EFFECTIVENESS OF COMBINED THERAPY UNDER CATTLE FASCIOLOSIS
Abstract
Therapeutic effectiveness of anthelmintics Brontel and Rafenzole and their effects on the functional state of the immune system were studied on cows-analogues aged 3–5 years, black and spotted breed, with body weight of 450–500 kg. Brontel 10% was injected in a dose of 1 cm3 per 10 kg of body weight subcutaneously in 2–3 portions in different parts of the animal body, once; Rafenzole was used in the form of a suspension in a dose of 1 cm3 per 10 kg of body weight orally. The intensity of the infestation in the experimental groups was 12,1–12,5 eggs in 12 feces. The effectiveness of Brontel was 100%, and a month after the application, the average daily yield of milk per cow in the experimental group exceeded the indicators of the control group by 2,8 kg, and after 2 months – by 3,1 kg. Brontel deworming ensured an increase in the number of erythrocytes in the blood of animals by 29,4%, hemoglobin by 8,19% when compared to the control group, as well as the improvement of the leukogram to physiologival limits. The preparation showed a positive effect on the animal’s organism. On the 21st and 30th days after deworming with the anthelmintic Rafenzole in combination with Bistum, positive changes in morphological parameters of the blood of cows were noted. On the 21st day, the animals’ bodies were completely free of helminths. During hemathological studies, an increase in the number of erythrocytes and segmentonuclear neutrophils was observed compared to the initial data, and the number of eosinophils and leykocytes decreased to the physiological limits. Among the biochemical indicators, an increase in the content of hemoglobin, glucose and total albumin protein was noted in relation to a control group. Therefore, the restoration of the above-described indicators to the norm is associated with the effect of the preparations on fasciols and cessation of the synthesis of their toxin in animal organism, which have an immunosuppressive effect. Thus, the mechanism of the action of Brontel 10% and Rufenzole consisted in reducing the toxic effect of fasciols, since the EE and IE of these preparations was 100%. The results of the study showed that when using a complex of preparations (Rafenzole + Bistum immune stimulator), the indicators of the immune status of the animals improved significantly. Therefore, Rafenzole and Bistum show significant stimulating effects on the bodies of cattle. Stimulation of animals with Bistum and deworming with Rafenzole contributed to a steady strenthening of the immune system and significantly increased the immune status of the body, as evidenced by the results of the study.
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