.
5. Smith Peter Andrey. The tantalizing links between gut microbes and the brain.[J]. Nature, 2015, 526(7573) : 312-4.
6. Seon M R , Park S Y , Kwon S J , et al. Hexane/ethanol extract of Glycyrrhiza uralensis and its active compound isoangustone A induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells[J]. Journal of Nutritional Biochemistry, 2012, 23(1):85-92.
7. Xu Shumei, Zhou Lei, Liu Zhuogang, Chen Bo, Li Yang. Glycyrrhetinic acid induces U266 cell apoptosis and its effect on Survivin expression[J]. Chinese Journal of Experimental Hematology, 2011,19(03):652-655 .
8. Lee CS,Kim YJ,Lee MS,et al. 18β-Glycyrrhetinic acid induces apoptotic cell death in SiHa cells and exhibits a synergistic effect against antibiotic anti-cancer drug toxicity[J]. Life Sciences, 2008, 83(13-14):481-489.
9. Xiao X Y , Hao M , Yang X Y , et al. Licochalcone A inhibits growth of gastric cancer cells by arresting cell cycle progression and inducing apoptosis[J]. Cancer Letters, 2011, 302(1):69-75.
10. Chu X T , Cruz J D L , Hwang S G , et al. Tumorigenic effects of endocrine-disrupting chemicals are alleviated by glycyrrhiza (Glycyrrhiza glabra) root extract through suppression of AhR expression in mammalian cells.[J]. Asian Pacific Journal of Cancer Prevention Apjcp, 2014, 15(12):4809-13.
11. Yan Shu, Gu Dawei, Chen Zhimin, Zhou Ming, Shi Hui, Wang Yang, Wu Yuchen, Cai Yunqing. Glycyrrhizin inhibits the invasion and metastasis of human melanoma A375 cells by regulating miRNA[J]. Journal of Nanjing Medical University (Natural Science Edition) ), 2015, 35(02):263-269.
12. Yuxin L , Sirou X , Yu W , et al. Liquiritigenin Inhibits Tumor Growth and Vascularization in a Mouse Model of Hela Cells[J]. Molecules, 2012, 17(6):7206-7216.
13. Wang Y, Xie S, Liu C, et al . Inhibitory Effect of Liquiritigenin on Migration Via Downregulation ProMMP-2 and PI3K/Akt Signaling Pathway in Human Lung Adenocarcinoma A549 cells[J]. Nutrition & Cancer, 2012, 64(4):627-634.
14. Ma J , Fu N Y , Pang D B , et al. Apoptosis induced by isoliquiritigenin in human gastric cancer MGC-803 cells.[J]. Planta Medica, 2001, 67(08):754-757.
15. Wang Cunliang. Anti-tumor effect of combination of glycyrrhiza flavonoids and cyclophosphamide[J]. Chinese Journal of Hospital Pharmacy, 2011(22):1877-1880.
16. Tao Yuzhu. Study on the effects of Codonopsis pilosula and glycyrrhiza extracts on the signal pathway of IEC-6 cell migration polyamine regulation [D]. Guangzhou University of Traditional Chinese Medicine, 2013.
17. Si-Rou, Xie, Yu, et al. Liquiritigenin Inhibits Serum-induced HIF-1α and VEGF Expression via the AKT/mTOR-p70S6K Signalling Pathway in HeLa Cells[J]. Phytotherapy Research, 2011.
18. Zhang Yiping. Research on mechanism of glycyrrhizin biotransformation and prevention and treatment of tumors and chronic liver injury[D]. 2016.
19. Hong Y K , Wu H T , Ma T , et al. Effects of Glycyrrhiza glabra polysaccharides on immune and antioxidant activities in high-fat mice[J]. International Journal of Biological Macromolecules, 2009, 45(1):61-64.
20. Kang Jinsen, Cheng Lufeng, Yang Jian, Tao Yicun, Hu Jian. The effect of total flavonoids of glycyrrhiza on skin aging[J]. Shandong Medicine, 2012, 52(42): 34-35.
21. Sun Guoqing, Luo Zhengli. Anti-aging effect of glycyrrhizin on aging model rats[J]. Chinese Journal of Gerontology, 2014, 34(07): 1895-1896.
22. Lian Yijun, Liu Hong, Ma Yanmei, Sun Ping, Li Bingqi. Study on the separation, purification and antioxidant activity of polysaccharides from glycyrrhiza residue with macroporous resin[J]. Journal of Shihezi University (Natural Science Edition), 2015, 33(03) ):351-356.
23. Chang Jing. Study on the extraction, content determination and antioxidant activity of flavonoids in glycyrrhiza [D]. North University of China, 2014.
24. Xue Wei. Extraction, structure analysis and activity study of glycyrrhiza polysaccharides[D]. Tianjin University of Science and Technology, 2019.
25. Liu Jiao. Study on the effect of Dioscorea opposita with glycyrrhiza on oxidative stress and the expression of CYP1A2 and CYP2E1 protein in rat liver[D]. Fujian University of Traditional Chinese Medicine, 2014.
26. Kim Y W , Kim Y M , Yang Y M , et al. Inhibition of LXRα-Dependent Steatosis and Oxidative Injury by Liquiritigenin, a glycyrrhiza Flavonoid, as Mediated with Nrf2 Activation.[J]. Antioxidants & Redox Signaling, 2011.
27. Hu Huiping. Research progress on the antiviral effects of glycyrrhiza[J]. China Journal of Traditional Chinese Medicine, 2004, 15(8): 6-10.
28. Shen Qiaofeng. Comparison of the efficacy of different glycyrrhizic acid drugs in the treatment of chronic hepatitis B[J]. Strait Pharmacy, 2012, 24(07):101-103.
29. Wu Chengjiu. Observation on the curative effect of compound glycyrrhizin on chronic hepatitis B[J]. China Journal of Modern Medicine, 2012, 14(10): 25-27.
30. Liu Hualong. Study on the efficacy of compound glycyrrhizin in the treatment of chronic hepatitis B against liver fibrosis[J]. Journal of Clinical Rational Use, 2012, 5(24): 10-11.
31. Zhao Fei, Zhang Fengbin, Zhou Yonghong, Zhang Li, Wang Yingying, Zhang Ruixing. Observation on the effect of diammonium glycyrrhizinate on liver injury induced by carbon tetrachloride in rats[J]. Liver, 2012, 17(02): 115-117 .
32. Renjie L , Shidi S , Changsen S . Protective effect of Glycyrrhiza glabra polysaccharides against carbon tetrachloride-induced liver injury in rats[J]. African Journal of Microbiology Research, 2010, 4(16):1784-1787.
33. Chen Yunhua, Wan Xin, Sun Jianning, Wang Wenquan, Zhang Shuofeng. Comparison of the protective effects of glycyrrhizic acid, glycyrrhizin, and isoliquiritin on acetaminophen human liver cell injury model[J]. Chinese Journal of Experimental Prescriptions, 2012, 18 (04):245-248.
34. Jing Jing. Research on the Intervention Effect and Mechanism of Total Flavonoids of glycyrrhiza on Non-alcoholic Fatty Liver[D]. Ningxia Medical University, 2015.
35. Huang Qunrong, Ma Zhe. Research progress on the pharmacological effects of glycyrrhizic acid[J]. Drug Evaluation Research, 2011, 34(05):384-387.
36. Liu Liping, Ren Cuiai, Zhao Hongyan. Research progress in the immunomodulatory effects of glycyrrhizic acid[J]. Chinese Journal of Experimental Formulas, 2010, 016(006):272-276.
37. Li Entao. Preparation of glycyrrhiza Polysaccharide Liposomes and Study on Its Immunoenhancing Effect[D]. Nanjing Agricultural University, 2016.
38. Wang Lirong, Li Jie, Dong Yongjun, Hang Bolin, Liu Xingchang. The effect of glycyrrhiza polysaccharides on the growth performance and cellular immunity of mice[J]. Northwest Agricultural Journal, 2007(01): 220-222.
39. Hong Y K , Wu H T , Ma T , et al. Effects of Glycyrrhiza glabra polysaccharides on immune and antioxidant activities in high-fat mice[J]. International Journal of Biological Macromolecules, 2009, 45(1):61-64.[J].Agricultural Science & Technology,2008(02):129-131.
40. Li Fasheng, Zhao Jue, Chi Xiaofeng, Yang Bo, Yan Xiaomei, Liu Hairi. The effect of glycyrrhiza polysaccharide on immune regulation in mice[J]. China Journal of Information on Traditional Chinese Medicine, 2009, 16(06): 35-36 .
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Опубліковано
2021-05-31
Як цитувати
Бордунова , О., Вечорка , В., Лю , Ч., Кисельов , О., & Самохіна , Є. (2021). Особливості застосування екстракту glycyrrhiza у птахівництві. Вісник Сумського національного аграрного університету. Серія: Тваринництво, (2 (45), 54-61. https://doi.org/10.32845/bsnau.lvst.2021.2.8
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