EFFECT OF IRON(IV) CLATROCHELATE ON CERULOPLASMIN CONTENT IN BLOOD SERUM OF PIGLETS
Keywords:
anemia, iron, hexahydrazide clatrochelate, ceruloplasmin, piglets, sows
Abstract
The body of piglets has biological features that determine their susceptibility to iron deficiency anemia. This is due to the fact that hemocytopoietic processes in their body do not provide sufficient production of erythrocytes and hemoglobin synthesis. Along with the use of iron-containing drugs for the prevention of iron deficiency, the risk of activation of lipid peroxidation increases. To achieve this goal, 2 groups of newborn piglets-analogues were formed during their retention with suckling sows − control and experimental, 15 animals in each. The experiment lasted 30 days. The piglets in the experimental group were selected from sows given 10 ml of 10% iron (IV) clatrochelate solution and cyanocobalamin solution twice intramuscularly during pregnancy. The piglets of the control group according to the traditional scheme of prevention of iron deficiency anemia on the second day of life were administered iron dextran drug (at the rate of 200 mg of iron (III) per injection). The results show that during the most critical period for the development of iron deficiency anemia, оn the 9, 12 and 30 days of life of piglets in the experimental and control groups the differences in the dynamics of changes in the content of ceruloplasmin in the serum were not detected. The proposed scheme for the prevention of iron deficiency anemia based on intramuscular parallel administration of solutions of iron(IV) clatrochelate and cyanocobalamin to pregnant sows on the 14 and 7 days before the expected farrowing was effective, and in the absence of stillbirths and the clinical signs of anemia.
References
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2. Antipov, A. A., Del'cov, A. A., Sodboev, C. C., & ZHarov A. V. (2011). Rol' svobodnoradikal'nogo okisleniya v patogeneze zhelezodificitnoj anemii i ee farmakokorrekcii [The role of free radical oxidation in the pathogenesis of iron deficiency anemia and its pharmacological correction]. MGAVMiB – MVA imeni K. I. Skryabina. Moskva,15–19 [in Russian].
3. Antipov, A. A, & Zharov A. V. (2013). Histological and morphometric changes in the liver, kidneys, spleen and lymph nodes of piglets with alimentary iron deficiency anemia [Gistologicheskie i morfometricheskie izmeneniya pecheni, pochek, selezenki i limfaticheskih uzlov porosyat pri alimentarnoj zhelezodeficitnoj anemii]. Rossijskij veterinarnyj zhurnal. Sel'skohozyajstvennye zhivotnye [Russian veterinary journal. Farm animals], 1, 19–21 [in Russian].
4. Antonyak, G. L., Solohub, L. I., Snitynskyi, V. V., & Babych, N. O. (2006). Zalizo v orhanizmi lyudyny I tvaryn (biohimichni, imunolohichni ta ekolohichni aspekty) [Iron in humans and animals (biochemical, immunological and environmental aspects)]. Lviv [in Ukrainian].
5. Bahramov, S. M., Kazakbaev, H. M., & Buglanov, A. A. (2014). Transferrin: rol' v obmene zheleza i nekotorye aspekty [Transferrin: role in iron metabolism and some aspects]. Gematologija i transfuziologija [Hematology and transfusiology], 2, 39−42 [in Russian].
6. Belousova Y. B., Kukesa V. G., Lepahina V. K., & Petrova V. I. (Eds.) (2014). Clinical pharmacology: a national guide [Klinicheskaya farmakologiya: nacional'noe rukovodstvo]. Moskwa, Geotar-Media [in Russian].
7. Bonkovsky, S., & Herbert, L. (1991). Iron and the liver. The American journal of the medical sciences, 301(1), 32−43. doi.org/10.1097/00000441-199101000-00006
8. Buchko, O. M., Snitynskyi, V. V., Danchuk, V. V., & Antoniak H. L. (1998). Zastosuvanna spoluk selenu dlia profilaktyky oksydatsiinoho stresu u porosiat rannoho viku [The use of selenium compounds for the prevention of oxidative stress in early piglets of his age]. Haukovyi visnyk Hatsionalnoho Ahrarnoho universytetu [Scientific Bulletin of the National Agrarian University], 10, 156–163 [in Ukrainian].
9. Chen, J., Anderson., J., DeWeese-Scott, C., Fedorova, N., Geer, L., He, S., Hurwitz, D., Jackson, J., Jacobs, A., Lanczycki, Ch., Liebert, C., Liu, Ch., Madej, T., Marchler-Bauer, A., Marchler, G., Mazumder, R., Nikolskaya, A., Rao, B., Panchenko, A., Shoemaker, A., Simonyan, V., Song, J., Thiessen, P., Vasudevan, S., Wang, Y., Yamashita, R., Yin, J., Bryant, S. (2003). MMDB: Entrez's 3D-structure database, Nucleic Acids Research, 31, 1, 474–477, https://doi.org/10.1093/nar/gkg086
10. Danchuk, O. V. (2013). Peroksydne okysnennia lipidiv ta aktyvnist systemy antyoksydantnoho zakhystu u porosiatsysuniv pid vplyvom preparativ zaliza [Peroxidation of lipids and the activity of the antioxidant defense system in suckling piglets under the influence of iron preparations]. Svynarstvo [Swine breeding], 62, 89–93 [in Ukrainian].
11. Del'cov, A. A. Antipov, A.A. (2013). Morphological changes in the liver and kidneys of piglets with iron deficiency anemia [Morfologicheskie izmeneniya pecheni i pochek porosyat pri zhelezodeficitnoj anemii]. Veterinary [Veterinariya], 4, 46–49
12. Del'cov, A. A., Gurevichev, P.A. (2007). Study of toxicity parameters of new iron-dextran preparations [Izuchenie parametrov toksichnosti novyh zhelezodekstranovyh preparatov]. Materials of the II All-Russian Scientific and Practical Conference of Young Scientists "Youth and Science of the XXI Century" [Materialy II Otkrytoj Vserossijskoj nauchnoprakticheskoj konferencii molodyh uchenyh «Molodezh' i nauka XXI veka»]. Ul'yanovsk, 57–61.
13. Dorozhkin, V. I. (1996). Rezul'taty issledovanij biologicheskoj aktivnosti metionata medi [The results of research on the biological activity of media methonates]. Materialy nauchnoj konferencii, posvjashhennye 50-letiju Krasnodarskoj AIVS «Sostojanie i perspektivy razvitija nauchnyh issledovanij po profilaktike i lecheniju sel'skohozjajstvennyh zhivotnyh i ptic». Krasnodar, 91–92 [in Russian].
14. Droge, W., (2001). Free radicals in the physiological control of cell ruction. Physiological reviews, 82. 47–95.
15. Dukhnitsky, V. B., Derkach, I. M., Plutenko, M. O., Fritsky, I. O., & Derkach, S. S. (2018). Vyznachennja parametriv gostroi toksychnosti ferumu (IV) na bilyh myshah [Determination of the accumulative toxicity parameters of iron (IV) on white mice]. Ukrainian Journal of Ecology, 8 (2), 308–312. doi.org/10.15421/2018_343 [in Ukrainian].
16. Dukhnitsky, V. B., Derkach, I. M., Derkach, S. S., Fritsky, I.O., & Plutenko, M. O. (2019). Khronichna toksychnist klatrokhelatu Ferumu (IV) dlia bilykh shchuriv [Chronic toxicity of the Iron (IV) clathrochelate complexes for white rats]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 21(95), 15–21. https://doi.org/10.32718/nvlvet9503 [in Ukrainian].
17. Dukhnitsky, V. B., Derkach, I. M., Plutenko, M. O., Fritsky, I. O., & Derkach, S. S. (2019). Cumulative properties of Iron(IV) clathrochelate in rats [Kumuliatyvni vlastvosti klatrokhelatu Ferumu (IV) dlia bilykh shchuriv]. Visnyk PDAA [Messenger PDAA], 2, 238–246. doi: 10.31210/visnyk2019.02.32 [in Ukrainian].
18. Dukhnitsky, V. B., Derkach, I. M., Plutenko, M. O., Fritsky, I. O., & Derkach, S. S. (2019). Acute toxicity of the iron clathrochelate complexes. Regulatory Mechanisms in Biosystems, 10(3), 276–279. https://doi.org/10.15421/021942
19. Dukhnitsky, V. B., Derkach, I. M., Derkach, S. S., Plutenko, M. O. & Fritsky, I. O. (2019). Influence of iron (IV) clathrochelate complex on quail blood parameters and weight characteristics. Ukrainian Journal of Ecology, 9 (3), 126–131. DOI: 10.15421/2019_719
20. Dukhnitsky, V. B., Derkach, I. M., Derkach, S. S., Fritsky, I. O., & Plutenko, M. O. (2020). Doslidzhennia podrazniuvalnoi dii ta alerhennykh vlastyvostei klatrokhelatu Ferumu(IV) [Investigations of the irritant effect and allergenic properties of Fermat's clatrochelate (IV)]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 22(97), 130–135. doi: 10.32718/nvlvet9721 [in Ukrainian].
21. Dukhnitsky, V. B., Derkach, I. M., Derkach, S. S., Fritsky, I. O., & Plutenko, M. O. (2020). Doslidzhennia protyanemichnoi dii klatrokhelatu Ferumu(IV) na porosiatakh [Study of the antianemic effect of iron (IV) clatrochelate on piglets]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 22(99), 107–115. doi: 10.32718/nvlvet9917 [in Ukrainian].
22. Dukhnitsky, V. B., Kalachniuk L. H., Derkach, I. M., Derkach, S. S., Plutenko, M. O. & Fritsky, I. O. (2020). Iron(IV) hexahydrazide clathrochelate complexes: the chronic toxicity study. Ukrainian Journal of Ecology, 9 (3), 18–23. DOI: 10.15421/2020_3
23. Ganz, T. (2013). Systemic iron homeostasis. Physiological Reviews, 93 (4), 1721−1741. doi: 10.1152/physrev.00008
24. Gasanov, A. S., Amiov, D. R., Muhutdinova, D. M., Ovsjannikov, A. P., Churna, Z. G., & Shamsutdinova, N. V. (2020). Anemija i preparaty, primenjaemye pri ee lechenii i profilaktike [Anemia and drugs used in its treatment and prevention]. Kazan' [in Russian].
25. Gurevichev P. A., Del'cov A. A., & Urazaev D. N. (2007). Iron dextran preparations in veterinary medicine [Zhelezodekstranovye preparaty v veterinarii]. Materialy pervogo s"ezda veterinarnyh farmakologov Rossii [Proceedings of the first congress of veterinary pharmacologists of Russia]. Materialy s"ezda. Voronezh, 699 [in Russian].
26. Kang, J. O. (2001). Chronic iron overload and toxicity: clinical chemistry perspective. Clinical Laboratory Science Journal, 14 (3), 209-219.
27. Hrytsulia, M. (2020). Tseruloplazmin: praktychni aspekty zastosuvannia dlia pryskorenoho vidnovlennia patsiientiv khirurhichnoho profiliu [Ceruloplasmin: practical aspects of application for accelerated recovery of patients with a surgical profile]. Khirurhiia, Ortopediia, Travmatolohiia, Intensyvna terapiia [Surgery, Orthopedics, Traumatology, Intensive Care], 1, 39 [in Ukrainian].
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Published
2022-01-27
How to Cite
Derkach, I., DukhnitskyіV., Derkach, S., Fritsky, I., Plutenko, M., & LozovyіV. M. (2022). EFFECT OF IRON(IV) CLATROCHELATE ON CERULOPLASMIN CONTENT IN BLOOD SERUM OF PIGLETS. Bulletin of Sumy National Agrarian University. The Series: Veterinary Medicine, (2 (53), 26-32. https://doi.org/10.32845/bsnau.vet.2021.2.4
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Section
Veterinary medicine
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