ARTICLE REVIEW APPLICATION OF BIO ADDITIVES: NUTRICEUTICS, PARAMPHARMATICS, PROBIOTICS IN THE DIETS OF COMPANION ANIMALS

Keywords: cats, fat-soluble vitamins, nutraceuticals, probiotics, prebiotics, fatty acids

Abstract

Over the last decade, the use of supplements in human nutrition has become quite popular, and now it also occurs in pet nutrition, namely the use of supplements in the diets of dogs and cats is quite common around the world and in Ukraine. But the use of biological additives in the diets of domestic animals has a lot of controversy, there are doubts that the use of organic supplements in the diets of companion animals makes sense, and there are research results that show even the harm of improper use. And there is still a claim among animal owners that the cat as a obligate predator eats meat and does not need any other food (such as plant). Many cat owners generally feed their pets only meat, fish and milk. There are already many studies that such food is not only not useful, but also dangerous for the animal. Any predator, and in particular the cat, needs carbohydrates, vitamins, minerals, fatty acids and other components of plant foods. The diet of cats must be balanced, the intake of four particularly important components: proteins, fats, carbohydrates, vitamins and trace elements is essential and the lack or excess of any of them leads to metabolic disorders and causes great harm health. Another interesting issue is the use of probiotics and prebiotics, their impact on the immune system of animals, around the feasibility and usefulness of their use to companion animals, namely cats, there are many discussions. The aim of our work was to develop and analyze current research on the use of supplements in the diets of companion animals, analyze the classification of supplements, study their characteristics and justify the principles of selection of these supplements by pet owners. After studying a large number of studies, it can be noted that the use of supplements for cat food has its important potential, but still it is the veterinarian must choose the optimal diet with appropriate supplements and for this the doctor must collect a dietary history. It is the veterinarian who should help the pet owner to navigate the market of bioadditives designed for special nutritional purposes and choose the most optimal of them for their pets.

References

1. Allison, R.W., E.D. Lassen, M.J. Burkhard and M.R. Lapin. 2000. Effect of a bioflavonoid dietary supplement on acetaminophen-induced oxidative injury to feline erythrocytes. J. Am. Vet. Med. Assoc. 217:1157-1161.
2. Anderson, M.A., M.R. Slater and T.A. Hammad. 2001. Results of a survey of small-animal practitioners on the perceived clinical efficacy and safety of an oral nutraceuticals. Preventative Vet. Med. 38:65-73.
3. Anonymous 1999. The geriatric cat. Fel. Prac. 24:5- 9. Bang, H.O., J. Dyerberg and N. Hjoerne. 1976. The composition of food consumed by Greenland Eskimos. Acta Med. Scand. 200: 69-73.
4. Baskin, C.R.; K.W. Hinchcliff, R.A. DiSilvestro, G.A. Reinhart, M.G. Hayek, B.P. Chew, J.R. Burr and R.A. Swenson. 2000. Effects of dietary antioxidant supplementation on oxidative damage and resistance to oxidative damage during prolonged exercise in sled dogs. Am. J. Vet. Res. 61:886-891.
5. Billman, G.E., H. Hallaq and A. Leaf. 1999. Prevention of ischemia-induced ventricular fibrillation by ω-3 fatty acids. Proc. Natl. Acad. Sci. 92:4427-4430.
6. Biourge, V., C. Vallet, A. Levesque, R. Sergheraert, S. Chevalier and J.-L. Roberton. 1999. The use of probiotics in the diet of dogs. J. Nutr. 128:2730S- 2732S.
7. Canapp, S.O., R.M. McLaughlin, J.J. Hoskinson, J.K. Roush and M.D. Butine. 1999. Scintographic evaluation of dogs with acute synovitis after treatment with glucosamine hydrochloride and chondroitin sulfate. Am. J. Vet. Res. 60:1552- 1557.
8. Chew, B.P., J.S. Park, T.S. Wong, H.W. Kim, B.B. Weng, K.M. Byrne, M.G. Hayek and G.A. Reinhart. 2000. Dietary beta-carotene stimulates cell-mediated and humoral immune response in dogs. J. Nutr. 130:1910-1913.
9. Cotman, C.A., E. Head, B.A. Muggenburg, S. Zicker and N.W. Milgram. 2002. Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Neurobiol. Aging 23:809- 818.
10. Devis А. Nutraceuticals: Nutrition for life, health and longevity. - M., 2004
11. Flickinger, E.A. and G.C. Fahey. 2002. Pet food and feed applications of inulin, oligofructose and other oligosaccharides. Brit. J. Nutr. 87: S297- S300.
12. Fuller, R. 1995. Probiotics in man and animals. J. Appl. Bacteriol. 66:365-378.
13. Gibson, G.R., E.R. Beatty, X. Wang and J.H. Cummings. 1999. Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 108:975-982.
14. Greaves, J., J. Mann and J. Haworth. 2001. Natural alternatives. Petfood Ind. March:28-30.
15. Hamilton-Miller, J.M.T., S. Shah and T. Smith. 1999. “Probiotic” remedies are not what they seem. Brit. Med. J. 312: 55-56.
16. Hayek, M.G., S.P. Massimino, J.R. Burr and R.J. Kearns. 2000. Dietary vitamin E improves immune function in cats. In: Recent Advances in Canine and Feline Nutrition. Vol III. (G.A. Reinhart and D.P. Carey, eds), Orange Frazer Press, Wilmington, Ohio, pp. 555-603.
17. Hendriks, W. H.; Y.B. Wu, R.G. Shields, M. Newcomb, K.J. Rutherfurd, T. Belay, and J. Wilson. 2002. Vitamin E requirement of adult cats increases slightly with high dietary intake of polyunsaturated fatty acids. J. Nutr. 132:1613S-1615S.
18. Hesta, M., G.P.J. Janssens, J. Debraekeleer and R. DeWilde. 2001. The effects of oligofructose and inulin on faecal characteristics and nutrient digestibility in healthy cats. J. Anim. Physiol. Anim. Nutr. 85:135-141.
19. Hill, A.S., S. O’Neill, Q.R. Rogers and M.M. Christopher. 2001. Antioxidant prevention of Heinz body formation and oxidative injury in cats. Am. J. Vet. Res. 62:370-374.
20. Hoff, G.L., J. Brawley and K. Johnson. 1999. Companion animal issues and the physician. Southern Med. J. 92:651-659.
21. Hussein, H.S., E.A. Flickinger and G.C. Fahey. 1999 Petfood applications of inulin and oligofructose. J. Nutr. 129:1454S-1456S.
22. Kearns, R.J., M.G. Hayek, J.J. Turek, M. Meydani, J.R. Burr, R.J. Greene, C.A. Marshall, S.M. Adams, R.C. Borgert and G.A. Reinhart. 1999 Effect of age, breed and dietary omega-6 (n-6): omega-3 (n-3) fatty acid ratio on immune function, eicosanoid production, and lipid peroxidation in young and aged dogs. Vet. Immunol. Immunopathol. 69: 165-183.
23. Kim, H.W., B.P. Chew, T.S. Wong, J.S. Park, B.B. Weng, K.M. Byrne, M.G. Hayek and G.A. Reinhart. 2000a. Modulation of humoral and cellmediated immune responses by dietary lutein in cats. Vet. Immunol. Immunopathol. 73:331-341.
24. Kim, H.W., B.P. Chew, T.S. Wong, J.S. Park, B.B. Weng, K.M. Byrne, M.G. Hayek and G.A. Reinhart. 2000b. Dietary lutein stimulates immune response in the canine. Vet. Immunol. Immunopathol. 74:315-327.
25. Lippiello, L., A. Idouraine, P.S. McNamara, S.C. Barr and R.M. McLaughlin. 1999. Cartilage stimulatory and antiproteolytic activity is present in sera of dogs treated with a chondroprotective agent. Canine Practice 24:18-19.
26. Lourens-Harringh, A. and B.C. Viljoen. 2001. Yoghurt as probiotic carrier food. Internat. Dairy J. 11:1-17.
27. McLennan, P.L., M.Y. Abeywardena and J.S. Charnock. 1998. Dietary fish oil prevents ventricular fibrillation following coronary artery occlusion and reperfusion. Am. Heart J. 16:709- 717.
28. McLennan, P.L., T.M. Bridle, M.Y. Abeywardena and J.S. Charnock. 1999. Comparative efficacy of n-3 and n-6 polyunsaturated fatty acids in modulating ventricular fibrillation threshold in marmoset monkeys. Am. J. Clin. Nutr. 58:7834- 7838.
29. Meydani, S.N., N. Hayek, D. Wu and M. Meydani. 1998. Vitamin E and immune response in aged dogs. In: Recent Advances in Canine and Feline Nutrition, Volume II. (R.A. Reinhart and D.P. Carey, eds). Orange Frazer Press, Wilmington, Ohio, p295-303.
30. Milgram, N.W., S.C. Zicker, E. Head, B.A. Muggenburg, H. Murphey, C.J. Ikeda-Douglas and C.W. Cotman. 2002a. Dietary enrichment counteracts age-associated cognitive dysfunction in canines. Neurobiol. Aging 23:737-745.
31. Milgram, N.W., E. Head, B.A. Muggenburg, D. Holowachuk, H. Murphey, J. Estrada, C.J. Ikeda- Douglas, S.C. Zicker and C.W. Cotman. 2002b. Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy. Neurosci. Biobehav. Rev. 26:679-695.
32. Mooney, M.A., D.M. Vaughn, G.A. Reinhart, R.D. Powers, J.C. Wright, C.E. Hoffman, S.F. Swaim and H.J. Baker. 1998. Evaluation of the effects of omega-3 fatty acid-containing diets on the inflammatory wound healing in dogs. Am. J. Vet. Res. 59:859-863.
33. Olson, P.N., and C. Moulton. 1999. Pet (dog and cat) overpopulation in the United States. J. Reprod. Fert. 47:433-438.
34. Piercy, R.J., K.W. Hinchcliff, P.S. Morley, R.A. Disilvestro, G.A. Reinhart, S.L. Nelson, Jr., K.E. Schmidt and A.M. Craig. 2001. Association between vitamin E and enhanced athletic performance in sled dogs. Med. Sci. Sports Exerc. 33:826-833.
35. Pool-Zobel, B., J. van Loo, J. Rowland and M. Roberfroid. 2002. Review of experimental evidence investigating the potential of prebiotic carbohydrtes inulin and oligofructose to reduce the risk of colon cancer. Brit. J. Nutr. 87:S273- 281.
36. Reinhart, G.A. 1999. Review of omega-3 fatty acids and dietary influences on tissue concentration. In: Recent advances in canine and feline nutritional research. Proceedings of the 1996 Iams International Nutrition Symposium. (D.P. Carey, S.A. Norton, S.M. Bolser, eds). Orange Frazer Press, Wilmington, OH. P. 235-242.
37. Roberfroid, M.B., J.A. van Loo, and E.R. Gibson. 1999. The bifidogenic nature of chicory inulin and its hydrolysis products. J. Nutr. 128:11-19.
38. Saavedra, J.M. 2001. Clinical applications of probiotic agents. Am. J. Clin. Nutr. 73:1147S- 1151S. a. Sinclair AJ, McLean JG, Monger EA 1999. Metabolism of linoleic acid in the cat. Lipids; 14: 932-6.
39. Scott, K.C., R.C. Hill, D.D. Lewis, R. Gronwall, D.A. Sundstrom, G.L. Jones and J. Harper. 2002. Serum ascorbic acid concentrations in previously unsupplemented greyhounds after administration of a single dose of ascorbic acid intravenously or per os. J. Anim. Phys. Anim. Nutr. 86:222-228.
40. Schrezenmeir, J. and M. de Vrese. 2001. Probiotics, prebiotics, and synbiotics- approaching a definition. Am. J. Clin. Nutr. 72:361S-364S.
41. Sparkes, A.H., K. Papasouliotis, G. Sunvold, G. Werrett, E.A. Gruffydd-Jones, K. Egan, T. J. Gruffydd-Jones and G. Reinhart. 1998. Effect of dietary supplementation with fructooligosaccharides on fecal flora of healthy cats. Am. J. Vet. Res. 59:436-440.
42. Swanson, K.S. and G.C. Fahey. 2002. Prebiotics in companion animal nutrition. In: Nutritional Biotechnology in the Feed and Food Industries. (T.P. Lyons and K.A. Jacques, eds), Nottingham University Press, Nottingham, UK, pp. 461-473.
43. Terada, A., H. Hara, T. Oishi, S. Matsui, T. Mitsuoka, S. Nakajyo, I. Fujimori and K. Hara. 1999. Effect of dietary lactosucrose on faecal flora and faecal metabolites of dogs. Microbiol. Ecol. Health. Dis. 5:87-92.
44. Tomomatsu, H. 1994. Health effects of oligosaccharides. Food Technol. 48:61-65.
45. Van Loo, J.A., J.H. Cummings, N. Delzenne, H.N. Englyst, A. Franck, M.J. Hopkins, N. Kok, G.T. Macfarlane, D.F. Newton, M.E. Quigley, M.R. Roberfroid, T. van Vleit and E.G.H. van den Heuvel. 1999. Functional food properties of nondigestible oligosaccharides: a consensus report from the ENDO project. Brit. J. Nutr. 81:121- 132.
46. Vaughn, D.M., G.A. Reinhart, S.F. Swaim, S.D. Lauten, C.A. Garner, M.K. Boudreaux, J.S. Spano, C.E. Hoffman and B. Conner. 1994. Evaluation of the effects of dietary n-6 to n-3 fatty acid ratios on leukotriene B synthesis in dog skin and neutrophils. Vet. Dermatol. 5:163-173.
47. Vickers, R.J., G.D. Sunvold, R.L. Kelley and G.A. Reinhart. 2001. Comparison of fermentation of selected fructooligosaccharides and other fiber substrates by canine colonic microflora. Am. J. Vet. Res. 62:609-615.
48. Wander, R.C., J.A. Hall, J.L. Gradin, S.-H. Du and D.E. Jewell. 1997. The ratio of dietary (n-6) to (n-3) fatty acids influences immune system function, eicosanoid metabolism, lipid peroxidation and vitamin E status in aged dogs. J. Nutr. 127:1198-1205.
49. Wang, X. and G.R. Gibson. 1993. Effects of the fermentation of oligofructose and inulin by bacteria growing in the human large intestine. J. Appl. Bact. 75:373-380.
50. Weese, J.S. 2002. Microbiological evaluation of commercial probiotics. J. Am. Vet. Med. Assoc. 200:794-797.
51. Weese, J.S. and M.E.C. Anderson 2002. Preliminary evaluation of Lactobaccillus rhamnosus strain GG, a potential probiotic in dogs. Can. Vet. J. 43 :771-774.
52. Wildman, R.E.C. 2000. Classifying nutraceuticals. In: Handbook of Nutraceuticals and Functional Foods. (R.E.C. Wildman, ed). CRC Press, Boca Raton, Florida, p13-30.
53. Willard, M.D., R.B. Simpson, N.D. Cohen and J.S. Clancy. 2000. Effects of dietary fructooligosaccharide on selected bacterial populations in feces of dogs. Am. J. Vet. Res. 61:820-825.
54. Younger, K.M. 2002. Dietary reference standards. In: Introduction to Human Nutrition (M.J. Gibney, H.H. Vorster and F.J. Kok, eds). Blackwell Science, Oxford, UK, p116-124.
55. Lewis L.D.; Morris M.L., Hand M.S. Criteria for the selection of food for dogs and cats. Small animal clinical nutrition III. Topeka, KS: Mark Morris Associates, 1987. URL: http://www.ветеринарная-диетология.рф/kriterii-podborakorma-dlyasobak-i-koshek
56. Рацион питания домашних кошек. https://www.purinaone.ru/cat/catmag/ nutrition/ feeding-indoor-cat
57. Tobie C, Péron F, Larose C. Assessing Food Preferences in Dogs and Cats: A Review of the Current Methods. Animals (Basel). 2015;5(1):126-137. Published 2015 Mar 18. URL: doi:10.3390/ani5010126
58. Brown, C.A., Elliot, J., Schmiedt, S.W., and Brown, S.A. (2016). Chronic Kidney Disease in Aged Cats: Clinical Features, Morphology, and Proposed Pathogeneses. Vet. Pathol.53 (2), 309- 326. doi: 10.1177/0300985815622975. a. Commission Directive 2008/38/EC of 5 March 2008 establishing a list of intended uses of animal feedingstuffs for particular nutritional purposes - Available from: https://eurlex.europa.eu/legal-content/en/ALL/?uri=CELEX:32008L0038
59. Commission Regulation (EU) 2020/354 of 4 March 2020 establishing a list of intended uses of feed intended for particular nutritional purposes and repealing Directive 2008/38/EC Available from: https://eurlex.europa.eu/legalcontent/EN/TXT/?uri=uriserv:OJ.L_.2020.067.01.0001.01.ENG&toc=OJ:L:2020:067:TOC
60. Downes, M.J., Devit, C., Downes, M.T., and More, S.J. (2017). Understanding the context for pet cat and dog feeding and exercising behaviour among pet owners in Ireland: a qualitative study. Ir Vet J. 70: 29. doi: 10.1186/s13620-017-0107-8.
61. Finch, N.C., Syme, H.M., Elliot, J. (2016). Risk factors for development of chronic kidney disease in cats. J. Vet. Intern. Med., 30(2), 602-610. doi: 10.1111/jvim.13917. Epub 2016 Mar 6.
62. Linder, D.E. & Parker, V.J. (2016). Dietary aspects of weight management in cats and dogs. Vet. Clin. North Am. Small Anim. Pract. 46 (5), 869-882. doi: 10.1016/j.cvsm.2016.04.008 102 a. Makielski, K., Cullen, J., O’Connor, A., and Jergens, A.E. (2019). Narrative review of therapies for chronic enteropathies in dogs and cats. J Vet Intern Med. 33(1): 11–22. doi: 10.1111/jvim.15345.
63. Mamchyn, М.М. (2018). Rynok kormiv dlya domashnih tvaryn v Ukraini: marketyngovi aspekty. Ekonomika ta suspilstvo, 14, 202-207. Available from:https://journals.indexcopernicus.com/api/file/viewByFileId/765991.pdf [in Ukrainian]. a. Manei, S., Szakacs, A., Căpîlnean, A., and Macr, A. (2017). Nutritional Management of Overweight and Obesity in Dogs and Cats Bulletin UASVM Veterinary Medicine 74(1), 82-87. b. Mueller, R.S., Olivry, T., Prélaud, P. (2016). Critically appraised topic on adverse food reactions of companion animals [2]: common food allergen sources in dogs and cats. BMJ. Vet .Res.,1,.9. c. Piyarungsri, K. & Pusoonthornthum, R. (2017). Risk and protective factors for cats with naturally occurring chronic kidney disease. J. Feline Med Surg.19(4), 358-363. doi: 10.1177/1098612X15625453.
64. Regulation (ЕС) No 1831/2003 of the European Parliament and of the Council of 22 September 2003 on additives for use in animal nutrition Available from: https://eurlex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32003R1831.
a. Regulation (EC) No 767/2009 of the European Parliament and of the Council of 13 July 2009 on the placing on the market and use of feed, amending European Parliament and Council. Available from: https://eur-lex.europa.eu/legalcontent/EN/ALL/?uri=celex:32009R0767. Salaun, F., Blanchard, G., Le Paih, L., et al. (2017).
b. Impact of macronutrient composition and palatability in wet diets on food selection in cats. J Anim Physiol Anim Nutr (Berl). 101(2), 320-328. Sirenko, S. (2019).
65. Vyvchennya rynky і formuvannya popytu na rynku kormiv dlya domashnikh tvaryn. Ekonomika ta upravlinnya pidpryemstvamy, 32, 213-217. [in Ukrainian]. Zakon Ukrainu “Pro bezpechnist ta higienu kormiv”, vid 21 Grudnya 2017. Available from: https://zakon.rada.gov.ua/laws/show/2264-19.
66. Swanson and Fahey (2002). Повний огляд застосування пребіотиків у домашніх тварин.
67. Brown, C.A., Elliot, J., Schmiedt, S.W., and Brown, S.A. (2016). Chronic Kidney Disease in Aged Cats: Clinical Features, Morphology, and Proposed Pathogeneses. Vet. Pathol.53 (2), 309- 326. doi: 10.1177/0300985815622975.
68. Commission Directive 2008/38/EC of 5 March 2008 establishing a list of intended uses of animal feedingstuffs for particular nutritional purposes - Available from: https://eurlex.europa.eu/legal-content/en/ALL/?uri=CELEX:32008L0038 Commission Regulation (EU) 2020/354 of 4 March 2020 establishing a list of intended uses of feed intended for particular nutritional purposes and repealing Directive 2008/38/EC Available from: https://eur-lex.europa.eu/legalcontent/EN/TXT/?uri=uriserv:OJ.L_.2020.067.01.0001.01.ENG&toc=OJ:L:2020:067:TOC
a. Downes, M.J., Devit, C., Downes, M.T., and More, S.J. (2017). Understanding the context for pet cat and dog feeding and exercising behaviour among pet owners in Ireland: a qualitative study. Ir Vet J. 70: 29. doi: 10.1186/s13620-017-0107-8.
69. Finch, N.C., Syme, H.M., Elliot, J. (2016). Risk factors for development of chronic kidney disease in cats. J. Vet. Intern. Med., 30(2), 602-610. doi: 10.1111/jvim.13917. Epub 2016 Mar 6.
70. Linder, D.E. & Parker, V.J. (2016). Dietary aspects of weight management in cats and dogs. Vet. Clin. North Am. Small Anim. Pract. 46 (5), 869-882. doi: 10.1016/j.cvsm.2016.04.008 102 Makielski, K., Cullen, J., O’Connor, A., and Jergens, A.E. (2019). Narrative review of therapies for chronic enteropathies in dogs and cats. J Vet Intern Med. 33(1): 11–22. doi: 10.1111/jvim.15345.
71. Mamchyn, М.М. (2018). Rynok kormiv dlya domashnih tvaryn v Ukraini: marketyngovi aspekty. Ekonomika ta suspilstvo, 14, 202-207. Available from:https://journals.indexcopernicus.com/api/file/viewByFileId/765991.pdf [in Ukrainian].
72. Manei, S., Szakacs, A., Căpîlnean, A., and Macr, A. (2017). Nutritional Management of Overweight and Obesity in Dogs and Cats Bulletin UASVM Veterinary Medicine 74(1), 82-87.
73. Mueller, R.S., Olivry, T., Prélaud, P. (2016). Critically appraised topic on adverse food reactions of companion animals [2]: common food allergen sources in dogs and cats. BMJ. Vet .Res.,1,.9.
74. Piyarungsri, K. & Pusoonthornthum, R. (2017). Risk and protective factors for cats with naturally occurring chronic kidney disease. J. Feline Med Surg.19(4), 358-363. doi: 10.1177/1098612X15625453.
75. Regulation (ЕС) No 1831/2003 of the European Parliament and of the Council of 22 September 2003 on additives for use in animal nutrition Available from: https://eurlex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32003R1831.
76. Regulation (EC) No 767/2009 of the European Parliament and of the Council of 13 July 2009 on the placing on the market and use of feed, amending European Parliament and Council. Available from: https://eur-lex.europa.eu/legalcontent/EN/ALL/?uri=celex:32009R0767.
77. Salaun, F., Blanchard, G., Le Paih, L., et al. (2017). Impact of macronutrient composition and palatability in wet diets on food selection in cats. J Anim Physiol Anim Nutr (Berl). 101(2), 320-328.
78. Sirenko, S. (2019). Vyvchennya rynky і formuvannya popytu na rynku kormiv dlya domashnikh tvaryn. Ekonomika ta upravlinnya pidpryemstvamy, 32, 213-217. [in Ukrainian].
79. Zakon Ukrainu “Pro bezpechnist ta higienu kormiv”, vid 21 Grudnya 2017. Available from: https://zakon.rada.gov.ua/laws/show/2264-19. [in Ukrainian].
80. Smyrnov D. Koshky. (2016). Bolʹshaya éntsyklopedyya. [Great encyclopedia]. M.: AST, 256. [in Ukrainian].
81. Baranovskiy A.YU. (2007). Khvoroby nepravylʹnoho kharchuvannya. [Diseases of malnutrition]. SPb. [in Ukrainian].
82. Tsypriyan V.I. (1999). Hihiyena kharchuvannya z osnovamy nutrytsiolohiyi / Za red. V.I. Tsypriyana. [Food hygiene with the basics of nutrition].K., [in Ukrainian].
83. Holubev V.N. (2003). Kharchovi i biolohichno aktyvni dobavky. [Food and dietary supplements]. M., [in Ukrainian].
84. Martynchuk A.N., Maev Y.V., Yanushevych O.O. (2005). Obshchaya nutrytsyolohyya. [General nutrition]. M., [in Ukrainian].
85. Drohovoz S.M. (2007). Farmakolohyya na ladonyakh. [Pharmacology on the palms].KH., [in Ukrainian].
Published
2022-06-29
How to Cite
Shulga, A. R., & Fotin, A. V. (2022). ARTICLE REVIEW APPLICATION OF BIO ADDITIVES: NUTRICEUTICS, PARAMPHARMATICS, PROBIOTICS IN THE DIETS OF COMPANION ANIMALS. Bulletin of Sumy National Agrarian University. The Series: Veterinary Medicine, (1 (56), 58-69. https://doi.org/10.32845/bsnau.vet.2022.1.9