Протианемічна дія препаратів феруму у поросят
Ключові слова:
анемія, ферум, гексагідразидний клатрохелат, поросята, свиноматки
Анотація
У статті наведені результати досліджень протианемічної дії в організмі поросят Феруму у формі клатрохелату та у рідкісній нетрадиційній валентності IV. Дослідження проведено на поросятах-аналогах, яких розподілили у дві групи – контрольну та дослідну. Поросята дослідної групи були відібрані від свиноматок, яким у період вагітності двічі внутрішньом’язово вводили по 10 мл 10 % розчину клатрохелату Феруму(IV). Матеріалом для досліджень були маса тіла та сироваткa крові поросят. Дослід тривав 60 діб.
Результати досліджень засвідчили відсутність загибелі та анемії серед поросят дослідної групи, високу інтенсивність їх росту, що вказує на профілактичний ефект клатрохелату Феруму(IV), застосованого поросним свиноматкам. Встановлено, що маса тіла поросят дослідної групи не відрізнялась від маси тіла поросят контрольної групи; була меншою на 5 добу їх життя та перевищувала в усі послідуючі періоди вирощування, аж до відлучення. Нижчий вміст Феруму у сироватці крові поросят дослідної групи, ніж у контролі до 12 добового віку пояснюється особливостями його фармакокінетики – впливом плацентарного бар’єру.
Посилання
1. Batrakov, A., Travkin, O., & Jakovleva, E. (2005). Profilaktika alimentarnoj anemii u porosjat [Prevention of malignant anemia of piglets]. Veterinarija [Veterinary medicine], 12, 44–45 [in Russian].
2. Camaschella C. (2013). Iron and hepcidin: a story of recycling and balance. Hematology. American Society of Hema-tology. Education Program, 2013, 1–8. https://doi.org/10.1182/asheducation-2013.1.1
3. Ganz, T., & Nemeth, E. (2006). Iron imports. IV. Hepcidin and regulation of body iron metabolism. American journal of physiology. Gastrointestinal and liver physiology, 290(2), 199–203. https://doi.org/10.1152/ajpgi.00412.2005
4. Danchuk, V. (2002). Profilaktyka anemii u novonarodzhenykh porosiat [Prevention of anemia in newborn piglets]. Tvarynnytstvo Ukrainy [Livestock of Ukraine], 2. 23–25.
5. Derkach, I. (2017). Suchasni tendencii' na vitchyznjanomu rynku ferumvmisnyh preparativ dlja tvaryn [Modern trends of the Ukrainian market of ironcontaining products for animals]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 19(78), 23–25. doi.org/10.15421/nvlvet7805 [in Ukrainian].
6. Devillers N., Milgen van J., Prunier A. & Le J. Dividich (2004) Estimation of colostrum intake in the neonatal pig Animal Science, 78, 305–313.
7. Dukhnitsky, V. B., Derkach, I. M., Plutenko, M. O., Fritsky, I. O., & Derkach, S. S. (2018). Vyznachennja parametriv gostroi toksychnosti ferumu (IV) na bilyh myshah [Determination of the accumulative toxicity parameters of iron (IV) on white mice]. Ukrainian Journal of Ecology, 8 (2), 308–312. doi.org/10.15421/2018_343 [in Ukrainian].
8. Dukhnitsky, V., Derkach, I., Derkach, S., Fritsky, I., & Plutenko, M. (2019). Khronichna toksychnist klatrokhelatu Ferumu (IV) dlia bilykh shchuriv [Chronic toxicity of the Iron (IV) clathrochelate complexes for white rats]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 21(95), 15–21. https://doi.org/10.32718/nvlvet9503 [in Ukrainian].
9. Dukhnitsky, V. B., Derkach, I. M., Plutenko, M. O., Fritsky, I. O., & Derkach, S. S. (2019). Cumulative properties of Iron(IV) clathrochelate in rats [Kumuliatyvni vlastvosti klatrokhelatu Ferumu (IV) dlia bilykh shchuriv]. Visnyk PDAA [Messenger PDAA], 2, 238–246. doi: 10.31210/visnyk2019.02.32 [in Ukrainian].
10. Dukhnitsky, V., Derkach, I., Plutenko, M., Fritsky, I., & Derkach, S. (2019). Acute toxicity of the iron clathrochelate complexes. Regulatory Mechanisms in Biosystems, 10(3), 276–279. https://doi.org/10.15421/021942
11. Dukhnitsky, V. B., Derkach, I. M., Derkach, S. S., Plutenko, M. O. & Fritsky, I. O. (2019). Influence of iron (IV) clath-rochelate complex on quail blood parameters and weight characteristics. Ukrainian Journal of Ecology, 9 (3), 126–131. DOI: 10.15421/2019_719
12. Dukhnitsky, V., Derkach, I., Derkach, S., Fritsky, I., & Plutenko, M. (2020). Doslidzhennia podrazniuvalnoi dii ta alerhennykh vlastyvostei klatrokhelatu Ferumu(IV) [Investigations of the irritant effect and allergenic properties of Fermat's clatrochelate (IV)]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 22(97), 130–135. doi: 10.32718/nvlvet9721 [in Ukrainian].
13. Dukhnitsky, V., Derkach, I., Derkach, S., Fritsky, I., & Plutenko, M. (2020). Doslidzhennia protyanemichnoi dii klatrokhelatu Ferumu(IV) na porosiatakh [Study of the antianemic effect of iron (IV) clatrochelate on piglets]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 22(99), 107–115. doi: 10.32718/nvlvet9917 [in Ukrainian].
14. Dukhnitsky, V. B., Kalachniuk L.H., Derkach, I. M., Derkach, S. S., Plutenko, M. O. & Fritsky, I. O. (2020). Iron(IV) hexahydrazide clathrochelate complexes: the chronic toxicity study Ukrainian Journal of Ecology, 9 (3), 18–23. DOI: 10.15421/2020_3
15. Derkach, I. (2017). Suchasni tendencii na vitchyznjanomu rynku ferumvmisnyh preparativ dlja tvaryn [Modern trends of the Ukrainian market of ferumcontaining products for animals]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 19 (78), 23–25. doi.org/10.15421/nvlvet7805 [in Ukrainian].
16. Evans, J. L., & Abraham, P. A. (1973). Anemia, Iron Storage and Ceruloplasmin in Copper Nutrition in the Growing Rat. The Journal of Nutrition. 103 (2, 1), 196−201. https://doi.org/10.1093/jn/103.2.196
17. Framstad, T. & Sjaastad, O. (1991). Iron supplementation in piglets. Norsk Veterinaertidsskrift, , 103, 21–27.
18. Ganz, T. (2013). Systemic iron homeostasis. Physiological Reviews. 93 (4). 1721−1741. doi: 10.1152/physrev.00008
19. Karelyn A.Y. (1983) Anemyia porosiat [Anemia of piglets]. Moskwa. Rosselkhozyzdat [in Russian].
20. Karput' I. M., & Nikoladze M. G. (2001). Diagnostika i profilaktika alimentarnoj anemii porosjat [Diagnosis and prevention of alimentary anemia of piglets]. Veterinarija [Veterinary medicine], 4, 34−37 [in Russian].
21. Karput' I. M., & Nikoladze M. G. (2003). Obmen zheleza u zdorovyh i bol'nyh alimentarnoj anemiej porosjat [Iron me-tabolism in healthy and sick piglets with alimentary anemia]. Bulletin of the Academy of Agrarian Sciences of the Republic of Belarus [Izvestiya Akademii Agrarian Sciences of the Republic of Belarus], 4, 34−37 [in Russian].
22. Kegley E.B., Speers J.W., Flowers W.L., & Schoenherr W.D. (2002). Iron methionine as a source of iron for the neonatal pig. Nutrition research. 22, 1209–1217.
23. Kim, J.C., Wilcock, P., & Bedford, M.R. (2018). Iron status of piglets and impact of phytase superdosing on iron physi-ology: A review. Animal Feed Science and Technology. 235, 8−14.
24. Killip, S., & Bennett, M. Iron Deficiency Anemia (2008). American Family Physician. 15, 78 (8), 671−678.
25. Kocjumbas I. J. (2006) Doklinichni doslidzhennja veterynarnyh likars'kyh zasobiv [Preclinical studies of veterinary drugs]. L'viv. Triada pljus [in Ukrainian].
26. Leyshon, B. J., Radlowski, E. C., Mudd, A. T., Steelman, A. J., & Johnson, R. W. (2016). Postnatal Iron Deficiency Alters Brain Development in Piglets. The Journal of nutrition, 146(7), 1420–1427. https://doi.org/10.3945/jn.115.223636
27. Levchenko V. I., Kondrakhin I. P., & Vlizlo V.V. (2012). Vnutrishni khvoroby tvaryn. Chastyna 1 [Internal diseases of an-imals. Part 1]. Bila Tserkva.
28. Polkovenko O.V. (2010). Znachennia midi dlia zdorov‘ia liudyny [The value of copper for human health]. Kultura bezpeky ekolohii ta zdorov‘ia [Culture of environmental safety and health]. 3, 33–35.
29. Prystupa, T.I., Danchuk, V.V., Danchuk, O.V., & Kaplunenko V.H. (2013). Rukhova aktyvnist porosiat-sysuniv za vvedennia spoluk ferumu [Motor activity of suckling piglets with the introduction of iron compounds]. Naukovyi visnyk veterynarnoi medytsyny [Scientific Bulletin of Veterinary Medicine], 12(107), 60–63.
30. Roy, C. N., & Enns, C. A. (2000) Iron homeostasis: new tales from the crypt. Blood, 96(13), 4020–4027.
31. Svoboda, M., & Drabek, J. (2005). Iron deficiency in suckling piglets: etiology, clinical aspects and diagnosis. Folia Veterinaria., 49, 104–111.
32. Tomyn, S., Shylin, S. I., Bykov, D., Ksenofontov, V., Gumienna-Kontecka, E., Bon, V. & Fritsky, I.O. (2017) Indefinitely stable iron (IV) cage complexes formed in water by air oxidation. Nature Communications. 8, 1−8.
33. Vered, P. I. (2003). Vyvchennia dii proty anemichnykh preparativ vitchyznianoho vyrobnytstva na orhanizm porosiat [Study of action against anemic drugs of domestic production on the body of piglets]. Zbirnyk materialiv III mizhvuzivskoi naukovo-praktychnoi konferentsii aspirantiv «Suchasna ahrarna nauka: napriamy doslidzhen, stan i perspektyvy» [Proceedings of the III Interuniversity Scientific and Practical Conference of Postgraduate Students "Modern Agricultural Science: Areas of Research, Status and Prospects"]. Vinnytsia, 222–223.
34. Vydyborets, S. V. & Andriiaka, A. O. (2017). Fiziolohichna rol hepsydynu yak tsentralnoho rehuliatora metabolizmu zaliza (Ohliad literatury) [Physiological role of hepcidin as a central regulator of iron metabolism (Literature review)] Semeinaia medytsyna [Family medicine], 1(69), 154–157.
35. Zimmermann, W. (1995). Auswirkungen diverser Anamieprohylaxeformen auf die Blutprameter der Saugferkel. Dtsch. Tierarztl. Wsch., 102, 32–38.
36. Walter, T., Olivares, M., Pizarro, F. & Muñoz, C. (1997). Iron, Anemia, and Infection. Nutrition Reviews. 55 (4), 111−124. doi: 10.1111/j.1753-4887.1997.tb06462.x
2. Camaschella C. (2013). Iron and hepcidin: a story of recycling and balance. Hematology. American Society of Hema-tology. Education Program, 2013, 1–8. https://doi.org/10.1182/asheducation-2013.1.1
3. Ganz, T., & Nemeth, E. (2006). Iron imports. IV. Hepcidin and regulation of body iron metabolism. American journal of physiology. Gastrointestinal and liver physiology, 290(2), 199–203. https://doi.org/10.1152/ajpgi.00412.2005
4. Danchuk, V. (2002). Profilaktyka anemii u novonarodzhenykh porosiat [Prevention of anemia in newborn piglets]. Tvarynnytstvo Ukrainy [Livestock of Ukraine], 2. 23–25.
5. Derkach, I. (2017). Suchasni tendencii' na vitchyznjanomu rynku ferumvmisnyh preparativ dlja tvaryn [Modern trends of the Ukrainian market of ironcontaining products for animals]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 19(78), 23–25. doi.org/10.15421/nvlvet7805 [in Ukrainian].
6. Devillers N., Milgen van J., Prunier A. & Le J. Dividich (2004) Estimation of colostrum intake in the neonatal pig Animal Science, 78, 305–313.
7. Dukhnitsky, V. B., Derkach, I. M., Plutenko, M. O., Fritsky, I. O., & Derkach, S. S. (2018). Vyznachennja parametriv gostroi toksychnosti ferumu (IV) na bilyh myshah [Determination of the accumulative toxicity parameters of iron (IV) on white mice]. Ukrainian Journal of Ecology, 8 (2), 308–312. doi.org/10.15421/2018_343 [in Ukrainian].
8. Dukhnitsky, V., Derkach, I., Derkach, S., Fritsky, I., & Plutenko, M. (2019). Khronichna toksychnist klatrokhelatu Ferumu (IV) dlia bilykh shchuriv [Chronic toxicity of the Iron (IV) clathrochelate complexes for white rats]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 21(95), 15–21. https://doi.org/10.32718/nvlvet9503 [in Ukrainian].
9. Dukhnitsky, V. B., Derkach, I. M., Plutenko, M. O., Fritsky, I. O., & Derkach, S. S. (2019). Cumulative properties of Iron(IV) clathrochelate in rats [Kumuliatyvni vlastvosti klatrokhelatu Ferumu (IV) dlia bilykh shchuriv]. Visnyk PDAA [Messenger PDAA], 2, 238–246. doi: 10.31210/visnyk2019.02.32 [in Ukrainian].
10. Dukhnitsky, V., Derkach, I., Plutenko, M., Fritsky, I., & Derkach, S. (2019). Acute toxicity of the iron clathrochelate complexes. Regulatory Mechanisms in Biosystems, 10(3), 276–279. https://doi.org/10.15421/021942
11. Dukhnitsky, V. B., Derkach, I. M., Derkach, S. S., Plutenko, M. O. & Fritsky, I. O. (2019). Influence of iron (IV) clath-rochelate complex on quail blood parameters and weight characteristics. Ukrainian Journal of Ecology, 9 (3), 126–131. DOI: 10.15421/2019_719
12. Dukhnitsky, V., Derkach, I., Derkach, S., Fritsky, I., & Plutenko, M. (2020). Doslidzhennia podrazniuvalnoi dii ta alerhennykh vlastyvostei klatrokhelatu Ferumu(IV) [Investigations of the irritant effect and allergenic properties of Fermat's clatrochelate (IV)]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 22(97), 130–135. doi: 10.32718/nvlvet9721 [in Ukrainian].
13. Dukhnitsky, V., Derkach, I., Derkach, S., Fritsky, I., & Plutenko, M. (2020). Doslidzhennia protyanemichnoi dii klatrokhelatu Ferumu(IV) na porosiatakh [Study of the antianemic effect of iron (IV) clatrochelate on piglets]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 22(99), 107–115. doi: 10.32718/nvlvet9917 [in Ukrainian].
14. Dukhnitsky, V. B., Kalachniuk L.H., Derkach, I. M., Derkach, S. S., Plutenko, M. O. & Fritsky, I. O. (2020). Iron(IV) hexahydrazide clathrochelate complexes: the chronic toxicity study Ukrainian Journal of Ecology, 9 (3), 18–23. DOI: 10.15421/2020_3
15. Derkach, I. (2017). Suchasni tendencii na vitchyznjanomu rynku ferumvmisnyh preparativ dlja tvaryn [Modern trends of the Ukrainian market of ferumcontaining products for animals]. Naukovyj visnyk Lvivskogo nacionalnogo universytetu veterynarnoi medycyny ta biotehnologij imeni S. Z. Gzhyckogo [Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences], 19 (78), 23–25. doi.org/10.15421/nvlvet7805 [in Ukrainian].
16. Evans, J. L., & Abraham, P. A. (1973). Anemia, Iron Storage and Ceruloplasmin in Copper Nutrition in the Growing Rat. The Journal of Nutrition. 103 (2, 1), 196−201. https://doi.org/10.1093/jn/103.2.196
17. Framstad, T. & Sjaastad, O. (1991). Iron supplementation in piglets. Norsk Veterinaertidsskrift, , 103, 21–27.
18. Ganz, T. (2013). Systemic iron homeostasis. Physiological Reviews. 93 (4). 1721−1741. doi: 10.1152/physrev.00008
19. Karelyn A.Y. (1983) Anemyia porosiat [Anemia of piglets]. Moskwa. Rosselkhozyzdat [in Russian].
20. Karput' I. M., & Nikoladze M. G. (2001). Diagnostika i profilaktika alimentarnoj anemii porosjat [Diagnosis and prevention of alimentary anemia of piglets]. Veterinarija [Veterinary medicine], 4, 34−37 [in Russian].
21. Karput' I. M., & Nikoladze M. G. (2003). Obmen zheleza u zdorovyh i bol'nyh alimentarnoj anemiej porosjat [Iron me-tabolism in healthy and sick piglets with alimentary anemia]. Bulletin of the Academy of Agrarian Sciences of the Republic of Belarus [Izvestiya Akademii Agrarian Sciences of the Republic of Belarus], 4, 34−37 [in Russian].
22. Kegley E.B., Speers J.W., Flowers W.L., & Schoenherr W.D. (2002). Iron methionine as a source of iron for the neonatal pig. Nutrition research. 22, 1209–1217.
23. Kim, J.C., Wilcock, P., & Bedford, M.R. (2018). Iron status of piglets and impact of phytase superdosing on iron physi-ology: A review. Animal Feed Science and Technology. 235, 8−14.
24. Killip, S., & Bennett, M. Iron Deficiency Anemia (2008). American Family Physician. 15, 78 (8), 671−678.
25. Kocjumbas I. J. (2006) Doklinichni doslidzhennja veterynarnyh likars'kyh zasobiv [Preclinical studies of veterinary drugs]. L'viv. Triada pljus [in Ukrainian].
26. Leyshon, B. J., Radlowski, E. C., Mudd, A. T., Steelman, A. J., & Johnson, R. W. (2016). Postnatal Iron Deficiency Alters Brain Development in Piglets. The Journal of nutrition, 146(7), 1420–1427. https://doi.org/10.3945/jn.115.223636
27. Levchenko V. I., Kondrakhin I. P., & Vlizlo V.V. (2012). Vnutrishni khvoroby tvaryn. Chastyna 1 [Internal diseases of an-imals. Part 1]. Bila Tserkva.
28. Polkovenko O.V. (2010). Znachennia midi dlia zdorov‘ia liudyny [The value of copper for human health]. Kultura bezpeky ekolohii ta zdorov‘ia [Culture of environmental safety and health]. 3, 33–35.
29. Prystupa, T.I., Danchuk, V.V., Danchuk, O.V., & Kaplunenko V.H. (2013). Rukhova aktyvnist porosiat-sysuniv za vvedennia spoluk ferumu [Motor activity of suckling piglets with the introduction of iron compounds]. Naukovyi visnyk veterynarnoi medytsyny [Scientific Bulletin of Veterinary Medicine], 12(107), 60–63.
30. Roy, C. N., & Enns, C. A. (2000) Iron homeostasis: new tales from the crypt. Blood, 96(13), 4020–4027.
31. Svoboda, M., & Drabek, J. (2005). Iron deficiency in suckling piglets: etiology, clinical aspects and diagnosis. Folia Veterinaria., 49, 104–111.
32. Tomyn, S., Shylin, S. I., Bykov, D., Ksenofontov, V., Gumienna-Kontecka, E., Bon, V. & Fritsky, I.O. (2017) Indefinitely stable iron (IV) cage complexes formed in water by air oxidation. Nature Communications. 8, 1−8.
33. Vered, P. I. (2003). Vyvchennia dii proty anemichnykh preparativ vitchyznianoho vyrobnytstva na orhanizm porosiat [Study of action against anemic drugs of domestic production on the body of piglets]. Zbirnyk materialiv III mizhvuzivskoi naukovo-praktychnoi konferentsii aspirantiv «Suchasna ahrarna nauka: napriamy doslidzhen, stan i perspektyvy» [Proceedings of the III Interuniversity Scientific and Practical Conference of Postgraduate Students "Modern Agricultural Science: Areas of Research, Status and Prospects"]. Vinnytsia, 222–223.
34. Vydyborets, S. V. & Andriiaka, A. O. (2017). Fiziolohichna rol hepsydynu yak tsentralnoho rehuliatora metabolizmu zaliza (Ohliad literatury) [Physiological role of hepcidin as a central regulator of iron metabolism (Literature review)] Semeinaia medytsyna [Family medicine], 1(69), 154–157.
35. Zimmermann, W. (1995). Auswirkungen diverser Anamieprohylaxeformen auf die Blutprameter der Saugferkel. Dtsch. Tierarztl. Wsch., 102, 32–38.
36. Walter, T., Olivares, M., Pizarro, F. & Muñoz, C. (1997). Iron, Anemia, and Infection. Nutrition Reviews. 55 (4), 111−124. doi: 10.1111/j.1753-4887.1997.tb06462.x
Опубліковано
2020-12-28
Як цитувати
Духницький, В., Деркач, І., Деркач, С., Фрицький, І., & Плутенко, М. (2020). Протианемічна дія препаратів феруму у поросят. Вісник Сумського національного аграрного університету. Серія: Ветеринарна медицина, (4 (51), 46-51. https://doi.org/10.32845/bsnau.vet.2020.4.7
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