THE EFFECT OF A COMBINED CHANGE OF SOME INDICATORS OF HOMEOSTASIS ON THE REPRODUCTIVE FUNCTION OF COWS
Keywords:
cows, transit period, infertility, reproduction, protein and vitamin metabolism
Abstract
The progressive development of the livestock industry in Ukraine is based on several basic principles, one of which is reproduction. Effective reproduction of the main herd is a guarantee of sustainable development of each individual animal husbandry and the industry as a whole. With a constant number of livestock in the farm, repairs make up about 25%, and with increasing livestock – from 30% to 40%. A fairly wide range of reasons for the decrease, and sometimes even the complete cessation of the reproductive capacity of cows, is known. To establish specific causes, it is important to develop effective methods of forecasting and diagnosis of gynecological pathologies of cows, especially in the transit period. The purpose of the study was to investigate the correlation between the change in individual biochemical indicators of the blood of cows 30‒60 days after calving and the reproductive capacity of females. The research was carried out during 2021-2023 in farms of the Sumy region with a non-attached type of maintenance. Productivity was at the level of 7200‒7500. Blood for biochemical studies was collected from the subcaudal vein between 30 and 60 days after calving. Subsequently, biochemical studies were carried out according to generally accepted methods. The obtained digital material was processed by methods of variational statistics using SPSS Data editor 17.0 version. A tense protein metabolism in cows in the postpartum period was established, which was characterized by the upper limit of the total protein level – 86.0±2.58 g/l and the protein coefficient – 0.76±0.037 units. A decrease in the level of globules by 1.2 times was recorded in infertile cows, which was accompanied by a decrease in the protein coefficient by 1.24 times. Infertile cows were characterized by an increase in asparataminotransferase and alkaline phosphatase by 1.37 (р≤0.01) and 1.17 times (р≤0.05), respectively. However, in the cows of the first group (fertile animals), a trend of an increase in the de Ritis coefficient by 1.29 times and a decrease in the blood urea nitrogen level by 1.19 times was registered compared to infertile cows. An important prognostic criterion is a 1.13 times higher level of vitamin E (12.8%) in fertile cows. Hypocalcemia and hyperphosphoremia were diagnosed in the blood of infertile cows with a clearance of 1.18 times that of healthy cows (р≤0.05), which caused a tendency to decrease the Ca/P ratio. Changes in biochemical indicators in the blood of animals of both subgroups of all other micro- and macrominerals probably did not differ, with the exception of zinc, the level of which was 1.3 times higher in the blood of infertile animals (р≤0.05).
References
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21. Hussein, H.A., Staufenbiel, R. (2012). Variations in Copper Concentration and Ceruloplasmin Activity of Dairy Cows in Relation to Lactation Stages with Regard to Ceruloplasmin to Copper Ratios. Biol Trace Elem Res, 146, 47–52. https://doi.org/10.1007/s12011-011-9226-3
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24. Little, M. W., O'Connell, N. E., & Ferris, C. P. (2016). A comparison of individual cow versus group concentrate allocation strategies on dry matter intake, milk production, tissue changes, and fertility of Holstein-Friesian cows offered a grass silage diet. Journal of dairy science, 99(6), 4360–4373. https://doi.org/10.3168/jds.2015-10441
25. Liu, J., Cook, R., Danhof, L., Lopatto, D., Stoltzfus, J. R., & Benning, C. (2021). Connecting research and teaching introductory cell and molecular biology using an Arabidopsis mutant screen. Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology, 49(6), 926–934. https:// ьdoi.org/10.1002/bmb.21579
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30. Raboisson, Didier & Albaaj, Ahmad & Nonne, G. & Foucras, Gilles. (2017). High urea and pregnancy or conception in dairy cows: A meta-analysis to define the appropriate urea threshold. Journal of Dairy Science. 100. https://doi.org/10.3168/jds.2016-12009.
31. Schimmel, P., Kleinjans, L., Bongers, R. S., Knol, J., & Belzer, C. (2021). Breast milk urea as a nitrogen source for urease positive Bifidobacterium infantis. FEMS microbiology ecology, 97(3), fiab019. https://doi.org/10.1093/femsec/fiab019
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34. Vailati-Riboni, M., Osorio, J. S., Trevisi, E., Luchini, D., & Loor, J. J. (2017). Supplemental Smartamine M in higherenergy diets during the prepartal period improves hepatic biomarkers of health and oxidative status in Holstein cows. Journal of animal science and biotechnology, 8, 17. https://doi.org/10.1186/s40104-017-0147-7
35. Yerra, Veera Ganesh & Drosatos, Konstantinos. (2023). Specificity Proteins (SP) and Krüppel-like Factors (KLF) in Liver Physiology and Pathology. International Journal of Molecular Sciences. 24. 4682. https://doi.org/10.3390/ijms24054682.
36. Zangeronimo, Marcio & Oberlender, Guilherme & Solis-Murgas, Luis. (2013). Effect of nutrition on the reproduction in gilts – a review. Revista Científica Eletrônica de Medicina Veterinária. XI. 1-20.
37. Zhao, C., Shu, S., Bai, Y., Wang, D., Xia, C., & Xu, C. (2019). Plasma Protein Comparison between Dairy Cows with Inactive Ovaries and Estrus. Scientific reports, 9(1), 13709. https://doi.org/10.1038/s41598-019-49785-8
2. Akhtar, Muhammad & Rahman, Hifzul & Pasha, Talat & Khan, Nauman & Chishti, Ghazanfar & Ali, Mubashar & Imran, Muhammad & Tahir, Muhammad & Naveed ul Haque, Muhammad. (2022). Effects of peripartal glucose precursor supplementation on lactation performance and metabolic health of primiparous and multiparous dairy cows. Animal
Bioscience. 36. https://doi.org/10.5713/ab.22.0218.
3. Atsushi Watanabe, Eiji Hata, Petr Sláma, Kazuhiro Kimura, Tsunao Hirai. (2018) Characteristics of mammary secretions from Holstein cows at approximately 10 days before parturition: with or without intramammary infection. Journal of Applied Animal Research 46:1, pages 604-608. https://doi.org/10.1080/09712119.2016.1256293
4. Balbaied, T., & Moore, E. (2019). Overview of Optical and Electrochemical Alkaline Phosphatase (ALP) Biosensors: Recent Approaches in Cells Culture Techniques. Biosensors, 9(3), 102. https://doi.org/10.3390/bios9030102
5. Bäumer, J. & Staufenbiel, R. (2019). Validation of an automated assay for measurement of bovine plasma ceruloplasmin. Acta Vet Scand 61, 34. https://doi.org/10.1186/s13028-019-0470-4
6. Bobbo, T., Fiore, E., Gianesella, M., Morgante, M., Gallo, L., Ruegg, P. L., Bittante, G., & Cecchinato, A. (2017). Variation in blood serum proteins and association with somatic cell count in dairy cattle from multi-breed herds. Animal : an international journal of animal bioscience, 11(12), 2309–2319. https://doi.org/10.1017/S1751731117001227
7. Boukhechem, S., Moula, N., Lakhdara, N., & Kaidi, R. (2019). Feeding practices of dairy cows in Algeria: Characterization, typology, and impact on milk production and fertility. Journal of advanced veterinary and animal research, 6(4), 567–574. https://doi.org/10.5455/javar.2019.f384
8. Bova, T. L., Chiavaccini, L., Cline, G. F., Hart, C. G., Matheny, K., Muth, A. M., Voelz, B. E., Kesler, D., & Memili, E. (2014). Environmental stressors influencing hormones and systems physiology in cattle. Reproductive biology and endocrinology : RB&E, 12, 58. https://doi.org/10.1186/1477-7827-12-58
9. Brahma, Biswajit & Ghosh, S. & Pankaj, Dr. Prabhat & Mandal, G.. (2011). Evaluation of Milk Urea Concentration as Useful Indicator for Dairy Herd Management: A Review. Asian Journal of Animal and Veterinary Advances. 1. 1-18. https://doi.org/10.3923/ajava.2011.1.19.
10. Chastant, S., & Saint-Dizier, M. (2019). Inflammation: friend or foe of bovine reproduction?.Animal reproduction,16(3), 539–547. https://doi.org/10.21451/1984-3143-AR2019-0057
11. Chen, Y. C., Yeh, Y. C., Lin, Y. F., Au, H. K., Hsia, S. M., Chen, Y. H., & Hsieh, R. H. (2022). Aspartame Consumption, Mitochondrial Disorder-Induced Impaired Ovarian Function, and Infertility Risk. International journal of molecular sciences, 23(21), 12740. https://doi.org/10.3390/ijms232112740
12. Cheng, Z., Oguejiofor, C. F., Swangchan-Uthai, T., Carr, S., & Wathes, D. C. (2015). Relationships between Circulating Urea Concentrations and Endometrial Function in Postpartum Dairy Cows. Animals : an open access journal from MDPI, 5(3), 748–773. https://doi.org/10.3390/ani5030382
13. Csilla, Tóthová & Pavol, Mudroň & Oskar, Nagy. (2017). The electrophoretic pattern of serum proteins in dairy cows with inflammatory diseases. Acta veterinaria. 67. 178-190. https://doi.org/10.1515/acve-2017-0016.
14. Cui, L., Wang, H., Ding, Y., Li, J., & Li, J. (2019). Changes in the blood routine, biochemical indexes and the pro-inflammatory cytokine expressions of peripheral leukocytes in postpartum dairy cows with metritis. BMC veterinary research, 15(1), 157. https://doi.org/10.1186/s12917-019-1912-y
15. Djokovic, Radojica & Cincovic, Marko & Ilić, Zoran & Kurćubić, Vladimir & Andjelic, Biljana & Petrovic, Milos & Lalic, Nebojsa & Jasovic, Boban. (2019). Estimation of Metabolic Status in High Yielding Dairy Cows During Transition Period and Full Lactation. Acta Scientiae Veterinariae. 47. 1667. https://doi.org/10.22456/1679-9216.92100.
16. Galán, E., Llonch, P., Villagrá, A., Levit, H., Pinto, S., & Del Prado, A. (2018). A systematic review of non-productivityrelated animal-based indicators of heat stress resilience in dairycattle. PloS one, 13(11), e0206520. https://doi.org/10.1371/journal.pone.0206520
17. Gammoh, Nour & Rink, Lothar. (2020). Zinc and the immune system: Insights into the role of zinc in autoimmune diseases. https://doi.org/10.1016/B978-0-12-805378-2.00003-6.
18. Gonçalves-de-Albuquerque, C. F., Barnese, M. R. C., Soares, M. A., Castro Faria, M. V., Silva, A. R., Castro Faria Neto, H. C., Burth, P., & Younes-Ibrahim, M. (2019). Serum albumin-fatty acid saturation test. MethodsX, 6, 1871–1875. https://doi.org/10.1016/j.mex.2019.08.004
19. Haga, S., Ishizaki, H., & Roh, S. (2021). The Physiological Roles of Vitamin E and Hypovitaminosis E in the Transition Period of High-Yielding Dairy Cows. Animals : an open access journal from MDPI, 11(4), 1088. https://doi.org/10.3390/ani11041088
20. Hussein, H.A., Bäumer, J. & Staufenbiel, R. Validation of an automated assay for measurement of bovine plasma ceruloplasmin. Acta Vet Scand, 61, 34 (2019). https://doi.org/10.1186/s13028-019-0470-4
21. Hussein, H.A., Staufenbiel, R. (2012). Variations in Copper Concentration and Ceruloplasmin Activity of Dairy Cows in Relation to Lactation Stages with Regard to Ceruloplasmin to Copper Ratios. Biol Trace Elem Res, 146, 47–52. https://doi.org/10.1007/s12011-011-9226-3
22. Kowsar, R., Iranshahi, V. N., Sadeghi, N., Riasi, A., & Miyamoto, A. (2018). Urea influences amino acid turnover in bovine cumulus-oocyte complexes, cumulus cells and denuded oocytes, and affects in vitro fertilization outcome. Scientific reports, 8(1), 12191. https://doi.org/10.1038/s41598-018-30774-223. Küme, T., Sağlam, B., Ergon, C., & Sisman, A. R. (2018). Evaluation and comparison of Abbott Jaffe and enzymatic creatinine methods: Could the old method meet the new requirements?. Journal of clinical laboratory analysis, 32(1), e22168. https://doi.org/10.1002/jcla.22168
24. Little, M. W., O'Connell, N. E., & Ferris, C. P. (2016). A comparison of individual cow versus group concentrate allocation strategies on dry matter intake, milk production, tissue changes, and fertility of Holstein-Friesian cows offered a grass silage diet. Journal of dairy science, 99(6), 4360–4373. https://doi.org/10.3168/jds.2015-10441
25. Liu, J., Cook, R., Danhof, L., Lopatto, D., Stoltzfus, J. R., & Benning, C. (2021). Connecting research and teaching introductory cell and molecular biology using an Arabidopsis mutant screen. Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology, 49(6), 926–934. https:// ьdoi.org/10.1002/bmb.21579
26. Liu, M. J., Bao, S., Napolitano, J. R., Burris, D. L., Yu, L., Tridandapani, S., & Knoell, D. L. (2014). Zinc regulates the acute phase response and serum amyloid A production in response to sepsis through JAK-STAT3 signaling. PloS one, 9(4), e94934. https://doi.org/10.1371/journal.pone.0094934
27. Moradi, M., Zhandi, M., Sharafi, M., Akbari, A., Atrabi, M. J., & Totonchi, M. (2022). Gene expression profile of placentomes and clinical parameters in the cows with retained placenta. BMC genomics, 23(1), 760. https://doi.org/10.1186/s12864-022-08989-5.
28. Moura, Francyelle & Ferreira, Bruno & Muniz, Elusca & Justino, Allisson & Silva, Ana & Ribeiro, Rosy & Dantas, Noelio & Ribeiro, Daniele & Araújo, Fernanda & Espindola, Foued & Almeida Silva, Anielle Christine & Tomiosso, Tatiana. (2022). Antioxidant, anti-inflammatory, and wound healing effects of topical silver-doped zinc oxide and silver oxide
nanocomposites. International Journal of Pharmaceutics. 617. 121620. https://doi.org/10.1016/j.ijpharm.2022.121620.
29. Pontes, G.C.S. & Monteiro Jr, Pedro & Prata, Alexandre & Guardieiro, M.M. & Pinto, D.A.M. & Fernandes, G.O. & Wiltbank, M.C. & Santos, Jose & Sartori, Roberto. (2015). Effect of injectable vitamin E on incidence of retained fetal membranes and reproductive performance of dairy cows. Journal of Dairy Science. 98. https://doi.org/10.3168/jds.2014-8886.
30. Raboisson, Didier & Albaaj, Ahmad & Nonne, G. & Foucras, Gilles. (2017). High urea and pregnancy or conception in dairy cows: A meta-analysis to define the appropriate urea threshold. Journal of Dairy Science. 100. https://doi.org/10.3168/jds.2016-12009.
31. Schimmel, P., Kleinjans, L., Bongers, R. S., Knol, J., & Belzer, C. (2021). Breast milk urea as a nitrogen source for urease positive Bifidobacterium infantis. FEMS microbiology ecology, 97(3), fiab019. https://doi.org/10.1093/femsec/fiab019
32. Singh, S., Sharma, M., & Singh, G. (2021). Recent advancements in urea biosensors for biomedical applications. IET nanobiotechnology, 15(4), 358–379. https://doi.org/10.1049/nbt2.12050
33. Szentirmai, V., Wacha, A., Németh, C., Kitka, D., Rácz, A., Héberger, K., Mihály, J., & Varga, Z. (2020). Reagent-free total protein quantification of intact extracellular vesicles by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy. Analytical and bioanalytical chemistry, 412(19), 4619–4628. https://doi.org/10.1007/s00216-020-02711-8
34. Vailati-Riboni, M., Osorio, J. S., Trevisi, E., Luchini, D., & Loor, J. J. (2017). Supplemental Smartamine M in higherenergy diets during the prepartal period improves hepatic biomarkers of health and oxidative status in Holstein cows. Journal of animal science and biotechnology, 8, 17. https://doi.org/10.1186/s40104-017-0147-7
35. Yerra, Veera Ganesh & Drosatos, Konstantinos. (2023). Specificity Proteins (SP) and Krüppel-like Factors (KLF) in Liver Physiology and Pathology. International Journal of Molecular Sciences. 24. 4682. https://doi.org/10.3390/ijms24054682.
36. Zangeronimo, Marcio & Oberlender, Guilherme & Solis-Murgas, Luis. (2013). Effect of nutrition on the reproduction in gilts – a review. Revista Científica Eletrônica de Medicina Veterinária. XI. 1-20.
37. Zhao, C., Shu, S., Bai, Y., Wang, D., Xia, C., & Xu, C. (2019). Plasma Protein Comparison between Dairy Cows with Inactive Ovaries and Estrus. Scientific reports, 9(1), 13709. https://doi.org/10.1038/s41598-019-49785-8
Published
2023-09-19
How to Cite
O. M., C., & V. O., D. (2023). THE EFFECT OF A COMBINED CHANGE OF SOME INDICATORS OF HOMEOSTASIS ON THE REPRODUCTIVE FUNCTION OF COWS. Bulletin of Sumy National Agrarian University. The Series: Veterinary Medicine, (2(61), 55-61. https://doi.org/10.32782/bsnau.vet.2023.2.8
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