DETERMINATION OF EFFICIENCY THE VETERINARY PREPARATION "WORMICIL PASTE" FOR HELMINTH INVASION IN CARNIVORS
Abstract
Clinical trials of the veterinary drug "WORMIKIL paste" manufactured by "Ukrzoovetprompostach" LLC, str. Kavkazka, 1, p. Plakhtyanka, Buchansky district, Kyiv region, Ukraine, for the treatment of carnivores, for infestations caused by Toxocara canis, Toxocara cati, Toxascaris leonina, Trichuris vulpis, Uncinaria stenocephala, Passalurus ambiguus, Trichostrongylus retortaeformis, Paraspidodera uncinata, Trichosomoides crassicauda, Strongyloides. ratti, Dipylidium caninum, Taenia esp. The helminthicidal effect of the veterinary drug "WORMIKIL paste" in the manufacturer's recommended doses, multiplicity and method of application was studied. Experimental studies have proven a wide range of anthelmintic action of the drug "WORMIKIL paste" in case of nematodes and cestodes infestation of carnivorous animals. Before the deworming, a clinical examination and individual weighing of the animals of the experimental group were carried out, the amount of the drug "WORMIKIL paste" was calculated for each animal. Deworming was carried out before morning feeding by administering the drug "WORMIKIL paste" orally, in a dose of 1 ml (dogs, cats) and 0.5 ml (rabbits, rats) per 1 kg of the animal's body weight. After three days, according to the instructions on the leaflet, deworming was repeated for therapeutic purposes. After using the veterinary drug "WORMIKIL paste", according to the manufacturer's recommendations, the extent and intensity of the drug was determined on the seventh and fourteenth day after deworming. Clinical studies have shown that the veterinary drug "WORMIKIL paste" has shown high effectiveness against helminthic infestation in dogs, cats, rabbits and rats, the causative agents of which are Toxocara canis, Toxocara cati, Toxascaris leonina, Trichuris vulpis, Uncinaria stenocephala, Passalurus ambiguus, Trichostrongylus retortaeformis, Paraspidodera uncinata, Trichosomoides crassicauda, Strongyloides ratti, Dipylidium caninum, Taeniae spp. The drug did not cause adverse reactions and toxic effects on the animal body, the extensivity and intensity of the drug "WORMICIL paste" against nematodes and cestodes of carnivorous animals fourteen days after application was 100%. The veterinary drug "WORMIKIL paste" is recommended for use in the practice of veterinary medicine.
References
2. Anderson, R. C., Chabaud, A. G. & Willmott, S. (2019). Keys to the Nematode Parasites of Vertebrates, Archival Volume. CABI, Wallingford, 1-424.https://doi.org/10.1079/9781845935726.0000
3. Bonilla-Aldana DK, Morales-Garcia LV, Ulloque Badaracco JR, Mosquera-Rojas MD, Alarcón-Braga EA, Hernandez-Bustamante EA, Al-Kassab-Córdova A, Benites-Zapata VA, Rodriguez-Morales AJ, Delgado O. (2023). Prevalence of Toxocara eggs in Latin American parks: a systematic review and meta-analysis. .Infez Med. Sep 1;31(3):329-349. doi: 10.53854/liim-3103-7.
4. Bonilla-Aldana JL, Espinosa-Nuñez AC, Bonilla-Aldana DK, Rodriguez-Morales AJ. (2024). Toxocara cati Infection in Cats (Felis catus): A Systematic Review and Meta-Analysis. Animals (Basel). Mar 27;14(7):1022. doi: 10.3390/ani14071022.
5. Bourgoin G., Callait-Cardinal M.P., Bouhsira E., Polack B., Bourdeau P., Roussel Ariza C., Carassou L., Lienard E., Drake J. (2022). Prevalence of major digestive and respiratory helminths in dogs and cats in France: Results of a multicenter study. Parasit. Vectors. 15:314. doi: 10.1186/s13071-022-05368-7.
6. Chen J, Zhou DH, Nisbet AJ, Xu MJ, Huang SY, Li MW, Wang CR, Zhu XQ. (2012). Advances in molecular identification, taxonomy, genetic variation and diagnosis of Toxocara spp. Infect Genet Evol. Oct;12(7):1344-8. doi: 10.1016/j.meegid.2012.04.019.
7. Cross A.R., Baldwin V.M., Roy S., Essex-Lopresti A.E., Prior J.L., Harmer N.J. (2019). Zoonoses under our noses. Microbes Infect. 21:10–19. doi: 10.1016/j.micinf.2018.06.001.
8. Eslahi AV, Badri M, Khorshidi A, Majidiani H, Hooshmand E, Hosseini H, Taghipour A, Foroutan M, Pestehchian N, Firoozeh F, Riahi SM, Zibaei M. (2020). Prevalence of Toxocara and Toxascaris infection among human and animals in Iran with meta-analysis approach. BMC Infect Dis. Jan 7;20(1):20. doi: 10.1186/s12879-020-4759-8.
9. Fan CK, Liao CW, Cheng YC. (2013). Factors affecting disease manifestation of toxocarosis in humans: genetics and environment. Vet Parasitol. Apr 15;193(4):342-52. doi: 10.1016/j.vetpar.2012.12.030.
10. Holland C.V. (2017). Knowledge gaps in the epidemiology of Toxocara: The enigma remains. Parasitology. 144:81–94. doi: 10.1017/S0031182015001407.
11. Idikaa, I. K., Onuoraha, E. C., Obia, C. F., Umeakuanac, P. U., Nwosua, C. O., Onaha, D. N. & Chiejina, S. N. (2017). Prevalence of gastrointestinal helminth infections of dog in Enugu State, South Eastern Nigeria. Parasite Epidemiol. Control., 2, 97-104. https://doi.org/10.1016/j.parepi.2017.05.004
12. Iturbe Cossío TL, Montes Luna AD, Ruiz Mejia M, Flores Ortega A, Heredia Cárdenas R, Romero Núñez C. J (2021).Risk factors associated with cat parasites in a feline medical center. FMS Open Rep. Aug 18;7(2) doi: 10.1177/20551169211033183.
13. Jenkins EJ. (2020). Toxocara spp. in dogs and cats in Canada Adv Parasitol. 109:641-653. doi: 10.1016/bs.apar.2020.01.026.
14. Kalyanasundaram A., Henry C., Brym M.Z., Kendall R.J. (2018). Molecular identification of Physaloptera sp. from wild northern bobwhite (Colinus virginianus) in the Rolling Plains ecoregion of Texas. Parasitol. Res. 117:2963–2969. doi: 10.1007/s00436-018-5993-5.
15. Lima JCMP, Piero FD. (2021) Severe concomitant Physaloptera sp., Dirofilaria immitis, Toxocara cati, Dipylidium caninum, Ancylostoma sp. and Taenia taeniaeformis infection in a cat. Pathogens. 10:109. DOI: 10.3390/pathogens10020109
16. Little S, Adolph C, Downie K, Snider T, Reichard M. (2015). High Prevalence of Covert Infection With Gastrointestinal Helminths in Cats. Am Anim Hosp Assoc. Nov-Dec;51(6):359-64. doi: 10.5326/JAAHA-MS-6221.
17. Macpherson, C. N. L. & Torgerson, P. R. (2013). Dogs and Cestode Zoonoses. In: Dogs, Zoonoses and Public Health. CABI: UK-USA, 127-152. https://doi.org/10.1079/9781845938352.0127
18. Mendoza-Roldan JA, Modry D, Otranto D.(2020). Zoonotic parasites of reptiles: a crawling threat. Trends Parasitol. 36:677–687. doi: 10.1016/j.pt.2020.04.014
19. Nagamori Y., Payton M.E., Duncan-Decocq R., Johnson E.M. (2018). Fecal survey of parasites in free-roaming cats in northcentral Oklahoma, United States. Vet. Parasitol. Reg. Stud. Rep.14:50–53. doi: 10.1016/j.vprsr.2018.08.008.
20. Omonijo AO, Kalinda C, Mukaratirwa S. (2019). A systematic review and meta-analysis of canine, feline and human Toxocara infections in sub-Saharan Africa. J Helminthol. Nov 4;94:e96. doi: 10.1017/S0022149X19000889.
21. Quintero-Cusguen P., Gutiérrez-Álvarez A.M., Patiño D.R. (2021). Toxocariosis. Acta Neurol. Colomb. 37:169–173. doi: 10.22379/24224022350.
22. Rodriguez-Morales A.J., González-Leal N., Montes-Montoya M.C., Fernández-Espíndola L., Bonilla-Aldana D.K., Azeñas-Burgoa J.M., de Medina J.C.D., Rotela-Fisch V., Bermudez-Calderon M., Arteaga-Livias K., et al. (2021). Cutaneous Larva Migrans. Curr. Trop. Med. Rep. 8:190–203. doi: 10.1007/s40475-021-00239-0.
23. Rubel, D., Zunino, G., Santillán, G. & Wisnivesky, C. (2013). Epidemiology of Toxocara canis in the dog population from two areas of different socioeconomic status, Greater Buenos Aires, Argentina. Veterinary Parasitology, 115, 275–286. http://dx.doi.org/10.1016/S0304-4017(03)00185-7
24. Safarov, A., Mihalca, A. D., Park, G.-M., Akramova, F., Ionic ̆a, A. M., Abdinabiev, O., Deak, G. & Azimov, D. A. (2022). Survey of Helminths of Dogs in Rural and Urban Areas of Uzbekistan and the Zoonotic Risk to Human Population. Pathogens, 11, 1085.https://doi.org/10.3390/pathogens11101085
25. Silva WI, Lima EF, Silva JO, Alves MM, Alves CLP, Silva ALP, Lima JA, Feitosa TF, (2023) Endoparasites in domestic cats (Felis catus) in the semi-arid region of Northeast Brazil. Rev Bras Parasitol Vet. Nov 27;32(4):e012123. doi: 10.1590/S1984-29612023065.
26. Symeonidou I, Gelasakis AI, Arsenopoulos K, Angelou A, Beugnet F, Papadopoulos E. (2018). Feline gastrointestinal parasitism in Greece: emergent zoonotic species and associated risk factors Parasit Vectors. Apr 4;11(1):227. doi: 10.1186/s13071-018-2812-x.
27. Villeneuve A., Polley L., Jenkins E., Schurer J., Gilleard J., Kutz S., Conboy G., Benoit D., Seewald W., Gagné F. (2015). Parasite prevalence in fecal samples from shelter dogs and cats across the Canadian provinces. Parasites Vectors. 8:1–10. doi: 10.1186/s13071-015-0870-x.
28. Waal T, Aungier S, Lawlor A, Goddu T, Jones M, Szlosek D. (2022). Retrospective Survey of Dog and Cat Endoparasites in Ireland: Antigen Detection. Animals (Basel). Dec 29;13(1):137. doi: 10.3390/ani13010137
29. Wolfe AK, Bateman PW, Fleming PA. (2018). Does urbanization influence the diet of a large snake. Curr Zool. 64:311–318. doi: 10.1093/cz/zox039.
30. Wyrosdick H.M., Chapman A., Martinez J., Schaefer J.J.(2017). Parasite prevalence survey in shelter cats in Citrus County, Florida. Vet. Parasitol. Reg. Stud. Rep.10:20–24. doi: 10.1016/j.vprsr.2017.07.002.
ISSN 
ISSN 
