ВПЛИВ КЛАТРОХЕЛАТУ ФЕРУМУ(IV) НА ВМІСТ ЦЕРУЛОПЛАЗМІНУ В СИРОВАТЦІ КРОВІ ПОРОСЯТ
Ключові слова:
анемія, ферум, гексагідразидний клатрохелат, церулоплазмін, поросята, свиноматки
Анотація
Організм поросят має біологічні особливості, які зумовлюють їх схильність до захворювання на ферумдефіцитну анемію. Це пояснюється тим, що гемоцитопоетичні процеси в їх організмі не забезпечують в достатній мірі продукування еритроцитів та синтез гемоглобіну. Поряд із застосуванням ферумвмісних препаратів для профілактики ферумдефіцитного стану зростає ризик активації перекисного окислення ліпідів. Тому за вивчення фармакотоксикологічних властивостей нових протианемічних лікарських засобів з діючою речовиною Ферум потребує дослідження прояв їх прооксидантних властивостей в організмі тварини. Для виконання поставленої мети було сформовано 2 групи новонароджених поросят-аналогів у період їх утримання зі свиноматками на підсосі – контрольна та дослідна, по 15 тварин у кожній. Дослід тривав 30 діб. Поросята дослідної групи були відібрані від свиноматок, яким в період вагітності двічі внутрішньом’язово вводили по 10 мл 10 % розчину клатрохелату Феруму(IV) та розчин ціанокобаламіну. Поросятам контрольної групи згідно традиційної схеми профілактики ферумдефіцитної анемії вводили ферумдекстрановий препарат (з розрахунку 200 мг Феруму(III) на одне введення). Результати досліджень засвідчують, що упродовж найбільш критичного для розвитку ферумдефіцитної анемії періоду, на 9, 12 та 30 доби життя поросят дослідної та контрольної груп, не було виявлено відмінностей у динаміці змін вмісту церулоплазміну у сироватці крові. Запропонована схема профілактики ферумдефіцитної анемії на основі внутрішньом’язового паралельного введення розчинів клатрохелату Феруму(IV) та ціанокобаламіну вагітним свиноматкам за 14 та 7 діб до очікуваного опоросу виявилась ефективною, причому за відсутності народження мертвих плодів та клінічних ознак анемії.
Посилання
1. Antipov, A. A. (2013). Patogeneticheskie mekhanizmy razvitiya, diagnostika i profilaktika alimentarnoj zhelezodeficitnoj anemii porosyat (Doctoral dissertation). Retrieved from Disser Cat – elektronnaya biblioteka dissertacij. https://www.dissercat.com/content / patogeneticheskie-mekhanizmy – razvitiya – diagnostika – i – profilaktika – alimentarnoi - zhelezodefits [in Russian].
2. Antipov, A. A., Del'cov, A. A., Sodboev, C. C., & ZHarov A. V. (2011). Rol' svobodnoradikal'nogo okisleniya v patogeneze zhelezodificitnoj anemii i ee farmakokorrekcii [The role of free radical oxidation in the pathogenesis of iron deficiency anemia and its pharmacological correction]. MGAVMiB – MVA imeni K. I. Skryabina. Moskva,15–19 [in Russian].
3. Antipov, A. A, & Zharov A. V. (2013). Histological and morphometric changes in the liver, kidneys, spleen and lymph nodes of piglets with alimentary iron deficiency anemia [Gistologicheskie i morfometricheskie izmeneniya pecheni, pochek, selezenki i limfaticheskih uzlov porosyat pri alimentarnoj zhelezodeficitnoj anemii]. Rossijskij veterinarnyj zhurnal. Sel'skohozyajstvennye zhivotnye [Russian veterinary journal. Farm animals], 1, 19–21 [in Russian].
4. Antonyak, G. L., Solohub, L. I., Snitynskyi, V. V., & Babych, N. O. (2006). Zalizo v orhanizmi lyudyny I tvaryn (biohimichni, imunolohichni ta ekolohichni aspekty) [Iron in humans and animals (biochemical, immunological and environmental aspects)]. Lviv [in Ukrainian].
5. Bahramov, S. M., Kazakbaev, H. M., & Buglanov, A. A. (2014). Transferrin: rol' v obmene zheleza i nekotorye aspekty [Transferrin: role in iron metabolism and some aspects]. Gematologija i transfuziologija [Hematology and transfusiology], 2, 39−42 [in Russian].
6. Belousova Y. B., Kukesa V. G., Lepahina V. K., & Petrova V. I. (Eds.) (2014). Clinical pharmacology: a national guide [Klinicheskaya farmakologiya: nacional'noe rukovodstvo]. Moskwa, Geotar-Media [in Russian].
7. Bonkovsky, S., & Herbert, L. (1991). Iron and the liver. The American journal of the medical sciences, 301(1), 32−43. doi.org/10.1097/00000441-199101000-00006
8. Buchko, O. M., Snitynskyi, V. V., Danchuk, V. V., & Antoniak H. L. (1998). Zastosuvanna spoluk selenu dlia profilaktyky oksydatsiinoho stresu u porosiat rannoho viku [The use of selenium compounds for the prevention of oxidative stress in early piglets of his age]. Haukovyi visnyk Hatsionalnoho Ahrarnoho universytetu [Scientific Bulletin of the National Agrarian University], 10, 156–163 [in Ukrainian].
9. Chen, J., Anderson., J., DeWeese-Scott, C., Fedorova, N., Geer, L., He, S., Hurwitz, D., Jackson, J., Jacobs, A., Lanczycki, Ch., Liebert, C., Liu, Ch., Madej, T., Marchler-Bauer, A., Marchler, G., Mazumder, R., Nikolskaya, A., Rao, B., Panchenko, A., Shoemaker, A., Simonyan, V., Song, J., Thiessen, P., Vasudevan, S., Wang, Y., Yamashita, R., Yin, J., Bryant, S. (2003). MMDB: Entrez's 3D-structure database, Nucleic Acids Research, 31, 1, 474–477, https://doi.org/10.1093/nar/gkg086
10. Danchuk, O. V. (2013). Peroksydne okysnennia lipidiv ta aktyvnist systemy antyoksydantnoho zakhystu u porosiatsysuniv pid vplyvom preparativ zaliza [Peroxidation of lipids and the activity of the antioxidant defense system in suckling piglets under the influence of iron preparations]. Svynarstvo [Swine breeding], 62, 89–93 [in Ukrainian].
11. Del'cov, A. A. Antipov, A.A. (2013). Morphological changes in the liver and kidneys of piglets with iron deficiency anemia [Morfologicheskie izmeneniya pecheni i pochek porosyat pri zhelezodeficitnoj anemii]. Veterinary [Veterinariya], 4, 46–49
12. Del'cov, A. A., Gurevichev, P.A. (2007). Study of toxicity parameters of new iron-dextran preparations [Izuchenie parametrov toksichnosti novyh zhelezodekstranovyh preparatov]. Materials of the II All-Russian Scientific and Practical Conference of Young Scientists "Youth and Science of the XXI Century" [Materialy II Otkrytoj Vserossijskoj nauchnoprakticheskoj konferencii molodyh uchenyh «Molodezh' i nauka XXI veka»]. Ul'yanovsk, 57–61.
13. Dorozhkin, V. I. (1996). Rezul'taty issledovanij biologicheskoj aktivnosti metionata medi [The results of research on the biological activity of media methonates]. Materialy nauchnoj konferencii, posvjashhennye 50-letiju Krasnodarskoj AIVS «Sostojanie i perspektivy razvitija nauchnyh issledovanij po profilaktike i lecheniju sel'skohozjajstvennyh zhivotnyh i ptic». Krasnodar, 91–92 [in Russian].
14. Droge, W., (2001). Free radicals in the physiological control of cell ruction. Physiological reviews, 82. 47–95.
15. Dukhnitsky, V. B., Derkach, I. M., Plutenko, M. O., Fritsky, I. O., & Derkach, S. S. (2018). Vyznachennja parametriv gostroi toksychnosti ferumu (IV) na bilyh myshah [Determination of the accumulative toxicity parameters of iron (IV) on white mice]. Ukrainian Journal of Ecology, 8 (2), 308–312. doi.org/10.15421/2018_343 [in Ukrainian].
16. Dukhnitsky, V. B., Derkach, I. M., Derkach, S. S., Fritsky, I.O., & Plutenko, M. O. (2019). Khronichna toksychnist klatrokhelatu Ferumu (IV) dlia bilykh shchuriv [Chronic toxicity of the Iron (IV) clathrochelate complexes for white rats]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 21(95), 15–21. https://doi.org/10.32718/nvlvet9503 [in Ukrainian].
17. Dukhnitsky, V. B., Derkach, I. M., Plutenko, M. O., Fritsky, I. O., & Derkach, S. S. (2019). Cumulative properties of Iron(IV) clathrochelate in rats [Kumuliatyvni vlastvosti klatrokhelatu Ferumu (IV) dlia bilykh shchuriv]. Visnyk PDAA [Messenger PDAA], 2, 238–246. doi: 10.31210/visnyk2019.02.32 [in Ukrainian].
18. Dukhnitsky, V. B., Derkach, I. M., Plutenko, M. O., Fritsky, I. O., & Derkach, S. S. (2019). Acute toxicity of the iron clathrochelate complexes. Regulatory Mechanisms in Biosystems, 10(3), 276–279. https://doi.org/10.15421/021942
19. Dukhnitsky, V. B., Derkach, I. M., Derkach, S. S., Plutenko, M. O. & Fritsky, I. O. (2019). Influence of iron (IV) clathrochelate complex on quail blood parameters and weight characteristics. Ukrainian Journal of Ecology, 9 (3), 126–131. DOI: 10.15421/2019_719
20. Dukhnitsky, V. B., Derkach, I. M., Derkach, S. S., Fritsky, I. O., & Plutenko, M. O. (2020). Doslidzhennia podrazniuvalnoi dii ta alerhennykh vlastyvostei klatrokhelatu Ferumu(IV) [Investigations of the irritant effect and allergenic properties of Fermat's clatrochelate (IV)]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 22(97), 130–135. doi: 10.32718/nvlvet9721 [in Ukrainian].
21. Dukhnitsky, V. B., Derkach, I. M., Derkach, S. S., Fritsky, I. O., & Plutenko, M. O. (2020). Doslidzhennia protyanemichnoi dii klatrokhelatu Ferumu(IV) na porosiatakh [Study of the antianemic effect of iron (IV) clatrochelate on piglets]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 22(99), 107–115. doi: 10.32718/nvlvet9917 [in Ukrainian].
22. Dukhnitsky, V. B., Kalachniuk L. H., Derkach, I. M., Derkach, S. S., Plutenko, M. O. & Fritsky, I. O. (2020). Iron(IV) hexahydrazide clathrochelate complexes: the chronic toxicity study. Ukrainian Journal of Ecology, 9 (3), 18–23. DOI: 10.15421/2020_3
23. Ganz, T. (2013). Systemic iron homeostasis. Physiological Reviews, 93 (4), 1721−1741. doi: 10.1152/physrev.00008
24. Gasanov, A. S., Amiov, D. R., Muhutdinova, D. M., Ovsjannikov, A. P., Churna, Z. G., & Shamsutdinova, N. V. (2020). Anemija i preparaty, primenjaemye pri ee lechenii i profilaktike [Anemia and drugs used in its treatment and prevention]. Kazan' [in Russian].
25. Gurevichev P. A., Del'cov A. A., & Urazaev D. N. (2007). Iron dextran preparations in veterinary medicine [Zhelezodekstranovye preparaty v veterinarii]. Materialy pervogo s"ezda veterinarnyh farmakologov Rossii [Proceedings of the first congress of veterinary pharmacologists of Russia]. Materialy s"ezda. Voronezh, 699 [in Russian].
26. Kang, J. O. (2001). Chronic iron overload and toxicity: clinical chemistry perspective. Clinical Laboratory Science Journal, 14 (3), 209-219.
27. Hrytsulia, M. (2020). Tseruloplazmin: praktychni aspekty zastosuvannia dlia pryskorenoho vidnovlennia patsiientiv khirurhichnoho profiliu [Ceruloplasmin: practical aspects of application for accelerated recovery of patients with a surgical profile]. Khirurhiia, Ortopediia, Travmatolohiia, Intensyvna terapiia [Surgery, Orthopedics, Traumatology, Intensive Care], 1, 39 [in Ukrainian].
28. Karput', I. M., & Nikoladze, M. G. (2001). Diagnostika i profilaktika alimentarnoj anemii porosjat [Diagnosis and prevention of alimentary anemia of piglets]. Veterinarija [Veterinary medicine], 4, 34−37 [in Russian].
29. Karput' I. M., & Nikoladze M. G. (2003). Obmen zheleza u zdorovyh i bol'nyh alimentarnoj anemiej porosjat [Iron metabolism in healthy and sick piglets with alimentary anemia]. Bulletin of the Academy of Agrarian Sciences of the Republic of Belarus [Izvestiya Akademii Agrarian Sciences of the Republic of Belarus], 4, 34−37 [in Russian].
30. Kogan, A. H., Ershov, V. I., & Alekperova, G. R. (1991). Costojanie svobodnoradikal'nyh processov pri zhelezodeficitnyh anemijah [The state of free radical processes in iron deficiency anemia]. Terapevticheskij arhiv [Therapeutic archive], 63, 7, 85–88.
31. Latour, I., Pregaldien, P., & Buc-Calderon (1992). Cell death and Lipid peroxidation in isolated hepatocytes incubated in the presence of hydrogen peroxide and iron salts. Archives of Toxicology, 66, 743–749.
32. Lytvynenko, O., Kaban, O., Hunina, L., Sorokin, B., Yehorov, I., Zhukov, Yu., Leshchuk, L., & Lytvynenko O. (2005). Zastosuvannia tseruloplazminu dlia profilaktyky uskladnen kompleksnoho likuvannia khvorykh onkolohichnoho profiliu [The use of ceruloplasmin for the prevention of complications of complex treatment of cancer patients]. Ukrainskyi khimioterapevtychnyi zhurnal [Ukrainian Chemotherapeutic Journal], 1–2, 69–72 [in Ukrainian].
33. Michael, A., & Johnny, L. (2015). Ceruloplasmin and Hypoferremia: Studies in Burn and Non-Burn Trauma Patients. Antioxidants 4, 153–169; doi:10.3390/antiox4010153.
34. Roxana, L., Dino S., Mircea, A., Catherine, V., Florence, D., François, B., Véronique M., Réginald, N., & Luc, R. (1998). Direct evidence of caeruloplasmin antioxidant properties. Molecular and Cellular Biochemistry, 189, 127–135. https://doi.org/10.1023/A:1006945713860
35. Sidorkin, V., Gavrish, V., Egunova, A., & Ubiraev, V. (2007). Bolezni svinej. [Diseases of swine]. Akvarium – print, Moskwa [in Russian].
36. Snitynskyi, V. V., Danchuk, V. V., & Buchko, O. M. (1998). Aktyvnist antyoksydantnykh fermentiv ta in-tensyvnist protsesiv vilnoradykalnoho okyslennia u tkanynakh svynei u period postnatalnoi adaptatsii [Activity of anti-oxidant enzymes and intensity of free-radical processes oxidation in pig tissues during post-natal adaptation]. Ukrainskyi biokhimichnyi zhurnal [Ukrainian Biochemical Journal], 70, 105–110 [in Ukrainian].
37. Svoboda, M., & Drabek, J. (2005). Iron deficiency in suckling piglets: etiology, clinical aspects and diagnosis. Folia Veterinaria.;49:104–111.
38. Tokarchuk, T. S. (2018). Pokaznyky antyoksydantnoho statusu v syrovattsi krovi porosiat za vykorystannia vitaminu E i tsytrativ Zn, Fe ta Ge [Indicators of antioxidant status in the serum of piglets using vitamin E and citrates Zn, Fe and Ge]. Tekhnolohiia vyrobnytstva i pererobky produktsii tvarynnytstva [Technology of production and processing of livestock products], 1, 7–83 [in Ukrainian].
39. Tomyn, S., Shylin, S. I., Bykov, D., Ksenofontov, V., Gumienna-Kontecka, E., Bon, V. & Fritsky, I.O. (2017) Indefinitely stable iron (IV) cage complexes formed in water by air oxidation. Nature Communications, 8, 1−8.
40. Vashhenko, V. I., & Vashhenko, T. N. (2008). Biologija i farmakologija ceruloplazmina: ot jeksperimenta do lekarstvennoj terapii [Biology and pharmacology of ceruloplasmin: from experiment to drug therapy]. Obzory po klinicheskoj farmakologii i lekarstvennoj terapii. Voenno-medicinskaja akademija im. S.M. Kirova, S. Peterburg, T. 6 [in Russian].
41. Wilkinson, J., Di X., Schönig, K., Buss, J., Kock, N., Cline, M., Saunders, T., Bujard, H., Torti, S., & Torti, F. (2006). Tissue-specific expression of ferritin H regulates cellular iron homoeostasis in vivo. Biochemical Journal. 395(3), 501–507. doi: https://doi.org/10.1042/BJ20060063
2. Antipov, A. A., Del'cov, A. A., Sodboev, C. C., & ZHarov A. V. (2011). Rol' svobodnoradikal'nogo okisleniya v patogeneze zhelezodificitnoj anemii i ee farmakokorrekcii [The role of free radical oxidation in the pathogenesis of iron deficiency anemia and its pharmacological correction]. MGAVMiB – MVA imeni K. I. Skryabina. Moskva,15–19 [in Russian].
3. Antipov, A. A, & Zharov A. V. (2013). Histological and morphometric changes in the liver, kidneys, spleen and lymph nodes of piglets with alimentary iron deficiency anemia [Gistologicheskie i morfometricheskie izmeneniya pecheni, pochek, selezenki i limfaticheskih uzlov porosyat pri alimentarnoj zhelezodeficitnoj anemii]. Rossijskij veterinarnyj zhurnal. Sel'skohozyajstvennye zhivotnye [Russian veterinary journal. Farm animals], 1, 19–21 [in Russian].
4. Antonyak, G. L., Solohub, L. I., Snitynskyi, V. V., & Babych, N. O. (2006). Zalizo v orhanizmi lyudyny I tvaryn (biohimichni, imunolohichni ta ekolohichni aspekty) [Iron in humans and animals (biochemical, immunological and environmental aspects)]. Lviv [in Ukrainian].
5. Bahramov, S. M., Kazakbaev, H. M., & Buglanov, A. A. (2014). Transferrin: rol' v obmene zheleza i nekotorye aspekty [Transferrin: role in iron metabolism and some aspects]. Gematologija i transfuziologija [Hematology and transfusiology], 2, 39−42 [in Russian].
6. Belousova Y. B., Kukesa V. G., Lepahina V. K., & Petrova V. I. (Eds.) (2014). Clinical pharmacology: a national guide [Klinicheskaya farmakologiya: nacional'noe rukovodstvo]. Moskwa, Geotar-Media [in Russian].
7. Bonkovsky, S., & Herbert, L. (1991). Iron and the liver. The American journal of the medical sciences, 301(1), 32−43. doi.org/10.1097/00000441-199101000-00006
8. Buchko, O. M., Snitynskyi, V. V., Danchuk, V. V., & Antoniak H. L. (1998). Zastosuvanna spoluk selenu dlia profilaktyky oksydatsiinoho stresu u porosiat rannoho viku [The use of selenium compounds for the prevention of oxidative stress in early piglets of his age]. Haukovyi visnyk Hatsionalnoho Ahrarnoho universytetu [Scientific Bulletin of the National Agrarian University], 10, 156–163 [in Ukrainian].
9. Chen, J., Anderson., J., DeWeese-Scott, C., Fedorova, N., Geer, L., He, S., Hurwitz, D., Jackson, J., Jacobs, A., Lanczycki, Ch., Liebert, C., Liu, Ch., Madej, T., Marchler-Bauer, A., Marchler, G., Mazumder, R., Nikolskaya, A., Rao, B., Panchenko, A., Shoemaker, A., Simonyan, V., Song, J., Thiessen, P., Vasudevan, S., Wang, Y., Yamashita, R., Yin, J., Bryant, S. (2003). MMDB: Entrez's 3D-structure database, Nucleic Acids Research, 31, 1, 474–477, https://doi.org/10.1093/nar/gkg086
10. Danchuk, O. V. (2013). Peroksydne okysnennia lipidiv ta aktyvnist systemy antyoksydantnoho zakhystu u porosiatsysuniv pid vplyvom preparativ zaliza [Peroxidation of lipids and the activity of the antioxidant defense system in suckling piglets under the influence of iron preparations]. Svynarstvo [Swine breeding], 62, 89–93 [in Ukrainian].
11. Del'cov, A. A. Antipov, A.A. (2013). Morphological changes in the liver and kidneys of piglets with iron deficiency anemia [Morfologicheskie izmeneniya pecheni i pochek porosyat pri zhelezodeficitnoj anemii]. Veterinary [Veterinariya], 4, 46–49
12. Del'cov, A. A., Gurevichev, P.A. (2007). Study of toxicity parameters of new iron-dextran preparations [Izuchenie parametrov toksichnosti novyh zhelezodekstranovyh preparatov]. Materials of the II All-Russian Scientific and Practical Conference of Young Scientists "Youth and Science of the XXI Century" [Materialy II Otkrytoj Vserossijskoj nauchnoprakticheskoj konferencii molodyh uchenyh «Molodezh' i nauka XXI veka»]. Ul'yanovsk, 57–61.
13. Dorozhkin, V. I. (1996). Rezul'taty issledovanij biologicheskoj aktivnosti metionata medi [The results of research on the biological activity of media methonates]. Materialy nauchnoj konferencii, posvjashhennye 50-letiju Krasnodarskoj AIVS «Sostojanie i perspektivy razvitija nauchnyh issledovanij po profilaktike i lecheniju sel'skohozjajstvennyh zhivotnyh i ptic». Krasnodar, 91–92 [in Russian].
14. Droge, W., (2001). Free radicals in the physiological control of cell ruction. Physiological reviews, 82. 47–95.
15. Dukhnitsky, V. B., Derkach, I. M., Plutenko, M. O., Fritsky, I. O., & Derkach, S. S. (2018). Vyznachennja parametriv gostroi toksychnosti ferumu (IV) na bilyh myshah [Determination of the accumulative toxicity parameters of iron (IV) on white mice]. Ukrainian Journal of Ecology, 8 (2), 308–312. doi.org/10.15421/2018_343 [in Ukrainian].
16. Dukhnitsky, V. B., Derkach, I. M., Derkach, S. S., Fritsky, I.O., & Plutenko, M. O. (2019). Khronichna toksychnist klatrokhelatu Ferumu (IV) dlia bilykh shchuriv [Chronic toxicity of the Iron (IV) clathrochelate complexes for white rats]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 21(95), 15–21. https://doi.org/10.32718/nvlvet9503 [in Ukrainian].
17. Dukhnitsky, V. B., Derkach, I. M., Plutenko, M. O., Fritsky, I. O., & Derkach, S. S. (2019). Cumulative properties of Iron(IV) clathrochelate in rats [Kumuliatyvni vlastvosti klatrokhelatu Ferumu (IV) dlia bilykh shchuriv]. Visnyk PDAA [Messenger PDAA], 2, 238–246. doi: 10.31210/visnyk2019.02.32 [in Ukrainian].
18. Dukhnitsky, V. B., Derkach, I. M., Plutenko, M. O., Fritsky, I. O., & Derkach, S. S. (2019). Acute toxicity of the iron clathrochelate complexes. Regulatory Mechanisms in Biosystems, 10(3), 276–279. https://doi.org/10.15421/021942
19. Dukhnitsky, V. B., Derkach, I. M., Derkach, S. S., Plutenko, M. O. & Fritsky, I. O. (2019). Influence of iron (IV) clathrochelate complex on quail blood parameters and weight characteristics. Ukrainian Journal of Ecology, 9 (3), 126–131. DOI: 10.15421/2019_719
20. Dukhnitsky, V. B., Derkach, I. M., Derkach, S. S., Fritsky, I. O., & Plutenko, M. O. (2020). Doslidzhennia podrazniuvalnoi dii ta alerhennykh vlastyvostei klatrokhelatu Ferumu(IV) [Investigations of the irritant effect and allergenic properties of Fermat's clatrochelate (IV)]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 22(97), 130–135. doi: 10.32718/nvlvet9721 [in Ukrainian].
21. Dukhnitsky, V. B., Derkach, I. M., Derkach, S. S., Fritsky, I. O., & Plutenko, M. O. (2020). Doslidzhennia protyanemichnoi dii klatrokhelatu Ferumu(IV) na porosiatakh [Study of the antianemic effect of iron (IV) clatrochelate on piglets]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 22(99), 107–115. doi: 10.32718/nvlvet9917 [in Ukrainian].
22. Dukhnitsky, V. B., Kalachniuk L. H., Derkach, I. M., Derkach, S. S., Plutenko, M. O. & Fritsky, I. O. (2020). Iron(IV) hexahydrazide clathrochelate complexes: the chronic toxicity study. Ukrainian Journal of Ecology, 9 (3), 18–23. DOI: 10.15421/2020_3
23. Ganz, T. (2013). Systemic iron homeostasis. Physiological Reviews, 93 (4), 1721−1741. doi: 10.1152/physrev.00008
24. Gasanov, A. S., Amiov, D. R., Muhutdinova, D. M., Ovsjannikov, A. P., Churna, Z. G., & Shamsutdinova, N. V. (2020). Anemija i preparaty, primenjaemye pri ee lechenii i profilaktike [Anemia and drugs used in its treatment and prevention]. Kazan' [in Russian].
25. Gurevichev P. A., Del'cov A. A., & Urazaev D. N. (2007). Iron dextran preparations in veterinary medicine [Zhelezodekstranovye preparaty v veterinarii]. Materialy pervogo s"ezda veterinarnyh farmakologov Rossii [Proceedings of the first congress of veterinary pharmacologists of Russia]. Materialy s"ezda. Voronezh, 699 [in Russian].
26. Kang, J. O. (2001). Chronic iron overload and toxicity: clinical chemistry perspective. Clinical Laboratory Science Journal, 14 (3), 209-219.
27. Hrytsulia, M. (2020). Tseruloplazmin: praktychni aspekty zastosuvannia dlia pryskorenoho vidnovlennia patsiientiv khirurhichnoho profiliu [Ceruloplasmin: practical aspects of application for accelerated recovery of patients with a surgical profile]. Khirurhiia, Ortopediia, Travmatolohiia, Intensyvna terapiia [Surgery, Orthopedics, Traumatology, Intensive Care], 1, 39 [in Ukrainian].
28. Karput', I. M., & Nikoladze, M. G. (2001). Diagnostika i profilaktika alimentarnoj anemii porosjat [Diagnosis and prevention of alimentary anemia of piglets]. Veterinarija [Veterinary medicine], 4, 34−37 [in Russian].
29. Karput' I. M., & Nikoladze M. G. (2003). Obmen zheleza u zdorovyh i bol'nyh alimentarnoj anemiej porosjat [Iron metabolism in healthy and sick piglets with alimentary anemia]. Bulletin of the Academy of Agrarian Sciences of the Republic of Belarus [Izvestiya Akademii Agrarian Sciences of the Republic of Belarus], 4, 34−37 [in Russian].
30. Kogan, A. H., Ershov, V. I., & Alekperova, G. R. (1991). Costojanie svobodnoradikal'nyh processov pri zhelezodeficitnyh anemijah [The state of free radical processes in iron deficiency anemia]. Terapevticheskij arhiv [Therapeutic archive], 63, 7, 85–88.
31. Latour, I., Pregaldien, P., & Buc-Calderon (1992). Cell death and Lipid peroxidation in isolated hepatocytes incubated in the presence of hydrogen peroxide and iron salts. Archives of Toxicology, 66, 743–749.
32. Lytvynenko, O., Kaban, O., Hunina, L., Sorokin, B., Yehorov, I., Zhukov, Yu., Leshchuk, L., & Lytvynenko O. (2005). Zastosuvannia tseruloplazminu dlia profilaktyky uskladnen kompleksnoho likuvannia khvorykh onkolohichnoho profiliu [The use of ceruloplasmin for the prevention of complications of complex treatment of cancer patients]. Ukrainskyi khimioterapevtychnyi zhurnal [Ukrainian Chemotherapeutic Journal], 1–2, 69–72 [in Ukrainian].
33. Michael, A., & Johnny, L. (2015). Ceruloplasmin and Hypoferremia: Studies in Burn and Non-Burn Trauma Patients. Antioxidants 4, 153–169; doi:10.3390/antiox4010153.
34. Roxana, L., Dino S., Mircea, A., Catherine, V., Florence, D., François, B., Véronique M., Réginald, N., & Luc, R. (1998). Direct evidence of caeruloplasmin antioxidant properties. Molecular and Cellular Biochemistry, 189, 127–135. https://doi.org/10.1023/A:1006945713860
35. Sidorkin, V., Gavrish, V., Egunova, A., & Ubiraev, V. (2007). Bolezni svinej. [Diseases of swine]. Akvarium – print, Moskwa [in Russian].
36. Snitynskyi, V. V., Danchuk, V. V., & Buchko, O. M. (1998). Aktyvnist antyoksydantnykh fermentiv ta in-tensyvnist protsesiv vilnoradykalnoho okyslennia u tkanynakh svynei u period postnatalnoi adaptatsii [Activity of anti-oxidant enzymes and intensity of free-radical processes oxidation in pig tissues during post-natal adaptation]. Ukrainskyi biokhimichnyi zhurnal [Ukrainian Biochemical Journal], 70, 105–110 [in Ukrainian].
37. Svoboda, M., & Drabek, J. (2005). Iron deficiency in suckling piglets: etiology, clinical aspects and diagnosis. Folia Veterinaria.;49:104–111.
38. Tokarchuk, T. S. (2018). Pokaznyky antyoksydantnoho statusu v syrovattsi krovi porosiat za vykorystannia vitaminu E i tsytrativ Zn, Fe ta Ge [Indicators of antioxidant status in the serum of piglets using vitamin E and citrates Zn, Fe and Ge]. Tekhnolohiia vyrobnytstva i pererobky produktsii tvarynnytstva [Technology of production and processing of livestock products], 1, 7–83 [in Ukrainian].
39. Tomyn, S., Shylin, S. I., Bykov, D., Ksenofontov, V., Gumienna-Kontecka, E., Bon, V. & Fritsky, I.O. (2017) Indefinitely stable iron (IV) cage complexes formed in water by air oxidation. Nature Communications, 8, 1−8.
40. Vashhenko, V. I., & Vashhenko, T. N. (2008). Biologija i farmakologija ceruloplazmina: ot jeksperimenta do lekarstvennoj terapii [Biology and pharmacology of ceruloplasmin: from experiment to drug therapy]. Obzory po klinicheskoj farmakologii i lekarstvennoj terapii. Voenno-medicinskaja akademija im. S.M. Kirova, S. Peterburg, T. 6 [in Russian].
41. Wilkinson, J., Di X., Schönig, K., Buss, J., Kock, N., Cline, M., Saunders, T., Bujard, H., Torti, S., & Torti, F. (2006). Tissue-specific expression of ferritin H regulates cellular iron homoeostasis in vivo. Biochemical Journal. 395(3), 501–507. doi: https://doi.org/10.1042/BJ20060063
Опубліковано
2022-01-27
Як цитувати
Деркач, І. М., Духницький, В. Б., Деркач, С. С., Фрицький, О. І., Плутенко, М. О., & Лозовий, В. М. (2022). ВПЛИВ КЛАТРОХЕЛАТУ ФЕРУМУ(IV) НА ВМІСТ ЦЕРУЛОПЛАЗМІНУ В СИРОВАТЦІ КРОВІ ПОРОСЯТ. Вісник Сумського національного аграрного університету. Серія: Ветеринарна медицина, (2 (53), 26-32. https://doi.org/10.32845/bsnau.vet.2021.2.4
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