СТАН МЕТАБОЛІЧНИХ ПОКАЗНИКІВ КРОВІ БІЛИХ ЩУРІВ ЗА СУБХРОНІЧНОГО ПЕРОРАЛЬНОГО НАДХОДЖЕННЯ НАНОЧАСТИНОК ОРТОВАНАДАТУ ЛАНТАНУ НА ФОНІ КОРМОВОГО СТРЕСУ
Ключові слова:
наночастинки ортованадату лантану; кормовий стрес; амінотрансферази; пероксидне окиснення ліпідів; білі щури; цитотоксичність; адаптогенна дія
Анотація
Виходячи із доведених протекторних властивостей наночастинок ортованадату лантану, активованого Європієм (NP LaVO4:Eu3+), можливим напрямом їх застосування є використання у якості кормової добавки, оскільки неорганічні (оксиди, хлориди, нітрати) та органічні (цитрати, кормові дріжджі, збагачені Лантаном) форми Лантану вже застосовуються у світовому тваринництві, позитивно впливаючи на ростові якості свиней і курчат-бройлерів, яєчну продуктивність курей-несучок, покращують добовий приріст і виробництво молока великої рогатої худоби, перетравність поживних речовин раціону овець. Проте ефективність кормової добавки має на увазі тривале введення до організму тварин та повинна підтверджуватися покращенням стану організму в умовах стресового фактора. Тому метою даної роботи було дослідження стану метаболічних показників крові щурів за субхронічного перорального надходження наночастинок ортованадату лантану на фоні кормового стресу. У роботі використовували дослідні зразки NP LaVO4:Eu3+ (стрижнеподібна геометрія; розмір 8×80 нм; вихідна концентрація 1,0 г/дм3). Експериментальні дослідження на щурах були проведені на базі віварію ННЦ «ІЕКВМ». У якості об’єкта досліджень було використано 140 статевозрілих щурів-самців лінії Вістар з початковою масою (220–230) г. За принципом аналогів було сформовано 4 групи тварин по 35 щурів у кожній. Упродовж експерименту тварини контрольної групи отримували питну воду без добавок; щурам І дослідної групи випоювали розчин NP LaVO4:Eu3+ у дозі 0,2 мг/дм3 (≈ 0,03 мг/кг маси тіла); ІІ дослідної групи – у дозі 1,0 мг/дм3 (≈ 0,15 мг/кг маси тіла) і щурам ІІІ дослідної групи – у дозі 2,0 мг/дм3 (≈ 0,30 мг/кг маси тіла). Випоювання здійснювали протягом 56 діб, потім його завершували і спостерігали за щурами ще 14 діб. Як стресовий фактор використовували незбалансований за поживними речовинами раціон. В результаті виконання роботи установлено, що за умов кормового стресу NP LaVO4:Eu3+ у дозах 0,2 і 1,0 мг/дм3 питної води (≈ 0,03 і ≈0,15 мг/кг маси тіла) проявляють адаптогенну дію на організм білих щурів із оптимальним терміном застосування – 56 і 28 діб відповідно. Проте, тривале пероральне введення NP LaVO4:Eu3+ у дозі 2,0 мг/дм3 питної води (≈ 0,30 мг/кг маси тіла) в організмі щурів спричинює гепато(цито-)токсичну дію, що має незворотній характер. Перспективою подальших досліджень у цьому напрямку є визначення розподілу Лантану в організмі білих щурів за умов кормового стресу.
Посилання
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Опубліковано
2023-06-06
Як цитувати
Маслюк, А. В., Оробченко, О. Л., Романько, М. Є., Клочков, В. К., Єфімова, С. Л., Кавок, Н. С., & Курбацька, О. В. (2023). СТАН МЕТАБОЛІЧНИХ ПОКАЗНИКІВ КРОВІ БІЛИХ ЩУРІВ ЗА СУБХРОНІЧНОГО ПЕРОРАЛЬНОГО НАДХОДЖЕННЯ НАНОЧАСТИНОК ОРТОВАНАДАТУ ЛАНТАНУ НА ФОНІ КОРМОВОГО СТРЕСУ. Вісник Сумського національного аграрного університету. Серія: Ветеринарна медицина, (1(60), 63-73. https://doi.org/10.32782/bsnau.vet.2023.1.11
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