СТРЕПТОКОКОВА ІНФЕКЦІЯ СВИНЕЙ (ДІАГНОСТИКА, ПРОФІЛАКТИКА, ЛІКУВАННЯ)
Ключові слова:
стрептококова інфекція, свині, діагностика, профілактика, лікування.
Анотація
Streptococcus suis (S. suis) є важливим зоонозним патогеном, який може спричинити серйозні захворювання, такі як менінгіт, пневмонія, ендокардит, полісерозит, артрит, септицемія та аборт у свиней. В останні роки рівень захворюваності на стрептококовий менінгіт демонструє значну тенденцію до зростання. Для людини S. suis також є небезпечним патогеном. Тому посилення профілактики та боротьби із захворюванням є актуальним завданням. Передумовою індукції менінгіту є те, що S. suis проникає в центральну нервову систему та порушує гемато- енцефалічний бар’єр (ГЕБ). Через наявність гематоенцефалічного бар’єру, більшість бактерій з крові не може потрапити в мозок. Організм покладається на цей бар’єр, щоб захистити тканину мозку від пошкоджень і підтримувати гомеостаз центральної нервової системи. Мікросудинні ендотеліальні клітини мозку (BMEC) є основним компонентом гематоенцефалічного бар’єру, і різноманітні неврологічні захворювання пов’язані з дисфункцією гематоенцефалічного бар’єру, і S. suis може взаємодіяти з мікросудинними ендотеліальними клітинами головного мозку, а потім проникати через гематоенцефалічний бар'єр, щоб викликати інфекцію центральної нервової системи. Однак антибіотики, які використовуються для лікування інфекції, не можуть пройти через бар’єр, щоб досягти терапевтичної цільової ділянки, що є ключем до труднощів у контролі бактеріального менінгіту. Таким чином, з’ясування механізму проникнення S. suis через гематоенцефалічний бар’єр у центральну нервову систему є важливим проривом у розробці стратегії контролю менінгіту S. suis. Внаслідок тривалого невиправданого застосування антибіотиків підвищується резистентність бактерій, лікування антибіотиками порушує нормальний гомеостаз організму та кишкову флору. Проблеми, спричинені тривалим, широкомасштабним використанням антибіотиків, стають дедалі серйознішими. Менінгіт, викликаний streptococcus suis, більше не можна лікувати звичайними антибіотиками. Тому необхідно мати глибоке розу- міння патогенезу менінгіту. У цій статті розглядається дані щодо клінічних ознак і симптомів хвороби, пато- логічних змін, лабораторної діагностики, заходів профілактики та лікування стрептококової інфекції свиней за останні роки.
Посилання
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2. Arends, J., & Zanen, H. (1988). Meningitis caused by Streptococcus suis in humans. Reviews of infectious diseases, 10(1), 131-137.
3. Benga, L., Friedl, P., & Valentin-Weigand, P. (2005). Adherence of Streptococcus suis to porcine endothelial cells. Journal of Veterinary Medicine, Series B, 52(9), 392-395.
4. Benga, L., Goethe, R., Rohde, M., & Valentin-Weigand, P. (2004). Non-encapsulated strains reveal novel insights in invasion and survival of Streptococcus suis in epithelial cells. Cellular microbiology, 6(9), 867-881.
5. Brassard, J., Gottschalk, M., & Quessy, S. (2001). Decrease of the adhesion of Streptococcus suis serotype 2 mutants to embryonic bovine tracheal cells and porcine tracheal rings. Canadian Journal of Veterinary Research, 65(3), 156.
6. Chang, P., Li, W., Shi, G., Li, H., Yang, X., Xia, Z., . . . Bei, W. (2018). The VraSR regulatory system contributes to virulence in Streptococcus suis via resistance to innate immune defenses. Virulence, 9(1), 771-782.
7. Cloutier, G., D’allaire, S., Martinez, G., Surprenant, C., Lacouture, S., & Gottschalk, M. (2003). Epidemiology of Streptococcus suis serotype 5 infection in a pig herd with and without clinical disease. Veterinary microbiology, 97(1-2), 135-151.
8. Collin, M., & Ehlers, M. (2013). The carbohydrate switch between pathogenic and immunosuppressive antigenspecific antibodies. Experimental dermatology, 22(8), 511-514.
9. Dai, J., Lai, L., Tang, H., Wang, W., Wang, S., Lu, C., . . . Wu, Z. (2018). Streptococcus suis synthesizes deoxyadenosine and adenosine by 5’-nucleotidase to dampen host immune responses. Virulence, 9(1), 1509-1520.
10. de Greeff, A., Buys, H., Verhaar, R., Dijkstra, J., van Alphen, L., & Smith, H. E. (2002). Contribution of fibronectinbinding protein to pathogenesis of Streptococcus suis serotype 2. Infection and immunity, 70(3), 1319-1325.
11. Dekker, N., Bouma, A., Daemen, I., Klinkenberg, D., van Leengoed, L., Wagenaar, J. A., & Stegeman, A. (2013). Effect of spatial separation of pigs on spread of Streptococcus suis serotype 9. PLoS One, 8(4), e61339.
12. Deng, S., Xu, T., Fang, Q., Yu, L., Zhu, J., Chen, L., . . . Zhou, R. (2018). The surface-exposed protein SntA contributes to complement evasion in zoonotic Streptococcus suis. Frontiers in Immunology, 9, 1063.
13. Done, S., Williamson, S. M., & Strugnell, B. W. (2012). Nervous and locomotor systems. Diseases of swine, 10, 303-305.
14. Feng, Y., Zhang, H., Wu, Z., Wang, S., Cao, M., Hu, D., & Wang, C. (2014). Streptococcus suis infection: an emerging/reemerging challenge of bacterial infectious diseases? Virulence, 5(4), 477-497.
15. Gelberg, H. B. (2017). Alimentary system and the peritoneum, omentum, mesentery, and peritoneal cavity. Pathologic basis of veterinary disease, 324.
16. Gottschalk, M., & Segura, M. (2000). The pathogenesis of the meningitis caused by Streptococcus suis: the unresolved questions. Veterinary microbiology, 76(3), 259-272.
17. Gottschalk, M., Segura, M., & Xu, J. (2007). Streptococcus suis infections in humans: the Chinese experience and the situation in North America. Animal health research reviews, 8(1), 29-45.
18. Guo, G., Du, D., Yu, Y., Zhang, Y., Qian, Y., & Zhang, W. (2021). Pan-genome analysis of Streptococcus suis serotype 2 revealed genomic diversity among strains of different virulence. Transboundary and Emerging Diseases, 68(2), 637-647.
19. Haataja, S., Tikkanen, K., Hytönen, J., & Finne, J. (1996). The Galα1–4Gal-binding adhesin of Streptococcus suis, a Gram-positive meningitis-associated bacterium. Toward Anti-Adhesion Therapy for Microbial Diseases, 25-34.
20. Hedegaard, S. S., Zaccarin, M., & Lindberg, J. (2013). Septic arthritis caused by Streptococcus suis. Ugeskrift for Laeger, 175(22), 1574-1575.
21. Hlebowicz, M., Jakubowski, P., & Smiatacz, T. (2019). Streptococcus suis meningitis: epidemiology, clinical presentation and treatment. Vector-Borne and Zoonotic Diseases, 19(8), 557-562.
22. Hughes, J. M., Wilson, M. E., Wertheim, H. F., Nghia, H. D. T., Taylor, W., & Schultsz, C. (2009). Streptococcus suis: an emerging human pathogen. Clinical infectious diseases, 48(5), 617-625.
23. Jiang, X., Yang, Y., Zhou, J., Zhu, L., Gu, Y., Zhang, X., . . . Fang, W. (2016). Roles of the putative type IV-like secretion system key component VirD4 and PrsA in pathogenesis of Streptococcus suis type 2. Frontiers in cellular and infection microbiology, 6, 172.
24. LeBel, G., Vaillancourt, K., Yi, L., Gottschalk, M., & Grenier, D. (2018). Dipeptidylpeptidase IV of Streptococcus suis degrades the porcine antimicrobial peptide PR-39 and neutralizes its biological properties. Microbial pathogenesis, 122, 200-206.
25. Li, Q., Fu, Y., Ma, C., He, Y., Yu, Y., Du, D., . . . Zhang, W. (2017). The non-conserved region of MRP is involved in the virulence of Streptococcus suis serotype 2. Virulence, 8(7), 1274-1289.
26. Li, Q., Ma, C., Fu, Y., He, Y., Yu, Y., Du, D., . . . Zhang, W. (2017). Factor H specifically capture novel Factor H-binding proteins of Streptococcus suis and contribute to the virulence of the bacteria. Microbiological research, 196, 17-25.
27. Li, T., & Yu, X. (2019). Isolation and identification of Streptococcus suis. Swine Production(3), 116-118.
28. Lin, X., Huang, C., Shi, J., Wang, R., Sun, X., Liu, X., . . . Jin, M. (2015). Investigation of pathogenesis of H1N1 influenza virus and swine Streptococcus suis serotype 2 co-infection in pigs by microarray analysis. PLoS One, 10(4), e0124086.
29. Liu, M., Xia, X., Liu, X., & Kasianenko, O. (2021). Research Progress on the pathogenic mechanism of Streptococcus suis 2. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 23(104), 30-35.
30. Liu, W., Tan, M., Zhang, C., Xu, Z., Li, L., & Zhou, R. (2018). Functional characterization of murB-potABCD operon for polyamine uptake and peptidoglycan synthesis in Streptococcus suis. Microbiological research, 207, 177-187.
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Опубліковано
2023-11-21
Як цитувати
Касяненко, О. І., & Люй, М. (2023). СТРЕПТОКОКОВА ІНФЕКЦІЯ СВИНЕЙ (ДІАГНОСТИКА, ПРОФІЛАКТИКА, ЛІКУВАННЯ). Вісник Сумського національного аграрного університету. Серія: Ветеринарна медицина, (3(62), 125-130. https://doi.org/10.32782/bsnau.vet.2023.3.18
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